Protein: THOC1
THO complex subunit 1 (Nuclear matrix protein p84) (p84N5) (hTREX84)

Gene: THOC1
Organism: Homo sapiens
Interactions: 218
UniProt ID: Q96FV9

Gene Ontology (top 5):
GO:0000346 - transcription export complex
GO:0000347 - THO complex
GO:0000445 - THO complex part of transcription export complex
GO:0003677 - DNA binding
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1117203

THOC5
THO complex subunit 5

10

1

Small-scale

0.975

High

1340995

THOC2
THO complex subunit 2

11

3

Small-scale

0.975

High

1233205

THOC7
THO complex subunit 7

7

1

Small-scale

0.962

High

1390955

THOC1
THO complex subunit 1

2

0

Small-scale

0.765

High

1118123

DX39B
Spliceosome RNA helicase DDX39B

11

3

Small-scale

0.756

High

1290107

THOC4
THO complex subunit 4

6

2

Small-scale

0.732

High

1292050

THOC6
THO complex subunit 6

6

3

Small-scale

0.732

High

1390956

THOC3
THO complex subunit 3

5

2

Small-scale

0.718

High

1013169

SARNP
SAP domain-containing ribonucleoprotein

3

1

High-throughput

0.675

High

1385131

MOAP1
Modulator of apoptosis 1

4

0

High-throughput

0.668

High

123162

DX39A
ATP-dependent RNA helicase DDX39A

3

3

Small-scale

0.662

High

1198630

NCBP3
Nuclear cap-binding protein subunit 3

4

0

Small-scale

0.644

High

1389758

RBM33
RNA-binding protein 33

3

0

High-throughput

0.638

High

914710

RM12
Large ribosomal subunit protein bL12m

3

0

High-throughput

0.634

High

1391003

CHTOP
Chromatin target of PRMT1 protein

3

0

Small-scale

0.626

High

1061092

SRSF1
Serine/arginine-rich splicing factor 1

2

4

Small-scale

0.611

High

807528

IF4A3
Eukaryotic initiation factor 4A-III

2

0

Small-scale

0.602

High

1391004

RBM8A
RNA-binding protein 8A

2

1

Small-scale

0.588

High

1107106

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.586

High

272986

ZC11A
Zinc finger CCCH domain-containing protein 11A

2

0

High-throughput

0.585

High

286027

SF3B1
Splicing factor 3B subunit 1

2

0

Small-scale

0.585

High

1331932

CS047
Uncharacterized protein C19orf47

2

0

High-throughput

0.585

High

137262

EXOC5
Exocyst complex component 5

2

0

High-throughput

0.580

High

191933

MAGB4
Melanoma-associated antigen B4

2

0

High-throughput

0.580

High

283528

TAD2A
Transcriptional adapter 2-alpha

2

0

High-throughput

0.580

High

572130

TRI27
Zinc finger protein RFP

2

0

High-throughput

0.580

High

685305

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.580

High

1006284

CTG1B
Cancer/testis antigen 1

2

0

High-throughput

0.580

High

1048961

REL
Proto-oncogene c-Rel

2

0

High-throughput

0.580

High

1244632

GASP3
G protein-coupled receptor associated sorting protein 3

2

0

High-throughput

0.580

High

1390968

PP12C
Protein phosphatase 1 regulatory subunit 12C

2

0

High-throughput

0.580

High

1390967

TRI54
Tripartite motif-containing protein 54

1

2

High-throughput

0.573

High

988185

TRA2B
Transformer-2 protein homolog beta

2

3

Small-scale

0.571

High

1099013

SRSF9
Serine/arginine-rich splicing factor 9

2

2

Small-scale

0.571

High

589398

RFA2
Replication protein A 32 kDa subunit

2

0

High-throughput

0.559

High

696196

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

768876

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

1245406

ZC3HE
Zinc finger CCCH domain-containing protein 14

2

0

High-throughput

0.559

High

1111191

SNW1
SNW domain-containing protein 1

2

0

High-throughput

0.552

High

1390994

RABX5
Rab5 GDP/GTP exchange factor

1

0

High-throughput

0.549

High

134826

SAP18
Histone deacetylase complex subunit SAP18

2

0

Small-scale

0.547

High

980129

H4
Histone H4

2

0

Small-scale

0.547

High

1066743

NCBP1
Nuclear cap-binding protein subunit 1

2

0

Small-scale

0.547

High

1242421

RHGBA
Rho GTPase-activating protein 11A

2

0

High-throughput

0.547

High

861722

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

Small-scale

0.537

High

272726

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

2

High-throughput

0.536

High

900088

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.536

High

937318

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

High-throughput

0.536

High

1005490

RBM6
RNA-binding protein 6

1

1

High-throughput

0.536

High

1056900

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.536

High

1062590

DHX9
ATP-dependent RNA helicase A

1

1

High-throughput

0.536

High

1212018

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

2

High-throughput

0.536

High

1390966

PDIP3
Polymerase delta-interacting protein 3

1

2

High-throughput

0.536

High

1390973

SFR19
Splicing factor, arginine/serine-rich 19

1

1

High-throughput

0.536

High

1390975

SP110
Sp110 nuclear body protein

1

1

High-throughput

0.536

High

1390977

DDX21
Nucleolar RNA helicase 2

1

1

High-throughput

0.536

High

1390982

BCLF1
Bcl-2-associated transcription factor 1

1

3

High-throughput

0.536

High

1390987

RBM27
RNA-binding protein 27

1

1

High-throughput

0.536

High

1391000

TR150
Thyroid hormone receptor-associated protein 3

1

3

High-throughput

0.536

High

1330052

USBP1
Harmonin-binding protein USHBP1

1

1

High-throughput

0.523

High

1245291

Q6PJH3
A kinase

1

1

High-throughput

0.515

High

60516

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

1

0

High-throughput

0.513

High

130575

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.513

High

230560

KIF1C
Kinesin-like protein KIF1C

1

0

High-throughput

0.513

High

244756

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.513

