Protein: OTUL
Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby)

Gene: OTUL, OTULIN
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q96BN8

Gene Ontology (top 5):
GO:0002040 - sprouting angiogenesis
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508406

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

14

1

Small-scale

0.983

High

1384807

SNX27
Sorting nexin-27

5

4

Small-scale

0.938

High

159786

DVL2
Segment polarity protein dishevelled homolog DVL-2

3

1

Small-scale

0.850

High

1384805

RNF31
E3 ubiquitin-protein ligase RNF31

20

2

Small-scale

0.765

High

1150463

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

3

5

Small-scale

0.751

High

1384803

OTUL
Ubiquitin thioesterase otulin

2

0

Small-scale

0.728

High

1384815

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

6

1

Small-scale

0.721

High

1212231

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

4

High-throughput

0.705

High

1384817

SHRPN
Sharpin

5

1

Small-scale

0.702

High

162853

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

5

High-throughput

0.691

High

1139101

DAZP2
DAZ-associated protein 2

3

0

High-throughput

0.646

High

944412

SYJ2B
Synaptojanin-2-binding protein

1

1

High-throughput

0.618

High

242528

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.618

High

1104858

SNTB2
Beta-2-syntrophin

1

1

Small-scale

0.618

High

326762

DUS14
Dual specificity protein phosphatase 14

3

1

High-throughput

0.609

High

1322300

SPART
Spartin

2

1

High-throughput

0.606

High

1091962

SEC20
Vesicle transport protein SEC20

2

1

High-throughput

0.601

High

1122305

SCRIB
Protein scribble homolog

1

0

Small-scale

0.586

High

1154899

NEDD8
Ubiquitin-like protein NEDD8

1

0

Small-scale

0.586

High

1232978

OTU7B
OTU domain-containing protein 7B

2

0

High-throughput

0.580

High

1357630

SFT2A
Vesicle transport protein SFT2A

2

0

High-throughput

0.580

High

926820

VMAT1
Chromaffin granule amine transporter

2

2

High-throughput

0.574

High

1384811

TBA1C
Tubulin alpha-1C chain

2

1

Small-scale

0.571

High

934972

TERA
Transitional endoplasmic reticulum ATPase

2

1

Small-scale

0.563

High

827239

ARL1
ADP-ribosylation factor-like protein 1

2

0

Small-scale

0.559

High

564178

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

688608

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

1

High-throughput

0.536

High

956970

CXCR4
C-X-C chemokine receptor type 4

1

4

High-throughput

0.536

High

997925

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.536

High

1384809

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.536

High

71064

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

4

High-throughput

0.514

High

132942

ST1C2
Sulfotransferase 1C2

1

0

High-throughput

0.513

High

1114992

CUL4A
Cullin-4A

1

0

High-throughput

0.513

High

831205

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

209088

CYB5B
Cytochrome b5 type B

1

3

High-throughput

0.489

High

230718

NKG2F
NKG2-F type II integral membrane protein

1

1

High-throughput

0.489

High

754079

CD80
T-lymphocyte activation antigen CD80

1

4

High-throughput

0.489

High

835354

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

1

High-throughput

0.489

High

1053047

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.489

High

1240926

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.489

High

1286454

DSG4
Desmoglein-4

1

2

High-throughput

0.489

High

353886

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.480

High

384512

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.480

High

259031

DNJA2
DnaJ homolog subfamily A member 2

1

2

Small-scale

0.479

High

294141

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

469317

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

1

Small-scale

0.479

High

679229

DNJB1
DnaJ homolog subfamily B member 1

1

2

Small-scale

0.479

High

853506

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

2

Small-scale

0.479

High

891275

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.479

High

891724

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

1051037

FAK1
Focal adhesion kinase 1

1

1

Small-scale

0.479

High

1093394

TRI32
E3 ubiquitin-protein ligase TRIM32

1

1

Small-scale

0.479

High

1259406

TBA1A
Tubulin alpha-1A chain

1

1

Small-scale

0.479

High

1278916

BRAP
BRCA1-associated protein

1

5

Small-scale

0.479

High

1384810

DUS9
Dual specificity protein phosphatase 9

1

1

High-throughput

0.479

High

1384812

TMM43
