Protein: SHO1
High osmolarity signaling protein SHO1 (Osmosensor SHO1) (Suppressor of SUA8-1 mutation) (Synthetic high osmolarity-sensitive protein 1)

Gene: SHO1
Organism: Saccharomyces cerevisiae S288C
Interactions: 136
UniProt ID: P40073

Gene Ontology (top 5):
GO:0001402 - signal transduction involved in filamentous growth
GO:0005034 - osmosensor activity
GO:0005078 - MAP-kinase scaffold activity
GO:0005783 - endoplasmic reticulum
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

818101

SHO1
High osmolarity signaling protein SHO1

6

0

Small-scale

0.890

High

548276

FUS1
Nuclear fusion protein FUS1

4

0

Small-scale

0.867

High

818130

INN1
Ingression protein 1

2

0

Small-scale

0.788

High

818143

TUS1
Rho1 guanine nucleotide exchange factor TUS1

2

0

High-throughput

0.775

High

811265

RGA1
Rho-type GTPase-activating protein 1

2

0

High-throughput

0.759

High

464603

PBS2
MAP kinase kinase PBS2

11

0

Small-scale

0.727

High

734515

MSB2
Signaling mucin MSB2

5

1

Small-scale

0.707

High

818156

LAS17
Proline-rich protein LAS17

4

1

Small-scale

0.703

High

660327

STE11
Serine/threonine-protein kinase STE11

4

0

Small-scale

0.676

High

744856

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

0

High-throughput

0.663

High

672416

STE50
Protein STE50

3

0

Small-scale

0.636

High

818146

OPY2
Protein OPY2

3

0

Small-scale

0.636

High

818147

YD073
UPF0592 protein YDL073W

3

0

Small-scale

0.634

High

665827

KPC1
Protein kinase C-like 1

1

0

High-throughput

0.622

High

816024

BOI2
BEM1-interacting protein 2

1

0

High-throughput

0.622

High

818140

MYO5
Myosin-5

1

0

High-throughput

0.622

High

818142

CYK2
Cytokinesis protein 2

2

0

Small-scale

0.616

High

818148

CYK3
Cytokinesis protein 3

2

0

Small-scale

0.616

High

818114

HKR1
Signaling mucin HKR1

2

1

Small-scale

0.601

High

560707

KIN2
Serine/threonine-protein kinase KIN2

2

0

High-throughput

0.594

High

781700

BCH2
Protein BCH2

2

0

High-throughput

0.593

High

818138

STE20
Serine/threonine-protein kinase STE20

2

0

Small-scale

0.588

High

484300

KEX1
Pheromone-processing carboxypeptidase KEX1

2

0

High-throughput

0.587

High

712793

CHS3
Chitin synthase 3

2

0

Small-scale

0.587

High

542968

CDC24
Cell division control protein 24

1

0

Small-scale

0.586

High

803354

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

0

High-throughput

0.584

High

818123

LCL3
Probable endonuclease LCL3

2

0

High-throughput

0.577

High

818136

ATN2
Sodium/potassium exporting P-type ATPase 2

1

2

Small-scale

0.568

High

744512

FLO1
Flocculation protein FLO1

1

2

Small-scale

0.552

High

806916

FLO5
Flocculation protein FLO5

1

3

Small-scale

0.552

High

818120

DAN4
Cell wall protein DAN4

1

1

Small-scale

0.552

High

818139

SIZ1
E3 SUMO-protein ligase SIZ1

1

1

Small-scale

0.552

High

817398

GIP2
GLC7-interacting protein 2

2

1

High-throughput

0.550

High

359243

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

0

Small-scale

0.543

High

637831

MSB1
Morphogenesis-related protein MSB1

1

0

Small-scale

0.543

High

663316

FPS1
Glycerol uptake/efflux facilitator protein

1

0

Small-scale

0.543

High

818132

PMP3
Plasma membrane proteolipid 3

1

0

Small-scale

0.543

High

818134

SED1
Cell wall protein SED1

1

0

Small-scale

0.543

High

818149

ENT4
Epsin-4

1

0

Small-scale

0.543

High

392806

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.541

High

802992

COS8
Protein COS8

1

2

High-throughput

0.541

High

818126

COS6
Protein COS6

1

2

