Protein: THOC5
THO complex subunit 5 (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90)

Gene: THOC5
Organism: Homo sapiens
Interactions: 119
UniProt ID: Q13769

Gene Ontology (top 5):
GO:0000346 - transcription export complex
GO:0000347 - THO complex
GO:0000445 - THO complex part of transcription export complex
GO:0003729 - mRNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1117203

THOC1
THO complex subunit 1

10

1

Small-scale

0.975

High

1117186

THOC7
THO complex subunit 7

4

2

Small-scale

0.895

High

1117176

DX39B
Spliceosome RNA helicase DDX39B

8

3

Small-scale

0.753

High

1117191

THOC4
THO complex subunit 4

7

2

Small-scale

0.745

High

1117195

THOC2
THO complex subunit 2

9

2

Small-scale

0.745

High

1117205

THOC3
THO complex subunit 3

6

3

Small-scale

0.733

High

914604

RM12
Large ribosomal subunit protein bL12m

3

0

High-throughput

0.634

High

1117231

CHTOP
Chromatin target of PRMT1 protein

3

0

Small-scale

0.622

High

1117184

NCBP3
Nuclear cap-binding protein subunit 3

3

0

High-throughput

0.616

High

1117193

THOC6
THO complex subunit 6

2

2

Small-scale

0.611

High

807411

IF4A3
Eukaryotic initiation factor 4A-III

2

0

Small-scale

0.576

High

1117226

NXF1
Nuclear RNA export factor 1

2

0

Small-scale

0.560

High

1117175

THOC5
THO complex subunit 5

1

0

Small-scale

0.546

High

123095

DX39A
ATP-dependent RNA helicase DDX39A

1

3

High-throughput

0.536

High

230529

KIF1C
Kinesin-like protein KIF1C

1

1

High-throughput

0.536

High

593365

PGFRA
Platelet-derived growth factor receptor alpha

1

1

High-throughput

0.536

High

1117199

MGN2
Protein mago nashi homolog 2

1

1

High-throughput

0.536

High

1117216

PDIP3
Polymerase delta-interacting protein 3

1

2

High-throughput

0.536

High

1117222

BCLF1
Bcl-2-associated transcription factor 1

1

1

High-throughput

0.536

High

892679

DNLI4
DNA ligase 4

1

0

High-throughput

0.529

High

997702

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.527

High

415551

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

72703

MYO1G
Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2

1

0

High-throughput

0.513

High

272929

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.513

High

478036

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

480132

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

542008

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

574262

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

770177

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.513

High

770383

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.513

High

854044

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

858921

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

1013133

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.513

High

1039207

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.513

High

1044342

HSF2
Heat shock factor protein 2

1

0

High-throughput

0.513

High

1065184

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1117178

RBM39
RNA-binding protein 39

1

0

High-throughput

0.513

High

1117181

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.513

High

1117183

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1117188

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

0

High-throughput

0.513

High

1117189

WDR74
WD repeat-containing protein 74

1

0

High-throughput

0.513

High

1117194

CS047
Uncharacterized protein C19orf47

1

0

High-throughput

0.513

High

1117196

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.513

High

1117201

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

High-throughput

0.513

High

1117202

RBM33
RNA-binding protein 33

1

0

High-throughput

0.513

High

1117208

SPB12
Serpin B12

1

0

High-throughput

0.513

High

1117209

UIF
UAP56-interacting factor

1

0

High-throughput

0.513

High

1117213

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.513

High

974241

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

1

High-throughput

0.508

High

1117206

ZN830
Zinc finger protein 830

1

0

High-throughput

0.486

High

1117229

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

0

High-throughput

0.486

High

606742

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

775073

FUS
RNA-binding protein FUS

1

3

High-throughput

0.479

High

1024563

VIGLN
Vigilin

1

1

High-throughput

0.479

High

1117180

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1117198

RBP56
TATA-binding protein-associated factor 2N

1

1

High-throughput

0.479

High

1117204

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

1

High-throughput

0.479

High

1117217

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.479

High

134727

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

223019

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

241631

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

247888

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

259922

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

342862

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

345785

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

400805

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

406158

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.458

High

472723

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

588653

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

695413

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

768144

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

854846

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.458

High

904690

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

970468

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

979627

H4
Histone H4

1

0

High-throughput

0.458

High

1066636

NCBP1
Nuclear cap-binding protein subunit 1

1

0

Small-scale

0.458

High

1117182

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1117190

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1117197

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1117200

FUBP1
Far upstream element-binding protein 1

1

0

High-throughput

0.458

High

1117210

NEB2
Neurabin-2

1

0

High-throughput

0.458

High

1117211

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.458

High

1117212

ZN649
Zinc finger protein 649

1

0

High-throughput

0.458

High

1117215

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1117218

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1117219

ANLN
Anillin

1

0

High-throughput

0.458

High

1117220

DJC17
DnaJ homolog subfamily C member 17

1

0

High-throughput

0.458

High

1117221

AATF
Protein AATF

1

0

High-throughput

0.458

High

1117223

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1117224

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.458

High

1117227

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1117228

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

0

High-throughput

0.458

High

961024

MGN
Protein mago nashi homolog

1

1

Small-scale

0.445

High

1117232

RBM8A
RNA-binding protein 8A

1

2

Small-scale

0.445

High

1117207

CF418
Cilia- and flagella-associated protein 418

1

0

Small-scale

0.438

High

1117192

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.437

High

251303

NEMF
Ribosome quality control complex subunit NEMF

1

0

High-throughput

0.426

High

839006

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.426

High

911579

NCBP2
Nuclear cap-binding protein subunit 2

1

0

High-throughput

0.426

High

1015202

ERH
Enhancer of rudimentary homolog

1

0

Small-scale

0.426

High

1117177

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1117179

CASP8
Caspase-8

1

0

High-throughput

0.426

High

1117185

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.426

High

1117214

SRRT
Serrate RNA effector molecule homolog

1

0

Small-scale

0.426

High

96816

E9PB61
Aly/REF export factor

1

2

High-throughput

0.407

High

108085

G3V529
ATP-dependent RNA helicase

1

1

High-throughput

0.407

High

114449

H0Y714
IMP U3 small nucleolar ribonucleoprotein 4

1

1

High-throughput

0.407

High

114452

H0Y7U4
THO complex subunit 2

1

1

High-throughput

0.407

High

1043122

TAP1
Antigen peptide transporter 1

1

0

Small-scale

0.288

High

720716

OXYR
Oxytocin receptor

1

0

High-throughput

0.282

High

337590

FMNL1
Formin-like protein 1

1

0

High-throughput

0.279

Low

1022081

TSG6
Tumor necrosis factor-inducible gene 6 protein

1

0

High-throughput

0.279

Low

1117225

NHSL3
NHS-like protein 3

1

0

High-throughput

0.279

Low

1117230

CCDC9
Coiled-coil domain-containing protein 9

1

0

High-throughput

0.279

Low

105899

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

157345

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

1117187

ANO7
Anoctamin-7

1

0

Small-scale

0.249

Low

915023

AK1C2
Aldo-keto reductase family 1 member C2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025