Transmembrane protein 43

1

1

Small-scale

0.479

High

1384814

DUS23
Dual specificity protein phosphatase 23

1

3

High-throughput

0.479

High

1384816

OSBL8
Oxysterol-binding protein-related protein 8

1

6

Small-scale

0.479

High

1384820

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1384828

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

1

Small-scale

0.479

High

1384833

DDX20
Probable ATP-dependent RNA helicase DDX20

1

1

Small-scale

0.479

High

135672

DNM1L
Dynamin-1-like protein

1

0

Small-scale

0.458

High

138741

IMA4
Importin subunit alpha-4

1

0

Small-scale

0.458

High

160577

IRS4
Insulin receptor substrate 4

1

0

Small-scale

0.458

High

162114

ACOT8
Acyl-coenzyme A thioesterase 8

1

0

Small-scale

0.458

High

186661

HMGB3
High mobility group protein B3

1

0

Small-scale

0.458

High

253779

UGDH
UDP-glucose 6-dehydrogenase

1

0

Small-scale

0.458

High

258170

IF2P
Eukaryotic translation initiation factor 5B

1

0

Small-scale

0.458

High

270970

CLAP2
CLIP-associating protein 2

1

0

Small-scale

0.458

High

271558

ATG13
Autophagy-related protein 13

1

0

Small-scale

0.458

High

360069

NB5R3
NADH-cytochrome b5 reductase 3

1

0

Small-scale

0.458

High

408130

TBB4A
Tubulin beta-4A chain

1

0

Small-scale

0.458

High

537674

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

583882

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

0

Small-scale

0.458

High

633763

PSB1
Proteasome subunit beta type-1

1

0

Small-scale

0.458

High

663438

RIR1
Ribonucleoside-diphosphate reductase large subunit

1

0

Small-scale

0.458

High

724789

METK2
S-adenosylmethionine synthase isoform type-2

1

0

Small-scale

0.458

High

783638

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

0

Small-scale

0.458

High

838157

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.458

High

840080

CASP3
Caspase-3

1

0

Small-scale

0.458

High

861245

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

877195

KC1D
Casein kinase I isoform delta

1

0

Small-scale

0.458

High

890872

TSC2
Tuberin

1

0

Small-scale

0.458

High

899709

ANX11
Annexin A11

1

0

Small-scale

0.458

High

903626

GALK1
Galactokinase

1

0

Small-scale

0.458

High

914108

HXK2
Hexokinase-2

1

0

Small-scale

0.458

High

951801

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

976761

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

Small-scale

0.458

High

998159

PA1B2
Platelet-activating factor acetylhydrolase IB subunit alpha2

1

0

Small-scale

0.458

High

1031120

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

0

Small-scale

0.458

High

1054320

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

Small-scale

0.458

High

1094232

ACACA
Acetyl-CoA carboxylase 1

1

0

Small-scale

0.458

High

1098658

SBP1
Methanethiol oxidase

1

0

High-throughput

0.458

High

1124282

IF4A2
Eukaryotic initiation factor 4A-II

1

0

Small-scale

0.458

High

1129174

IRF3
Interferon regulatory factor 3

1

0

Small-scale

0.458

High

1129477

PUM1
Pumilio homolog 1

1

0

Small-scale

0.458

High

1158692

DPYL2
Dihydropyrimidinase-related protein 2

1

0

Small-scale

0.458

High

1177617

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

Small-scale

0.458

High

1178297

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1240419

MAST2
Microtubule-associated serine/threonine-protein kinase 2

1

0

Small-scale

0.458

High

1254975

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1323122

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.458

High

1353033

GEMI5
Gem-associated protein 5

1

0

Small-scale

0.458

High

1384804

RM38
Large ribosomal subunit protein mL38

1

0

Small-scale

0.458

High

1384806

PTCD3
Small ribosomal subunit protein mS39

1

0

Small-scale

0.458

High

1384808

WRIP1
ATPase WRNIP1

1

0

Small-scale

0.458

High

1384818

ZBP1
Z-DNA-binding protein 1

1

0

Small-scale

0.458

High

1384819

CPVL
Probable serine carboxypeptidase CPVL

1

0

Small-scale

0.458

High

1384822

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1384823

CYBP
Calcyclin-binding protein

1

0

Small-scale

0.458

High

1384825

PFD4
Prefoldin subunit 4

1

0

Small-scale

0.458

High

1384830

HDAC6
Protein deacetylase HDAC6

1

0

Small-scale

0.458

High

1384831

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

0

Small-scale

0.458

High

1384832

TES
Testin

1

0

High-throughput

0.458

High

1384834

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1384838

RT16
Small ribosomal subunit protein bS16m

1

0

