Protein: THOC6
THO complex subunit 6 (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58)

Gene: THOC6
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q86W42

Gene Ontology (top 5):
GO:0000346 - transcription export complex
GO:0000347 - THO complex
GO:0000445 - THO complex part of transcription export complex
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1118083

DX39B
Spliceosome RNA helicase DDX39B

4

20

Small-scale

0.899

High

1292042

THOC2
THO complex subunit 2

4

20

Small-scale

0.881

High

1292050

THOC1
THO complex subunit 1

6

3

Small-scale

0.732

High

1292063

RHG26
Rho GTPase-activating protein 26

2

12

High-throughput

0.659

High

1198589

NCBP3
Nuclear cap-binding protein subunit 3

3

2

High-throughput

0.643

High

1292051

THOC3
THO complex subunit 3

2

16

High-throughput

0.628

High

342943

HERC2
E3 ubiquitin-protein ligase HERC2

1

11

High-throughput

0.618

High

854883

RECQ1
ATP-dependent DNA helicase Q1

1

20

High-throughput

0.618

High

970726

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

10

High-throughput

0.618

High

979923

H4
Histone H4

1

11

High-throughput

0.618

High

1137378

SUZ12
Polycomb protein SUZ12

1

4

High-throughput

0.618

High

1292057

ANLN
Anillin

1

9

High-throughput

0.618

High

1117193

THOC5
THO complex subunit 5

2

2

Small-scale

0.611

High

1290068

THOC4
THO complex subunit 4

2

14

Small-scale

0.595

High

831005

CCNF
Cyclin-F

2

8

High-throughput

0.584

High

1234847

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.575

High

1292061

DDX41
Probable ATP-dependent RNA helicase DDX41

1

14

High-throughput

0.575

High

1292044

ESR2
Estrogen receptor beta

2

20

High-throughput

0.571

High

1226990

A16L1
Autophagy-related protein 16-1

1

18

High-throughput

0.553

High

1254473

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

1292055

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

478108

SNRPA
U1 small nuclear ribonucleoprotein A

1

19

High-throughput

0.536

High

574355

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

7

High-throughput

0.536

High

1065279

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

1149117

SF3A1
Splicing factor 3A subunit 1

1

10

High-throughput

0.536

High

1160192

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

19

High-throughput

0.536

High

1233196

THOC7
THO complex subunit 7

1

2

High-throughput

0.536

High

1292040

ABI1
Abl interactor 1

1

18

High-throughput

0.536

High

1292058

BCLF1
Bcl-2-associated transcription factor 1

1

11

High-throughput

0.536

High

1292062

HECD1
E3 ubiquitin-protein ligase HECTD1

2

20

High-throughput

0.533

High

225629

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.513

High

832317

ID1
DNA-binding protein inhibitor ID-1

1

0

High-throughput

0.513

High

951737

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.501

High

129231

MEN1
Menin

1

5

High-throughput

0.479

High

134789

SAP18
Histone deacetylase complex subunit SAP18

1

3

High-throughput

0.479

High

302572

RNF8
E3 ubiquitin-protein ligase RNF8

1

16

High-throughput

0.479

High

346027

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

17

High-throughput

0.479

High

372465

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

401083

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

18

High-throughput

0.479

High

406350

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

472867

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

15

High-throughput

0.479

High

487488

PARP1
Poly [ADP-ribose] polymerase 1

1

16

High-throughput

0.479

High

589071

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

695860

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

768570

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

799261

BRCA1
Breast cancer type 1 susceptibility protein

1

15

High-throughput

0.479

High

904894

MECP2
Methyl-CpG-binding protein 2

1

13

High-throughput

0.479

High

1024673

VIGLN
Vigilin

1

20

High-throughput

0.479

High

1027566

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

20

High-throughput

0.479

High

1066705

NCBP1
Nuclear cap-binding protein subunit 1

1

3

Small-scale

0.479

High

1100079

TIF1B
Transcription intermediary factor 1-beta

1

20

High-throughput

0.479

High

1141199

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

1290570

ZCH18
Zinc finger CCCH domain-containing protein 18

1

20

High-throughput

0.479

High

1292041

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.479

High

1292043

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

1292045

RBP56
TATA-binding protein-associated factor 2N

1

17

High-throughput

0.479

High

1292046

FUBP1
Far upstream element-binding protein 1

1

17

High-throughput

0.479

High

1292052

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.479

High

1292053

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

1292056

NMRL1
NmrA-like family domain-containing protein 1

1

2

High-throughput

0.479

High

1292059

WWOX
WW domain-containing oxidoreductase

1

3

High-throughput

0.479

High

1292060

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

1292064

NUDC
Nuclear migration protein nudC

1

15

High-throughput

0.479

High

1292048

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

430098

JUN
Transcription factor Jun

1

17

High-throughput

0.445

High

1203181

ODFP2
Outer dense fiber protein 2

1

14

High-throughput

0.445

High

318819

RHBT1
Rho-related BTB domain-containing protein 1

1

19

High-throughput

0.437

High

375677

RASK
GTPase KRas

1

15

High-throughput

0.437

High

1292047

OTUL
Ubiquitin thioesterase otulin

1

1

Small-scale

0.437

High

1292049

CHM4C
Charged multivesicular body protein 4c

1

9

High-throughput

0.437

High

328061

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

9

High-throughput

0.407

High

952231

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

9

High-throughput

0.407

High

1214155

LITD1
LINE-1 type transposase domain-containing protein 1

1

1

High-throughput

0.407

High

1292054

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

9

High-throughput

0.407

High


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Last updated: 11Aug2025