Protein: S61A2
Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2)

Gene: S61A2, SEC61A2
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q9H9S3

Gene Ontology (top 5):
GO:0005048 - signal sequence binding
GO:0005784 - Sec61 translocon complex
GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0008320 - protein transmembrane transporter activity
GO:0031204 - post-translational protein targeting to membrane, translocation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

951437

SC61B
Protein transport protein Sec61 subunit beta

2

6

High-throughput

0.802

High

1437258

SEC63
Translocation protein SEC63 homolog

1

6

High-throughput

0.665

High

963136

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

2

High-throughput

0.618

High

401505

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

1

High-throughput

0.569

High

932599

PTN5
Tyrosine-protein phosphatase non-receptor type 5

2

3

High-throughput

0.558

High

564385

CFTR
Cystic fibrosis transmembrane conductance regulator

2

3

High-throughput

0.549

High

1382200

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

182779

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

323000

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

2

High-throughput

0.489

High

1101193

CLN3
Battenin

1

1

High-throughput

0.489

High

1279550

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

1

High-throughput

0.489

High

1314549

TM192
Transmembrane protein 192

1

1

High-throughput

0.489

High

1434640

SG196
Protein O-mannose kinase

1

1

High-throughput

0.489

High

1437259

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

1

High-throughput

0.489

High

1384083

TOM6
Mitochondrial import receptor subunit TOM6 homolog

1

1

High-throughput

0.439

High

294342

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

658982

PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

1

1

High-throughput

0.437

High

766865

PHB1
Prohibitin 1

1

1

High-throughput

0.437

High

1114335

CUL3
Cullin-3

1

1

High-throughput

0.437

High

1138072

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.437

High

1155784

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

1163814

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

1

High-throughput

0.437

High

1164084

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

4

High-throughput

0.437

High

1178385

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1255589

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1397439

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.437

High

1433924

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1437257

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.437

High

870418

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

1

High-throughput

0.407

High

923439

SC5A3
Sodium/myo-inositol cotransporter

1

3

High-throughput

0.407

High

1157200

S15A2
Solute carrier family 15 member 2

1

1

High-throughput

0.407

High

1178994

SC5A9
Sodium/glucose cotransporter 4

1

3

High-throughput

0.407

High

1227486

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

1291767

S22AG
Solute carrier family 22 member 16

1

2

High-throughput

0.407

High

1335726

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

469549

SYPH
Synaptophysin

1

0

High-throughput

0.279

Low

618423

TSN8
Tetraspanin-8

1

0

High-throughput

0.279

Low

733077

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.279

Low

845138

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.279

Low

1086110

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.279

Low

1325922

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1336528

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.279

Low

1363230

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

1399616

OPALI
Opalin

1

0

High-throughput

0.279

Low

157865

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

593219

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.249

Low

787249

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.249

Low

1327204

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025