High

275992

DUS11
RNA/RNP complex-1-interacting phosphatase

1

0

High-throughput

0.513

High

352515

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.513

High

354756

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.513

High

442437

GELS
Gelsolin

1

0

High-throughput

0.513

High

471182

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.513

High

478155

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

480265

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

542159

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

574419

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

788143

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

854222

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

974012

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

1022093

TSG6
Tumor necrosis factor-inducible gene 6 protein

1

0

High-throughput

0.513

High

1065357

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1109194

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

0

High-throughput

0.513

High

1127077

RBM39
RNA-binding protein 39

1

0

High-throughput

0.513

High

1149158

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.513

High

1160244

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1256769

CCD9B
Coiled-coil domain-containing protein 9B

1

0

High-throughput

0.513

High

1313115

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.513

High

1336748

RB15B
Putative RNA-binding protein 15B

1

0

High-throughput

0.513

High

1361647

ATG4A
Cysteine protease ATG4A

1

0

High-throughput

0.513

High

1390958

PWP2A
PWWP domain-containing protein 2A

1

0

High-throughput

0.513

High

1390959

UIF
UAP56-interacting factor

1

0

High-throughput

0.513

High

1390961

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.513

High

1390972

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.513

High

1390974

CAAP1
Caspase activity and apoptosis inhibitor 1

1

0

High-throughput

0.513

High

1390983

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

1390986

BCCIP
BRCA2 and CDKN1A-interacting protein

1

0

High-throughput

0.513

High

1390989

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

1390998

RTRAF
RNA transcription, translation and transport factor protein

1

0

High-throughput

0.513

High

1391002

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.513

High

1095164

RED
Protein Red

1

1

High-throughput

0.508

High

1128082

DHX8
ATP-dependent RNA helicase DHX8

1

1

High-throughput

0.508

High

442789

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.504

High

1390979

RBM22
Pre-mRNA-splicing factor RBM22

1

0

High-throughput

0.493

High

1105372

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.486

High

1258746

F10C1
Protein FRA10AC1

1

0

High-throughput

0.486

High

1390963

MEP50
Methylosome protein WDR77

1

0

High-throughput

0.486

High

1390993

S30BP
SAP30-binding protein

1

0

High-throughput

0.486

High

1390962

AKAP9
A-kinase anchor protein 9

1

3

High-throughput

0.481

High

302610

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.479

High

346183

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

372827

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

406495

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

566798

PDIA4
Protein disulfide-isomerase A4

1

1

High-throughput

0.479

High

606996

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

617456

DNLI1
DNA ligase 1

1

1

High-throughput

0.479

High

775252

FUS
RNA-binding protein FUS

1

2

High-throughput

0.479

High

799388

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

935596

MFAP1
Microfibrillar-associated protein 1

1

1

Small-scale

0.479

High

1024758

VIGLN
Vigilin

1

1

High-throughput

0.479

High

1214659

RBM26
RNA-binding protein 26

1

1

High-throughput

0.479

High

1255036

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1290647

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

1313332

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1368857

RBP56
TATA-binding protein-associated factor 2N

1

1

High-throughput

0.479

High

1390960

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

961085

MGN
Protein mago nashi homolog

1

0

Small-scale

0.464

High

1015277

ERH
Enhancer of rudimentary homolog

1

0

Small-scale

0.464

High

1390965

SRRT
Serrate RNA effector molecule homolog

1

0

Small-scale

0.464

High

223249

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.460

High

321627

PRP6
Pre-mRNA-processing factor 6

1

0

High-throughput

0.460

High

1137654

EXOS7
Exosome complex component RRP42

1

0

High-throughput

0.460

High

1387389

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.460

High

1390988

TFP11
Tuftelin-interacting protein 11

1

0

High-throughput

0.460

High

129321

MEN1
Menin

1

0

High-throughput

0.458

High

136959

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

173736

BTAF1
TATA-binding protein-associated factor 172

1

0

High-throughput

0.458

High

191046

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

248039

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

260293

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

272382

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

287724

KS6A5
Ribosomal protein S6 kinase alpha-5

1

0

High-throughput

0.458

High

401289

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

459715

PROF1
Profilin-1

1

0

Small-scale

0.458

High

556945

MYH7
Myosin-7

1

0

High-throughput

