Protein: TIFA
TRAF-interacting protein with FHA domain-containing protein A (Putative MAPK-activating protein PM14) (Putative NF-kappa-B-activating protein 20) (TRAF2-binding protein)

Gene: TIFA
Organism: Homo sapiens
Interactions: 41
UniProt ID: Q96CG3

Gene Ontology (top 5):
GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0033209 - tumor necrosis factor-mediated signaling pathway
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1253200

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

2

2

Small-scale

0.754

High

1090845

TRAF2
TNF receptor-associated factor 2

9

5

Small-scale

0.754

High

930774

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

0

High-throughput

0.742

High

1385943

TIFA
TRAF-interacting protein with FHA domain-containing protein A

2

2

Small-scale

0.737

High

1385953

TRAF6
TNF receptor-associated factor 6

6

7

Small-scale

0.737

High

140394

SDCB1
Syntenin-1

4

2

High-throughput

0.707

High

1385951

SDCB2
Syntenin-2

3

3

High-throughput

0.688

High

1326795

ARG39
Rho guanine nucleotide exchange factor 39

2

0

High-throughput

0.678

High

1385949

AP1M1
AP-1 complex subunit mu-1

4

0

High-throughput

0.675

High

749098

RL9
Large ribosomal subunit protein uL6

3

0

High-throughput

0.646

High

1385952

NXF1
Nuclear RNA export factor 1

3

0

High-throughput

0.646

High

905641

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

Small-scale

0.618

High

159789

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

0

High-throughput

0.613

High

1348410

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.608

High

248926

GSDME
Gasdermin-E

2

0

High-throughput

0.580

High

1225038

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

0

High-throughput

0.580

High

1385945

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1093910

TRAF1
TNF receptor-associated factor 1

1

5

High-throughput

0.560

High

1107450

BIRC2
Baculoviral IAP repeat-containing protein 2

2

0

Small-scale

0.559

High

335290

TFIP8
Tumor necrosis factor alpha-induced protein 8

1

0

High-throughput

0.549

High

639285

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

0

Small-scale

0.537

High

1256873

NUD18
8-oxo-dGDP phosphatase NUDT18

1

0

High-throughput

0.518

High

1385950

NIF3L
NIF3-like protein 1

1

0

High-throughput

0.518

High

718446

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.513

High

1325745

LNX2
Ligand of Numb protein X 2

1

1

High-throughput

0.512

High

1215415

TUT4
Terminal uridylyltransferase 4

1

0

Small-scale

0.493

High

1385946

ALPK1
Alpha-protein kinase 1

1

0

Small-scale

0.480

High

1094949

TRAF3
TNF receptor-associated factor 3

1

7

Small-scale

0.479

High

1098087

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

Small-scale

0.479

High

1385947

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

2

Small-scale

0.479

High

508410

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

540616

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

Small-scale

0.458

High

879347

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

Small-scale

0.458

High

1290928

TAXB1
Tax1-binding protein 1

1

0

Small-scale

0.458

High

1385944

OPTN
Optineurin

1

0

Small-scale

0.458

High

943492

DSCR6
Protein ripply3

3

0

High-throughput

0.346

High

1339387

GP156
Probable G-protein coupled receptor 156

2

0

High-throughput

0.328

High

1385948

THIOM
Thioredoxin, mitochondrial

1

0

High-throughput

0.299

High

591775

H2AX
Histone H2AX

1

0

Small-scale

0.249

Low

926679

HIRA
Protein HIRA

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025