Protein: TBC15
TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP)

Gene: TBC15, TBC1D15
Organism: Homo sapiens
Interactions: 149
UniProt ID: Q8TC07

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005576 - extracellular region
GO:0005737 - cytoplasm
GO:0043087 - regulation of GTPase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1253215

TBC17
TBC1 domain family member 17

2

7

High-throughput

0.811

High

1253196

OPTN
Optineurin

6

5

High-throughput

0.737

High

199935

SPIT2
Kunitz-type protease inhibitor 2

3

6

High-throughput

0.667

High

848908

AL3A2
Aldehyde dehydrogenase family 3 member A2

3

1

High-throughput

0.667

High

1253197

CEP63
Centrosomal protein of 63 kDa

5

3

High-throughput

0.658

High

840768

DYN2
Dynamin-2

2

3

High-throughput

0.628

High

983395

DYN1
Dynamin-1

2

3

High-throughput

0.628

High

1253187

UTP15
U3 small nucleolar RNA-associated protein 15 homolog

2

1

High-throughput

0.628

High

1201850

TAXB1
Tax1-binding protein 1

4

6

Small-scale

0.625

High

592392

RAB5A
Ras-related protein Rab-5A

1

20

Small-scale

0.621

High

673501

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.618

High

1240025

UBAC2
Ubiquitin-associated domain-containing protein 2

3

1

High-throughput

0.616

High

1253228

FIS1
Mitochondrial fission 1 protein

3

2

Small-scale

0.615

High

116698

UBXN8
UBX domain-containing protein 8

3

2

High-throughput

0.609

High

851217

CCNH
Cyclin-H

3

2

High-throughput

0.609

High

1052446

FLOT2
Flotillin-2

3

2

High-throughput

0.609

High

1172839

CC121
Coiled-coil domain-containing protein 121

3

1

High-throughput

0.609

High

1205349

STX12
Syntaxin-12

3

6

High-throughput

0.609

High

584434

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

0

High-throughput

0.602

High

823612

CAMLG
Guided entry of tail-anchored proteins factor CAMLG

2

0

High-throughput

0.602

High

1253223

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

0

High-throughput

0.602

High

476088

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

3

High-throughput

0.594

High

1014796

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

2

0

High-throughput

0.585

High

228131

PRKN
E3 ubiquitin-protein ligase parkin

2

9

Small-scale

0.584

High

1059547

KIF22
Kinesin-like protein KIF22

2

2

High-throughput

0.574

High

1253217

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

1

High-throughput

0.574

High

182185

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

3

High-throughput

0.571

High

1253204

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

2

20

High-throughput

0.555

High

844641

RAB5C
Ras-related protein Rab-5C

1

20

Small-scale

0.555

High

895369

RAB5B
Ras-related protein Rab-5B

1

20

Small-scale

0.555

High

845097

RAB7A
Ras-related protein Rab-7a

1

20

High-throughput

0.553

High

884545

RAB25
Ras-related protein Rab-25

1

19

High-throughput

0.553

High

70695

MYO9A
Unconventional myosin-IXa

1

1

High-throughput

0.536

High

328360

S1PR4
Sphingosine 1-phosphate receptor 4

1

3

High-throughput

0.536

High

529455

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

598756

S1PR1
Sphingosine 1-phosphate receptor 1

1

3

High-throughput

0.536

High

908039

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

1218845

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1253193

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1253211

CLC4M
C-type lectin domain family 4 member M

1

3

High-throughput

0.536

High

1253216

LPAR2
Lysophosphatidic acid receptor 2

1

3

High-throughput

0.536

High

1253225

DYN3
Dynamin-3

1

3

High-throughput

0.536

High

1253227

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

1

High-throughput

0.536

High

306240

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.535

High

891232

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.527

High

1253222

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

5

High-throughput

0.523

High

894778

RAB8A
Ras-related protein Rab-8A

1

19

Small-scale

0.514

High

351176

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.513

High

1128346

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.513

High

1240616

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.513

High

1253188

THEM6
Protein THEM6

1

0

High-throughput

0.513

High

1253200

ABHEA
Protein ABHD14A

1

0

High-throughput

0.513

High

1253203

BRNP2
BMP/retinoic acid-inducible neural-specific protein 2

1

0

High-throughput

0.513

High

1253226

PSG8
Pregnancy-specific beta-1-glycoprotein 8

1

0

High-throughput

0.513

High

169548

BET1
BET1 homolog

1

3

High-throughput

0.489

High

198119

MTLR
Motilin receptor

1

3

High-throughput

0.489

High

454732

TACD2
Tumor-associated calcium signal transducer 2

1

5

High-throughput

0.489

High

600802

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

5

High-throughput

0.489

High

686335

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

7

High-throughput

0.489

High

783689

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

6

High-throughput

0.489

High

814282

GLR
Glucagon receptor

1

9

High-throughput

0.489

High

876163

PAR2
Proteinase-activated receptor 2

1

13

High-throughput

0.489

High

1031024

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

12

High-throughput

0.489

High

1041408

CUL2
Cullin-2

1

5

High-throughput

0.489

High

1067544

P2RY6
P2Y purinoceptor 6

1

13

High-throughput

0.489

High

1079548

NEDD8
NEDD8

1

1

High-throughput

0.489

High

1166519

BTNL9
Butyrophilin-like protein 9

1

6

High-throughput

0.489

High

1174562

CYS1
Cystin-1

1

1

High-throughput

0.489

High

1202510

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

3

High-throughput

0.489

High

1238145

LRTM2
Leucine-rich repeat and transmembrane domain-containing protein 2

