Protein: SCO2
Protein SCO2 homolog, mitochondrial

Gene: SCO2
Organism: Homo sapiens
Interactions: 119
UniProt ID: O43819

Gene Ontology (top 5):
GO:0001654 - eye development
GO:0001701 - in utero embryonic development
GO:0003012 - muscle system process
GO:0005507 - copper ion binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

228778

AIFM1
Apoptosis-inducing factor 1, mitochondrial

3

1

High-throughput

0.643

High

228773

SCO1
Protein SCO1 homolog, mitochondrial

1

4

High-throughput

0.618

High

228869

CIDEB
Lipid transferase CIDEB

2

1

High-throughput

0.553

High

228775

EYA4
Protein phosphatase EYA4

2

3

High-throughput

0.533

High

217562

TGON2
Trans-Golgi network integral membrane protein 2

2

1

High-throughput

0.521

High

228826

CE162
Centrosomal protein of 162 kDa

2

1

High-throughput

0.521

High

228774

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

High-throughput

0.513

High

228835

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

228819

COX17
Cytochrome c oxidase copper chaperone

1

1

Small-scale

0.501

High

228785

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.500

High

165680

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

1

High-throughput

0.489

High

228770

KS6A5
Ribosomal protein S6 kinase alpha-5

1

1

High-throughput

0.489

High

228782

FA12
Coagulation factor XII

1

2

High-throughput

0.489

High

228793

MET
Hepatocyte growth factor receptor

1

3

High-throughput

0.489

High

228795

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

2

High-throughput

0.489

High

228830

PKN3
Serine/threonine-protein kinase N3

1

2

High-throughput

0.489

High

228851

STK33
Serine/threonine-protein kinase 33

1

1

High-throughput

0.489

High

228787

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

124559

EYA2
Protein phosphatase EYA2

1

3

High-throughput

0.479

High

137571

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.479

High

228771

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

2

High-throughput

0.479

High

228780

COX2
Cytochrome c oxidase subunit 2

1

2

Small-scale

0.479

High

228794

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

1

High-throughput

0.479

High

228802

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

228823

COA6
Cytochrome c oxidase assembly factor 6 homolog

1

1

Small-scale

0.479

High

228847

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

228854

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

4

High-throughput

0.479

High

228855

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

228858

OPA3
Optic atrophy 3 protein

1

1

High-throughput

0.479

High

228860

SFXN1
Sideroflexin-1

1

1

High-throughput

0.479

High

228769

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

228786

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

228842

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

228852

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

228863

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

228865

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

228879

STYL1
Serine/threonine/tyrosine-interacting-like protein 1

1

0

High-throughput

0.458

High

228781

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.457

High

228784

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

4

High-throughput

0.457

High

228789

INSR
Insulin receptor

1

6

High-throughput

0.457

High

228791

IGF1R
Insulin-like growth factor 1 receptor

1

5

High-throughput

0.457

High

228810

EPHA5
Ephrin type-A receptor 5

1

2

High-throughput

0.457

High

228821

NTRK3
NT-3 growth factor receptor

1

4

High-throughput

0.457

High

228800

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

169836

AURKA
Aurora kinase A

1

1

High-throughput

0.437

High

228768

DNJB6
DnaJ homolog subfamily B member 6

1

3

High-throughput

0.437

High

228776

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.437

High

228777

HERC2
E3 ubiquitin-protein ligase HERC2

1

1

High-throughput

0.437

High

228790

CATL1
Procathepsin L

1

1

High-throughput

0.437

High

228796

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

228798

TAF1
Transcription initiation factor TFIID subunit 1

1

6

High-throughput

0.437

High

228804

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

228813

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

228814

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.437

High

228817

MTM1
Myotubularin

1

4

High-throughput

0.437

High

228824

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

1

Small-scale

0.437

High

228831

ANR11
Ankyrin repeat domain-containing protein 11

1

4

High-throughput

0.437

High

228836

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

228840

DNJB8
DnaJ homolog subfamily B member 8

1

4

High-throughput

0.437

High

228843

OPTN
Optineurin

1

1

High-throughput

0.437

High

228844

GCP3
Gamma-tubulin complex component 3

1

1

High-throughput

0.437

High

228849

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

2

High-throughput

0.437

High

228850

GCP2
Gamma-tubulin complex component 2

1

1

High-throughput

0.437

High

228853

MTMRC
Myotubularin-related protein 12

1

4

High-throughput

0.437

High

228856

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.437

High

228862

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

2

Small-scale

0.437

High

228864

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.437

High

228866

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.437

High

228867

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

4

High-throughput

0.437

High

228868

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

228871

BRPF3
Bromodomain and PHD finger-containing protein 3

1

2

High-throughput

0.437

High

228873

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.437

High

853

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

228825

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

104072

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

228812

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.407

High

228874

ST38L
Serine/threonine-protein kinase 38-like

1

2

High-throughput

0.407

High

228829

ARMC6
Armadillo repeat-containing protein 6

2

0

High-throughput

0.328

High

228818

CUL3
Cullin-3

2

0

High-throughput

0.318

High

228838

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

2

0

High-throughput

0.305

High

228834

TBA1A
Tubulin alpha-1A chain

2

0

High-throughput

0.298

High

228783

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.279

Low

228797

TSHR
Thyrotropin receptor

1

0

High-throughput

0.279

Low

228799

GPDA
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

1

0

High-throughput

0.279

Low

228805

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.279

Low

228807

MAGAA
Melanoma-associated antigen 10

1

0

High-throughput

0.279

Low

228809

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.279

Low

228816

ILK
Scaffold protein ILK

1

0

High-throughput

0.279

Low

228820

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.279

Low

228837

DCLK2
Serine/threonine-protein kinase DCLK2

1

0

High-throughput

0.279

Low

228845

HIPL1
HHIP-like protein 1

1

0

High-throughput

0.279

Low

228876

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

0

High-throughput

0.279

Low

228878

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.279

Low

228772

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

228779

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.249

Low

228788

JUN
Transcription factor Jun

1

0

High-throughput

0.249

Low

228801

SP100
Nuclear autoantigen Sp-100

1

0

High-throughput

0.249

Low

228803

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.249

Low

228806

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

228808

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

Small-scale

0.249

Low

228811

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

228822

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

0

High-throughput

0.249

Low

228827

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

228828

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low

228832

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

228833

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

228841

NEDD1
Protein NEDD1

1

0

High-throughput

0.249

Low

228846

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

228848

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

228857

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

228859

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

228861

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

228870

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

Small-scale

0.249

Low

228872

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

Small-scale

0.249

Low

228875

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

0

High-throughput

0.249

Low

228792

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.232

Low

228815

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.232

Low

228839

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

228877

PCDGH
Protocadherin gamma-B5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025