0.458

High

594856

GCFC2
Intron Large complex component GCFC2

1

0

High-throughput

0.458

High

854905

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.458

High

905023

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

943296

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.458

High

961623

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.458

High

1034043

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.458

High

1132669

MEF2D
Myocyte-specific enhancer factor 2D

1

0

High-throughput

0.458

High

1135774

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1156814

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1279296

I2BP2
Interferon regulatory factor 2-binding protein 2

1

0

High-throughput

0.458

High

1279885

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

0

High-throughput

0.458

High

1323564

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

1367005

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1382815

FUBP1
Far upstream element-binding protein 1

1

0

High-throughput

0.458

High

1385600

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1390964

NADAP
Kanadaptin

1

0

High-throughput

0.458

High

1390969

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1390971

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1390976

ANLN
Anillin

1

0

High-throughput

0.458

High

1390980

AATF
Protein AATF

1

0

High-throughput

0.458

High

1390981

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1390985

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.458

High

1390992

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1390997

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.458

High

96821

E9PB61
Aly/REF export factor

1

2

High-throughput

0.445

High

114542

H0YHG0
DnaJ homolog subfamily C member 14

1

1

High-throughput

0.445

High

284207

SRS10
Serine/arginine-rich splicing factor 10

1

1

Small-scale

0.445

High

457615

TBB5
Tubulin beta chain

1

1

Small-scale

0.445

High

462565

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

4

Small-scale

0.445

High

996804

TBA1B
Tubulin alpha-1B chain

1

1

Small-scale

0.445

High

1016563

SRSF3
Serine/arginine-rich splicing factor 3

1

6

Small-scale

0.445

High

1062077

SRSF4
Serine/arginine-rich splicing factor 4

1

2

Small-scale

0.445

High

1118558

TBB2A
Tubulin beta-2A chain

1

1

Small-scale

0.445

High

1145320

RNPS1
RNA-binding protein with serine-rich domain 1

1

2

Small-scale

0.445

High

1148459

SAFB1
Scaffold attachment factor B1

1

1

Small-scale

0.445

High

1160038

SRSF7
Serine/arginine-rich splicing factor 7

1

5

Small-scale

0.445

High

1203222

ODFP2
Outer dense fiber protein 2

1

1

High-throughput

0.445

High

1292795

SKAP1
Src kinase-associated phosphoprotein 1

1

1

High-throughput

0.445

High

1390990

NXF1
Nuclear RNA export factor 1

1

1

Small-scale

0.445

High

1390995

RALY
RNA-binding protein Raly

1

1

Small-scale

0.445

High

822812

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.438

High

157725

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

1227243

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

1390999

RT17
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.437

High

472974

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

Small-scale

0.426

High

584131

FOSL2
Fos-related antigen 2

1

0

High-throughput

0.426

High

729401

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

0

Small-scale

0.426

High

846417

MATR3
Matrin-3

1

0

Small-scale

0.426

High

910629

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

Small-scale

0.426

High

911652

NCBP2
Nuclear cap-binding protein subunit 2

1

0

Small-scale

0.426

High

974637

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

Small-scale

0.426

High

996289

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.426

High

1017107

H33
Histone H3.3

1

0

Small-scale

0.426

High

1120283

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.426

High

1132410

CASP8
Caspase-8

1

0

High-throughput

0.426

High

1162865

H2A2C
Histone H2A type 2-C

1

0

Small-scale

0.426

High

1208871

H2B2F
Histone H2B type 2-F

1

0

Small-scale

0.426

High

1209505

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1390957

YTDC1
YTH domain-containing protein 1

1

0

Small-scale

0.426

High

1390984

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

High-throughput

0.426

High

1391001

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

Small-scale

0.426

High

116739

I3L0E3
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.407

High

353495

AGR2
Anterior gradient protein 2 homolog

2

0

High-throughput

0.316

High

1390970

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.316

High

207860

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

0

High-throughput

0.279

Low

1390991

B4GT7
Beta-1,4-galactosyltransferase 7

1

0

High-throughput

0.279

Low

880946

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.265

Low

1235251

ANO7
Anoctamin-7

1

0

Small-scale

0.249

Low

1390996

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1390978

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

62576

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

213225

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.232

Low

457981

TRY1
Serine protease 1

1

0

Small-scale

0.232

Low

915025

AK1C2
Aldo-keto reductase family 1 member C2

1

0

High-throughput

0.232

Low

1335673

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025