Protein: KAD2
Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed]

Gene: KAD2, AK2
Organism: Homo sapiens
Interactions: 131
UniProt ID: P54819

Gene Ontology (top 5):
GO:0004017 - AMP kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005758 - mitochondrial intermembrane space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

348437

AIFM1
Apoptosis-inducing factor 1, mitochondrial

5

5

High-throughput

0.714

High

932455

KAD2
Adenylate kinase 2, mitochondrial

1

6

High-throughput

0.618

High

932464

CUL3
Cullin-3

2

1

High-throughput

0.611

High

932474

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

3

High-throughput

0.571

High

932515

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

161972

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

5

High-throughput

0.536

High

166637

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

4

High-throughput

0.536

High

287673

KS6A5
Ribosomal protein S6 kinase alpha-5

1

3

High-throughput

0.536

High

470943

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

5

High-throughput

0.536

High

484453

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

549108

CDK4
Cyclin-dependent kinase 4

1

1

High-throughput

0.536

High

932461

S25A3
Solute carrier family 25 member 3

1

2

High-throughput

0.536

High

932466

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

2

High-throughput

0.536

High

932470

PDK4
[Pyruvate dehydrogenase

1

4

High-throughput

0.536

High

932477

SCYL2
SCY1-like protein 2

1

1

High-throughput

0.536

High

932490

STK35
Serine/threonine-protein kinase 35

1

4

High-throughput

0.536

High

932491

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.536

High

932499

AURKB
Aurora kinase B

1

3

High-throughput

0.536

High

932503

TSSK3
Testis-specific serine/threonine-protein kinase 3

1

3

High-throughput

0.536

High

932508

TSSK1
Testis-specific serine/threonine-protein kinase 1

1

4

High-throughput

0.536

High

932518

LATS2
Serine/threonine-protein kinase LATS2

1

2

High-throughput

0.536

High

932519

NRBP2
Nuclear receptor-binding protein 2

1

3

High-throughput

0.536

High

529419

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.515

High

593738

PECA1
Platelet endothelial cell adhesion molecule

1

1

High-throughput

0.515

High

605609

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

High-throughput

0.515

High

927196

ATX1
Ataxin-1

1

1

High-throughput

0.515

High

213876

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

361179

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

905531

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

932472

PKDCC
Extracellular tyrosine-protein kinase PKDCC

1

0

High-throughput

0.513

High

932485

CDK20
Cyclin-dependent kinase 20

1

0

High-throughput

0.513

High

932494

RENT1
Regulator of nonsense transcripts 1

1

0

High-throughput

0.513

High

932521

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.513

High

340444

ADCY5
Adenylate cyclase type 5

1

0

High-throughput

0.493

High

932471

MAP9
Microtubule-associated protein 9

1

0

High-throughput

0.493

High

474576

VIME
Vimentin

1

0

High-throughput

0.493

High

788875

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.493

High

574047

HXB1
Homeobox protein Hox-B1

1

1

High-throughput

0.489

High

932526

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.489

High

190660

MRP5
ATP-binding cassette sub-family C member 5

1

1

High-throughput

0.481

High

332093

MRP6
ATP-binding cassette sub-family C member 6

1

1

High-throughput

0.481

High

932510

TRI54
Tripartite motif-containing protein 54

1

8

High-throughput

0.481

High

176954

CE290
Centrosomal protein of 290 kDa

1

2

High-throughput

0.479

High

216649

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.479

High

292103

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.479

High

400536

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

411649

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

550942

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.479

High

565840

EF2
Elongation factor 2

1

3

High-throughput

0.479

High

606497

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

658667

JAK1
Tyrosine-protein kinase JAK1

1

1

High-throughput

0.479

High

659414

CRCM
Colorectal mutant cancer protein

1

2

High-throughput

0.479

High

842699

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

4

High-throughput

0.479

High

842904

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

4

High-throughput

0.479

High

842946

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

7

High-throughput

0.479

High

891082

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.479

High

891400

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

932456

CDN2D
Cyclin-dependent kinase 4 inhibitor D

1

7

High-throughput

0.479

High

932459

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

932463

PAK2
Serine/threonine-protein kinase PAK 2

1

4

High-throughput

0.479

High

932467

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

4

High-throughput

0.479

High

932475

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.479

High

932479

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

932482

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

932495

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

932496

OPTN
Optineurin

1

1

High-throughput

0.479

High

932502

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

932504

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

932512

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

2

High-throughput

0.479

High

932517

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

932520

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

High-throughput

0.479

High

932522

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

932523

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.479

High

932525

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

407795

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.460

High

123356

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

296218

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

347600

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

485854

COX6C
Cytochrome c oxidase subunit 6C

1

0

High-throughput

0.458

High

648117

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.458

High

830414

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

932457

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

932458

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

932460

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

932465

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

932469

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.458

High

932484

MTMRD
Myotubularin-related protein 13

1

0

High-throughput

0.458

High

932486

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

932493

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

932497

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

932500

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

932505

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.458

High

932506

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.458

High

932507

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

932511

ARP6
Actin-related protein 6

1

0

High-throughput

0.458

High

932513

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

932514

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

0

High-throughput

0.458

High

932516

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

653216

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.445

High

932476

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

2

High-throughput

0.445

High

254568

EIF1B
Eukaryotic translation initiation factor 1b

1

1

High-throughput

0.437

High

353146

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

685472

U2AF2
Splicing factor U2AF 65 kDa subunit

1

3

High-throughput

0.437

High

767792

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

932468

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.437

High

932478

BCOR
BCL-6 corepressor

1

2

High-throughput

0.437

High

932489

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.437

High

619639

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

932487

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

Small-scale

0.426

High

932498

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

429583

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

932473

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.279

Low

932509

UBP26
Ubiquitin carboxyl-terminal hydrolase 26

1

0

High-throughput

0.269

Low

47312

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

890717

PSN2
Presenilin-2

1

0

High-throughput

0.268

Low

895519

SERPH
Serpin H1

1

0

High-throughput

0.268

Low

218006

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

377193

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

538915

EPB41
Protein 4.1

1

0

High-throughput

0.249

Low

588303

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695032

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

832681

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.249

Low

932462

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.249

Low

932481

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

932483

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.249

Low

932488

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

932524

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

932480

SV2A
Synaptic vesicle glycoprotein 2A

1

0

High-throughput

0.232

Low

932492

S39A7
Zinc transporter SLC39A7

1

0

High-throughput

0.232

Low

932501

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025