1

4

High-throughput

0.489

High

1253210

UN93B
Protein unc-93 homolog B1

1

2

High-throughput

0.489

High

1253229

GPR45
Probable G-protein coupled receptor 45

1

4

High-throughput

0.489

High

1253208

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.481

High

119450

LEG9
Galectin-9

1

2

High-throughput

0.479

High

163033

XPO1
Exportin-1

1

5

High-throughput

0.479

High

260584

TP4A3
Protein tyrosine phosphatase type IVA 3

1

2

High-throughput

0.479

High

569892

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

573813

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

779779

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

808790

YAP1
Transcriptional coactivator YAP1

1

6

High-throughput

0.479

High

941207

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

946049

DLK1
Protein delta homolog 1

1

2

High-throughput

0.479

High

1036749

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

1038557

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.479

High

1042100

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1167722

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

1

High-throughput

0.479

High

1170928

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1204792

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.479

High

1253189

DNJC9
DnaJ homolog subfamily C member 9

1

2

High-throughput

0.479

High

1253205

WWTR1
WW domain-containing transcription regulator protein 1

1

6

High-throughput

0.479

High

1253207

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

1253209

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

1253212

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1253213

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1253221

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

322906

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

660863

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

0

High-throughput

0.458

High

961204

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1081334

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1239697

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1253192

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

1253202

MLP3C
Microtubule-associated proteins 1A/1B light chain 3C

1

20

High-throughput

0.457

High

100986

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

232357

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.437

High

385206

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.437

High

553248

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

651750

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

684904

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.437

High

720973

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

793133

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

1

High-throughput

0.437

High

813620

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.437

High

887196

DJB13
DnaJ homolog subfamily B member 13

1

4

High-throughput

0.437

High

908855

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.437

High

1026483

RFA4
Replication protein A 30 kDa subunit

1

5

High-throughput

0.437

High

1056087

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.437

High

1066432

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.437

High

1074950

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.437

High

1088212

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

5

High-throughput

0.437

High

1165780

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1188592

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1205997

MIB1
E3 ubiquitin-protein ligase MIB1

1

1

High-throughput

0.437

High

1253186

DCA11
DDB1- and CUL4-associated factor 11

1

2

High-throughput

0.437

High

1253190

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.437

High

1253194

PF21A
PHD finger protein 21A

1

2

High-throughput

0.437

High

581799

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.407

High

1241537

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

1079761

EREP1
Endosomal transmembrane epsin interactor 1

3

0

High-throughput

0.347

High

658267

5HT2C
5-hydroxytryptamine receptor 2C

2

0

High-throughput

0.328

High

1152430

GRAM4
GRAM domain-containing protein 4

2

0

High-throughput

0.328

High

1162901

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

2

0

High-throughput

0.328

High

1253199

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

2

0

High-throughput

0.328

High

1253214

PACC1
Proton-activated chloride channel

2

0

High-throughput

0.328

High

1233308

PNKD
Probable hydrolase PNKD

2

0

High-throughput

0.318

High

313114

GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.279

Low

957438

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.279

Low

1059488

FXYD3
FXYD domain-containing ion transport regulator 3

1

0

High-throughput

0.279

Low

1189762

TMC4
Transmembrane channel-like protein 4

1

0

High-throughput

0.279

Low

1253195

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.279

Low

1253198

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

1253201

TMED9
Transmembrane emp24 domain-containing protein 9

1

0

High-throughput

0.279

Low

1253206

T126A
Transmembrane protein 126A

1

0

High-throughput

0.279

Low

1253219

PLS4
Phospholipid scramblase 4

1

0

High-throughput

0.279

Low

1101182

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1184223

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

1253191

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.249

Low

1253220

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1253224

RCOR1
REST corepressor 1

1

0

High-throughput

0.249

Low

1253218

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

1087

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024