Protein: PUR1
Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT)

Gene: PUR1, PPAT
Organism: Homo sapiens
Interactions: 54
UniProt ID: Q06203

Gene Ontology (top 5):
GO:0004044 - amidophosphoribosyltransferase activity
GO:0005829 - cytosol
GO:0006164 - purine nucleotide biosynthetic process
GO:0006177 - GMP biosynthetic process
GO:0006189 - 'de novo' IMP biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

963502

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

3

2

High-throughput

0.662

High

1054242

NUDT5
ADP-sugar pyrophosphatase

3

0

High-throughput

0.634

High

1054231

MMS19
MMS19 nucleotide excision repair protein homolog

3

1

Small-scale

0.633

High

241476

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

1054219

CUL3
Cullin-3

2

5

High-throughput

0.584

High

1054237

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

2

High-throughput

0.584

High

1054244

CIA2B
Cytosolic iron-sulfur assembly component 2B

2

0

Small-scale

0.547

High

927251

ATX1
Ataxin-1

1

3

High-throughput

0.541

High

1054234

EPT1
Ethanolaminephosphotransferase 1

1

0

High-throughput

0.518

High

185628

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

188251

HDAC3
Histone deacetylase 3

1

3

High-throughput

0.479

High

315494

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

345703

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

830608

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

970381

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

1054224

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1054230

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1054232

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1054236

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1054240

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1054241

FBW1B
F-box/WD repeat-containing protein 11

1

4

High-throughput

0.479

High

542765

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

High-throughput

0.458

High

142328

PEX7
Peroxisomal targeting signal 2 receptor

1

3

High-throughput

0.445

High

258847

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.445

High

1054221

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

1054227

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.445

High

1054243

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.445

High

293601

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

302814

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

4

High-throughput

0.437

High

411788

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

588529

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

695278

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

766477

PHB1
Prohibitin 1

1

2

High-throughput

0.437

High

768019

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1054223

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1054226

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

1054235

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

1054217

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.426

High

409360

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.407

High

1054229

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

3

High-throughput

0.407

High

1054233

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.407

High

886787

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.373

High

124316

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

604645

UBF1
Nucleolar transcription factor 1

1

0

High-throughput

0.249

Low

1017769

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.249

Low

1054220

CRY1
Cryptochrome-1

1

0

High-throughput

0.249

Low

1054222

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

1054225

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

330135

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

1054218

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1054228

F167A
Protein FAM167A

1

0

High-throughput

0.232

Low

1054238

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.232

Low

1054239

CAH10
Carbonic anhydrase-related protein 10

1

0

High-throughput

0.232

Low

1054245

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025