Small-scale

0.458

High

1384839

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

Small-scale

0.458

High

638490

FPR1
fMet-Leu-Phe receptor

1

3

High-throughput

0.445

High

130202

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.437

High

181396

PGRC2
Membrane-associated progesterone receptor component 2

1

2

Small-scale

0.437

High

337793

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

Small-scale

0.437

High

598171

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

Small-scale

0.437

High

863532

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

Small-scale

0.437

High

1023379

AT2C1
Calcium-transporting ATPase type 2C member 1

1

2

Small-scale

0.437

High

1292047

THOC6
THO complex subunit 6

1

1

Small-scale

0.437

High

1338472

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

5

Small-scale

0.437

High

1353643

LRC15
Leucine-rich repeat-containing protein 15

1

1

High-throughput

0.437

High

273913

CNOT3
CCR4-NOT transcription complex subunit 3

1

0

High-throughput

0.426

High

133294

P2Y10
Putative P2Y purinoceptor 10

1

1

High-throughput

0.407

High

1238062

S18B1
MFS-type transporter SLC18B1

1

2

High-throughput

0.407

High

1260503

S35D2
Nucleotide sugar transporter SLC35D2

1

1

High-throughput

0.407

High

1381011

S35B4
Nucleotide sugar transporter SLC35B4

1

1

High-throughput

0.407

High

1384835

SPAT2
Spermatogenesis-associated protein 2

1

0

High-throughput

0.391

High

1364808

F168A
Protein FAM168A

3

0

High-throughput

0.352

High

378160

TNFA
Tumor necrosis factor

3

0

Small-scale

0.334

High

562298

LAMP2
Lysosome-associated membrane glycoprotein 2

2

0

High-throughput

0.328

High

1359024

TM239
Transmembrane protein 239

2

0

High-throughput

0.316

High

1363798

SUSD6
Sushi domain-containing protein 6

2

0

High-throughput

0.316

High

280944

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

427924

ICAM1
Intercellular adhesion molecule 1

1

0

High-throughput

0.279

Low

572949

INSRR
Insulin receptor-related protein

1

0

High-throughput

0.279

Low

1111176

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.279

Low

1384827

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

0

High-throughput

0.279

Low

1384829

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1384836

B3GT5
Beta-1,3-galactosyltransferase 5

1

0

High-throughput

0.279

Low

165636

SCAM3
Secretory carrier-associated membrane protein 3

1

0

Small-scale

0.249

Low

221629

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

Small-scale

0.249

Low

229782

CALU
Calumenin

1

0

Small-scale

0.249

Low

318039

TOM70
Mitochondrial import receptor subunit TOM70

1

0

Small-scale

0.249

Low

589360

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

702643

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

Small-scale

0.249

Low

716213

ERP29
Endoplasmic reticulum resident protein 29

1

0

Small-scale

0.249

Low

768843

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

941691

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

0

Small-scale

0.249

Low

961559

VA0D1
V-type proton ATPase subunit d 1

1

0

Small-scale

0.249

Low

1011339

RT25
Small ribosomal subunit protein mS25

1

0

Small-scale

0.249

Low

1011498

RT10
Small ribosomal subunit protein uS10m

1

0

Small-scale

0.249

Low

1121061

BOP1
Ribosome biogenesis protein BOP1

1

0

Small-scale

0.249

Low

1162205

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

Small-scale

0.249

Low

1187798

AL1L2
Mitochondrial 10-formyltetrahydrofolate dehydrogenase

1

0

Small-scale

0.249

Low

1192077

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

Small-scale

0.249

Low

1312162

NELFD
Negative elongation factor C/D

1

0

Small-scale

0.249

Low

1359874

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

Small-scale

0.249

Low

1381660

FAKD4
FAST kinase domain-containing protein 4

1

0

Small-scale

0.249

Low

1384813

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

Small-scale

0.249

Low

1384821

TFB2M
Dimethyladenosine transferase 2, mitochondrial

1

0

Small-scale

0.249

Low

1384824

TM9S3
Transmembrane 9 superfamily member 3

1

0

Small-scale

0.249

Low

1384826

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

1

0

Small-scale

0.249

Low

1384837

SF3B6
Splicing factor 3B subunit 6

1

0

Small-scale

0.249

Low

1384840

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

Small-scale

0.249

Low

925580

MOT1
Monocarboxylate transporter 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025