High-throughput

0.541

High

743392

TOR2
Serine/threonine-protein kinase TOR2

1

0

Small-scale

0.529

High

509575

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

Small-scale

0.519

High

577143

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.518

High

592770

ERD1
Protein ERD1

1

0

High-throughput

0.518

High

736188

YBT1
ATP-dependent bile acid permease

1

0

High-throughput

0.518

High

779905

MCH2
Probable transporter MCH2

1

0

High-throughput

0.518

High

805883

YHU0
UPF0641 membrane protein YHR140W

1

0

High-throughput

0.518

High

813683

SEO1
Probable transporter SEO1

1

0

High-throughput

0.518

High

814180

SEC72
Translocation protein SEC72

1

0

High-throughput

0.518

High

818079

TMN3
Transmembrane 9 superfamily member 3

1

0

High-throughput

0.518

High

818104

ELO3
Fatty acid elongase 3

1

0

High-throughput

0.518

High

818106

GPI7
GPI ethanolamine phosphate transferase 2

1

0

High-throughput

0.518

High

818145

BSP1
F-actin capping regulator BSP1

1

0

High-throughput

0.518

High

818151

SRO7
Lethal(2) giant larvae protein homolog SRO7

1

0

Small-scale

0.518

High

818154

DGK1
CTP-dependent diacylglycerol kinase 1

1

0

High-throughput

0.518

High

818155

RTN2
Reticulon-like protein 2

1

0

High-throughput

0.518

High

818157

ATN5
Sodium/potassium exporting P-type ATPase 5

1

2

Small-scale

0.515

High

818133

RHO4
GTP-binding protein RHO4

1

1

High-throughput

0.501

High

818117

COS4
Protein COS4

1

2

High-throughput

0.494

High

365061

KPYK1
Pyruvate kinase 1

1

0

Small-scale

0.493

High

365631

PGK
Phosphoglycerate kinase

1

0

Small-scale

0.493

High

656787

KC12
Casein kinase I homolog 2

1

0

Small-scale

0.493

High

780932

DCW1
Mannan endo-1,6-alpha-mannosidase DCW1

1

0

Small-scale

0.493

High

550585

SST2
Protein SST2

1

0

Small-scale

0.486

High

736983

CDC3
Cell division control protein 3

1

0

High-throughput

0.486

High

564782

ATN1
Sodium/potassium exporting P-type ATPase 1

1

2

Small-scale

0.481

High

818129

WSC2
Cell wall integrity and stress response component 2

1

1

Small-scale

0.481

High

737872

HOG1
Mitogen-activated protein kinase HOG1

1

0

Small-scale

0.480

High

818110

PRK1
Actin-regulating kinase PRK1

1

0

High-throughput

0.480

High

818111

AIM21
Altered inheritance of mitochondria protein 21

1

0

High-throughput

0.480

High

818135

MDM1
Structural protein MDM1

1

0

High-throughput

0.480

High

818150

NBA1
Protein NBA1

1

0

High-throughput

0.480

High

448541

RHO1
GTP-binding protein RHO1

1

0

Small-scale

0.460

High

506226

GMT2
Probable GDP-mannose transporter 2

1

0

High-throughput

0.460

High

677729

GEX1
Glutathione exchanger 1

1

0

Small-scale

0.460

High

618350

CDC42
Cell division control protein 42

1

0

Small-scale

0.458

High

809150

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

Small-scale

0.458

High

818113

BUD8
Bud site selection protein 8

1

0

Small-scale

0.458

High

818103

PIG2
GSY2-interacting protein PIG2

1

1

High-throughput

0.457

High

579478

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.445

High

358232

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.426

High

817575

UTP7
U3 small nucleolar RNA-associated protein 7

2

0

High-throughput

0.323

High

811210

PCF11
Protein PCF11

2

0

High-throughput

0.314

High

790418

GLY1
Low specificity L-threonine aldolase

1

0

Small-scale

0.296

High

802941

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

Small-scale

0.296

High

818102

MGDP1
Putative magnesium-dependent phosphatase YER134C

