Protein: P5CR
Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2)

Gene: P5CR, PRO3
Organism: Saccharomyces cerevisiae S288C
Interactions: 70
UniProt ID: P32263

Gene Ontology (top 5):
GO:0004735 - pyrroline-5-carboxylate reductase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0042802 - identical protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

733574

P5CR
Pyrroline-5-carboxylate reductase

3

14

High-throughput

0.856

High

733588

COPB2
Coatomer subunit beta'

3

2

High-throughput

0.611

High

733576

EI2BB
Translation initiation factor eIF2B subunit beta

2

0

High-throughput

0.598

High

733589

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

523315

HSP71
Heat shock protein SSA1

2

2

High-throughput

0.552

High

544113

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

High-throughput

0.552

High

733585

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.552

High

449084

CALM
Calmodulin

1

0

Small-scale

0.537

High

733594

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

733595

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

733581

ATX1
Copper chaperone ATX1

1

0

High-throughput

0.518

High

733606

MEX67
mRNA export factor MEX67

1

0

High-throughput

0.518

High

733575

EF2
Elongation factor 2

1

3

High-throughput

0.515

High

670231

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.493

High

359439

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

1

High-throughput

0.479

High

367715

ENO1
Enolase 1

1

2

High-throughput

0.479

High

367925

ENO2
Enolase 2

1

2

High-throughput

0.479

High

392387

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

502910

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.479

High

579014

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

726822

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

733582

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

733593

HST2
NAD-dependent protein deacetylase HST2

1

3

High-throughput

0.479

High

733587

MAM33
Mitochondrial acidic protein MAM33

1

2

High-throughput

0.470

High

649211

SAN1
Protein SAN1

1

0

Small-scale

0.460

High

149643

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

364970

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.458

High

365582

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

368622

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.458

High

383579

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

409993

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

416529

HXKB
Hexokinase-2

1

0

High-throughput

0.458

High

434914

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

454932

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

504094

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

514513

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

555032

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

674476

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

689324

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

733578

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

733579

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

733580

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

733583

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

733591

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

733592

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

733596

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

733597

COFI
Cofilin

1

0

High-throughput

0.458

High

733598

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

733599

POC1
Proteasome chaperone 1

1

0

High-throughput

0.458

High

733600

SGO1
Shugoshin

1

0

High-throughput

0.458

High

733602

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

733604

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

510282

HSP77
Import motor subunit, mitochondrial

1

3

High-throughput

0.445

High

526140

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

671592

SCJ1
DnaJ-related protein SCJ1

1

3

High-throughput

0.445

High

733577

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

682198

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.437

High

733603

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.437

High

733605

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

386616

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

394333

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

592082

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

733590

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

733586

JEM1
DnaJ-like chaperone JEM1

1

5

High-throughput

0.407

High

506366

NFT1
ABC transporter NFT1

1

0

High-throughput

0.282

High

733584

SHO1
High osmolarity signaling protein SHO1

1

0

Small-scale

0.269

Low

733601

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.261

Low

506389

YK104
Putative uncharacterized protein YKR104W

1

0

High-throughput

0.251

Low

706451

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025