Protein: NSMA
Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Lyso-platelet-activating factor-phospholipase C) (Lyso-PAF-PLC) (Neutral sphingomyelinase) (N-SMase) (nSMase) (nSMase1)

Gene: NSMA, SMPD2
Organism: Homo sapiens
Interactions: 85
UniProt ID: O60906

Gene Ontology (top 5):
GO:0004767 - sphingomyelin phosphodiesterase activity
GO:0005783 - endoplasmic reticulum
GO:0005886 - plasma membrane
GO:0005901 - caveola
GO:0006684 - sphingomyelin metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

245491

CLM6
CMRF35-like molecule 6

1

0

High-throughput

0.656

High

245473

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

3

0

High-throughput

0.638

High

245513

PLVAP
Plasmalemma vesicle-associated protein

3

0

High-throughput

0.638

High

245524

CC50A
Cell cycle control protein 50A

3

0

High-throughput

0.638

High

245501

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

1

High-throughput

0.628

High

245506

TMED6
Transmembrane emp24 domain-containing protein 6

2

3

High-throughput

0.628

High

245520

PCDBG
Protocadherin beta-16

2

8

High-throughput

0.628

High

245532

PCDGG
Protocadherin gamma-B4

2

8

High-throughput

0.628

High

245536

PCDB7
Protocadherin beta-7

2

8

High-throughput

0.628

High

245539

PCDG5
Protocadherin gamma-A5

2

8

High-throughput

0.628

High

245540

PCDA3
Protocadherin alpha-3

2

6

High-throughput

0.628

High

245542

PCDC2
Protocadherin alpha-C2

2

7

High-throughput

0.628

High

245489

KCNC4
Potassium voltage-gated channel subfamily C member 4

2

0

High-throughput

0.602

High

245494

LRC32
Transforming growth factor beta activator LRRC32

2

0

High-throughput

0.602

High

245507

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

0

High-throughput

0.602

High

170755

PGRC2
Membrane-associated progesterone receptor component 2

2

0

High-throughput

0.580

High

245490

DCE2
Glutamate decarboxylase 2

2

0

High-throughput

0.580

High

245495

NTCP
Hepatic sodium/bile acid cotransporter

2

0

High-throughput

0.580

High

245527

LAT2
Large neutral amino acids transporter small subunit 2

2

0

High-throughput

0.580

High

245530

NDRG4
Protein NDRG4

2

0

High-throughput

0.580

High

245469

RTN3
Reticulon-3

1

1

High-throughput

0.536

High

245470

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

3

High-throughput

0.536

High

245472

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

3

High-throughput

0.536

High

245474

EDNRA
Endothelin-1 receptor

1

1

High-throughput

0.536

High

245476

CD1B
T-cell surface glycoprotein CD1b

1

1

High-throughput

0.536

High

245493

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

1

High-throughput

0.536

High

245496

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.536

High

245517

RXFP1
Relaxin receptor 1

1

1

High-throughput

0.536

High

245519

RTN4
Reticulon-4

1

1

High-throughput

0.536

High

245534

TMED5
Transmembrane emp24 domain-containing protein 5

1

3

High-throughput

0.536

High

245535

TMED7
Transmembrane emp24 domain-containing protein 7

1

2

High-throughput

0.536

High

245537

PCDGL
Protocadherin gamma-C4

1

7

High-throughput

0.536

High

245538

PCDGE
Protocadherin gamma-B2

1

8

High-throughput

0.536

High

245541

PCDAB
Protocadherin alpha-11

1

7

High-throughput

0.536

High

173255

S22A2
Solute carrier family 22 member 2

1

0

High-throughput

0.513

High

199990

GPAA1
Glycosylphosphatidylinositol anchor attachment 1 protein

1

0

High-throughput

0.513

High

234001

O10H2
Olfactory receptor 10H2

1

0

High-throughput

0.513

High

245477

GRK4
G protein-coupled receptor kinase 4

1

0

High-throughput

0.513

High

245478

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

0

High-throughput

0.513

High

245484

JAK3
Tyrosine-protein kinase JAK3

1

0

High-throughput

0.513

High

245488

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.513

High

245492

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

0

High-throughput

0.513

High

245497

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.513

High

245498

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

245500

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

0

High-throughput

0.513

High

245503

I22R1
Interleukin-22 receptor subunit alpha-1

1

0

High-throughput

0.513

High

245509

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.513

High

245512

CIB1
Calcium and integrin-binding protein 1

1

0

High-throughput

0.513

High

245514

NMUR2
Neuromedin-U receptor 2

1

0

High-throughput

0.513

High

245515

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

245518

KCMB3
Calcium-activated potassium channel subunit beta-3

1

0

High-throughput

0.513

High

245544

STK24
Serine/threonine-protein kinase 24

1

0

High-throughput

0.513

High

245528

LAMP5
Lysosome-associated membrane glycoprotein 5

1

0

High-throughput

0.493

High

245475

DMB
HLA class II histocompatibility antigen, DM beta chain

1

3

High-throughput

0.489

High

245510

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.489

High

245471

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

3

High-throughput

0.479

High

245508

Q96AL5
PBX3 protein

1

1

High-throughput

0.470

High

245504

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

245479

PBX3
Pre-B-cell leukemia transcription factor 3

1

1

High-throughput

0.439

High

245481

FNTB
Protein farnesyltransferase subunit beta

3

0

High-throughput

0.347

High

245480

MTHR
Methylenetetrahydrofolate reductase

3

0

High-throughput

0.345

High

180583

TEX28
Testis-specific protein TEX28

2

0

High-throughput

0.328

High

245531

APC10
Anaphase-promoting complex subunit 10

2

0

High-throughput

0.318

High

134565

CCN1
CCN family member 1

2

0

High-throughput

0.316

High

245483

STAR
Steroidogenic acute regulatory protein, mitochondrial

2

0

High-throughput

0.316

High

245485

ARFP1
Arfaptin-1

2

0

High-throughput

0.316

High

245505

COQ8A
Atypical kinase COQ8A, mitochondrial

2

0

High-throughput

0.316

High

245521

KISHB
Protein kish-B

2

0

High-throughput

0.316

High

245522

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

245529

PITC1
Cytoplasmic phosphatidylinositol transfer protein 1

2

0

High-throughput

0.316

High

127619

EF2K
Eukaryotic elongation factor 2 kinase

1

0

High-throughput

0.279

Low

157265

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.279

Low

245482

SYHM
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

245486

EREP3
Protein ENTREP3

1

0

High-throughput

0.279

Low

245487

CDK6
Cyclin-dependent kinase 6

1

0

High-throughput

0.279

Low

245502

CDKL3
Cyclin-dependent kinase-like 3

1

0

High-throughput

0.279

Low

245511

PIGS
GPI transamidase component PIG-S

1

0

High-throughput

0.279

Low

245516

MANS1
MANSC domain-containing protein 1

1

0

High-throughput

0.279

Low

245525

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.279

Low

245526

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

0

High-throughput

0.279

Low

245545

CDY2
Testis-specific chromodomain protein Y 2

1

0

High-throughput

0.279

Low

245533

SHLB1
Endophilin-B1

1

0

High-throughput

0.268

Low

245499

TMM31
Transmembrane protein 31

1

0

High-throughput

0.251

Low

245523

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

245543

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024