1

0

Small-scale

0.296

High

818115

AAD14
Putative aryl-alcohol dehydrogenase AAD14

1

0

High-throughput

0.296

High

818131

DIA1
Protein DIA1

1

0

Small-scale

0.296

High

818152

HOSM
Homocitrate synthase, mitochondrial

1

0

Small-scale

0.296

High

818153

PUF2
mRNA-binding protein PUF2

1

0

Small-scale

0.296

High

666661

AP2
AP-1-like transcription factor YAP2

1

0

Small-scale

0.288

High

737612

HS150
Cell wall mannoprotein HSP150

1

0

Small-scale

0.288

High

666473

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.282

High

673183

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.282

High

763686

GCS1
ADP-ribosylation factor GTPase-activating protein GCS1

1

0

High-throughput

0.282

High

805933

DSE2
Protein DSE2

1

0

High-throughput

0.282

High

818108

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

High-throughput

0.282

High

818109

NDC80
Kinetochore protein NDC80

1

0

High-throughput

0.282

High

818119

YJ85
Uncharacterized protein YJR115W

1

0

High-throughput

0.282

High

818121

AVT4
Vacuolar amino acid transporter 4

1

0

High-throughput

0.282

High

818122

MCM6
DNA replication licensing factor MCM6

1

0

High-throughput

0.282

High

818125

MTM1
Mitochondrial carrier protein MTM1

1

0

High-throughput

0.282

High

818141

KAR5
Nuclear fusion protein KAR5

1

0

High-throughput

0.282

High

572594

ALF
Fructose-bisphosphate aldolase

1

0

Small-scale

0.269

Low

598870

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

0

Small-scale

0.269

Low

733584

P5CR
Pyrroline-5-carboxylate reductase

1

0

Small-scale

0.269

Low

733661

GLNA
Glutamine synthetase

1

0

Small-scale

0.269

Low

818107

TPM2
Tropomyosin-2

1

0

Small-scale

0.269

Low

818116

CWP2
Cell wall protein CWP2

1

0

Small-scale

0.269

Low

452738

ADR1
Regulatory protein ADR1

1

0

High-throughput

0.265

Low

615017

GLN3
Nitrogen regulatory protein GLN3

1

0

High-throughput

0.265

Low

645435

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.265

Low

664495

SEC14
SEC14 cytosolic factor

1

0

High-throughput

0.265

Low

736828

ATP11
Protein ATP11, mitochondrial

1

0

High-throughput

0.265

Low

818118

SAC3
Nuclear mRNA export protein SAC3

1

0

High-throughput

0.265

Low

818124

PBP1
PAB1-binding protein 1

1

0

High-throughput

0.265

Low

818127

THO2
THO complex subunit 2

1

0

High-throughput

0.265

Low

736772

ASF2
Anti-silencing protein 2

1

0

High-throughput

0.261

Low

780662

SRX1
Sulfiredoxin

1

0

High-throughput

0.261

Low

818112

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.261

Low

818128

YN93
Uncharacterized hydrolase YNR064C

1

0

High-throughput

0.261

Low

818144

SUE1
Protein SUE1, mitochondrial

1

0

High-throughput

0.261

Low

712759

PTP2
Tyrosine-protein phosphatase 2

1

0

Small-scale

0.251

Low

813879

BOL3
BolA-like protein 3

1

0

Small-scale

0.251

Low

818105

ATAD2
ATPase histone chaperone YTA7

1

0

Small-scale

0.251

Low

818158

YH048
Uncharacterized protein YHL048C-A

1

0

Small-scale

0.251

Low

818159

YL154
Uncharacterized protein YLR154C-G

1

0

Small-scale

0.251

Low

707222

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

818137

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.249

Low

394604

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

439351

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.232

Low

554931

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.232

Low

597470

EF3A
Elongation factor 3A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025