Protein: JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR)

Gene: JMJD6
Organism: Homo sapiens
Interactions: 202
UniProt ID: Q6NYC1

Gene Ontology (top 5):
GO:0001822 - kidney development
GO:0002040 - sprouting angiogenesis
GO:0003723 - RNA binding
GO:0003727 - single-stranded RNA binding
GO:0005506 - iron ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1157392

PHRF1
PHD and RING finger domain-containing protein 1

3

5

Small-scale

0.770

High

244573

BRD4
Bromodomain-containing protein 4

10

11

Small-scale

0.759

High

1157403

LC7L2
Putative RNA-binding protein Luc7-like 2

5

2

Small-scale

0.716

High

1084491

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

4

8

Small-scale

0.702

High

263682

PR40A
Pre-mRNA-processing factor 40 homolog A

4

7

Small-scale

0.694

High

1157368

DIDO1
Death-inducer obliterator 1

1

4

High-throughput

0.691

High

1054383

RBM39
RNA-binding protein 39

4

5

Small-scale

0.691

High

1157359

RSRC1
Serine/Arginine-related protein 53

5

0

Small-scale

0.687

High

963227

U2AF1
Splicing factor U2AF 35 kDa subunit

3

2

High-throughput

0.683

High

1157385

ZCC17
Zinc finger CCHC domain-containing protein 17

3

1

High-throughput

0.683

High

1157341

PR38A
Pre-mRNA-splicing factor 38A

4

0

Small-scale

0.675

High

1157374

NAA50
N-alpha-acetyltransferase 50

3

1

High-throughput

0.675

High

834066

CLK3
Dual specificity protein kinase CLK3

3

5

High-throughput

0.675

High

1157337

NKAP
NF-kappa-B-activating protein

3

1

High-throughput

0.675

High

1157400

CCNL1
Cyclin-L1

3

2

High-throughput

0.674

High

262485

TULP3
Tubby-related protein 3

3

1

High-throughput

0.667

High

833456

RBM25
RNA-binding protein 25

3

1

Small-scale

0.667

High

984089

SRS11
Serine/arginine-rich splicing factor 11

3

1

Small-scale

0.667

High

1018401

SFSWA
Splicing factor, suppressor of white-apricot homolog

3

2

Small-scale

0.667

High

1055395

DHX8
ATP-dependent RNA helicase DHX8

3

7

High-throughput

0.667

High

1077203

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

3

2

High-throughput

0.667

High

1157330

RBM23
Probable RNA-binding protein 23

3

4

Small-scale

0.667

High

1157333

DHX40
Probable ATP-dependent RNA helicase DHX40

3

7

High-throughput

0.667

High

1157364

CCNL2
Cyclin-L2

3

2

Small-scale

0.667

High

1157382

CLK4
Dual specificity protein kinase CLK4

3

5

Small-scale

0.667

High

1157335

FAM9A
Protein FAM9A

3

2

High-throughput

0.664

High

1157398

PUF60
Poly(U)-binding-splicing factor PUF60

3

5

Small-scale

0.662

High

1157321

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

3

Small-scale

0.647

High

1146412

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

3

0

High-throughput

0.638

High

1148574

CDCA2
Cell division cycle-associated protein 2

3

0

Small-scale

0.638

High

1157329

RSRC2
Arginine/serine-rich coiled-coil protein 2

3

0

Small-scale

0.638

High

1157348

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

3

0

High-throughput

0.638

High

1157375

NSRP1
Nuclear speckle splicing regulatory protein 1

3

0

Small-scale

0.638

High

1157389

ARGL1
Arginine and glutamate-rich protein 1

3

0

High-throughput

0.638

High

1157386

LUC7L
Putative RNA-binding protein Luc7-like 1

4

2

Small-scale

0.633

High

165506

SR140
U2 snRNP-associated SURP motif-containing protein

2

2

High-throughput

0.628

High

304630

SCAF4
SR-related and CTD-associated factor 4

2

4

High-throughput

0.628

High

308218

LC7L3
Luc7-like protein 3

2

2

High-throughput

0.628

High

317835

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

2

1

High-throughput

0.628

High

596772

CD11B
Cyclin-dependent kinase 11B

2

7

High-throughput

0.628

High

641824

U2AF2
Splicing factor U2AF 65 kDa subunit

2

7

High-throughput

0.628

High

817685

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

2

High-throughput

0.628

High

968701

AK17A
A-kinase anchor protein 17A

2

1

High-throughput

0.628

High

1135190

RBM26
RNA-binding protein 26

2

3

High-throughput

0.628

High

1157328

DDX46
Probable ATP-dependent RNA helicase DDX46

2

5

High-throughput

0.628

High

1157332

CHERP
Calcium homeostasis endoplasmic reticulum protein

2

3

High-throughput

0.628

High

1157338

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

2

3

High-throughput

0.628

High

1157343

WDR48
WD repeat-containing protein 48

2

5

High-throughput

0.628

High

1157347

RN138
E3 ubiquitin-protein ligase RNF138

2

8

High-throughput

0.628

High

1157352

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

2

7

High-throughput

0.628

High

1157360

RNPC3
RNA-binding region-containing protein 3

2

1

High-throughput

0.628

High

1157365

SCAFB
Protein SCAF11

2

4

High-throughput

0.628

High

1157369

MMTA2
Multiple myeloma tumor-associated protein 2

2

1

High-throughput

0.628

High

1157373

WDR33
pre-mRNA 3' end processing protein WDR33

2

4

High-throughput

0.628

High

1157377

SFR19
Splicing factor, arginine/serine-rich 19

2

4

High-throughput

0.628

High

1157380

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

2

2

High-throughput

0.628

High

1157394

TFP11
Tuftelin-interacting protein 11

2

1

High-throughput

0.628

High

1157401

SCAF8
SR-related and CTD-associated factor 8

2

1

High-throughput

0.628

High

1157402

ZC3H4
Zinc finger CCCH domain-containing protein 4

2

2

High-throughput

0.628

High

1157404

RBMX2
RNA-binding motif protein, X-linked 2

2

5

High-throughput

0.628

High

1157406

HBS1L
HBS1-like protein

2

1

High-throughput

0.628

High

386930

P53
Cellular tumor antigen p53

1

2

Small-scale

0.612

High

1157358

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

2

1

High-throughput

0.611

High

214960

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

2

0

High-throughput

0.602

High

563621

ZNF24
Zinc finger protein 24

2

0

High-throughput

0.602

High

722613

T2FA
General transcription factor IIF subunit 1

2

0

High-throughput

0.602

High

1034001

PPIG
Peptidyl-prolyl cis-trans isomerase G

2

0

High-throughput

0.602

High

1081206

UAP1
UDP-N-acetylhexosamine pyrophosphorylase

2

0

High-throughput

0.602

High

1131583

ZMYM1
Zinc finger MYM-type protein 1

2

0

High-throughput

0.602

High

1138125

PR38B
Pre-mRNA-splicing factor 38B

2

0

High-throughput

0.602

High

1157345

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

2

0

High-throughput

0.602

High

1157346

CATIN
Splicing factor Cactin

2

0

High-throughput

0.602

High

1157395

IKBL1
NF-kappa-B inhibitor-like protein 1

2

0

High-throughput

0.602

High

1157409

PAXB1
PAX3- and PAX7-binding protein 1

2

0

High-throughput

0.602

High

369823

ESR1
Estrogen receptor

1

15

Small-scale

0.586

High

227788

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

631471

BRD2
Bromodomain-containing protein 2

2

17

High-throughput

0.584

High

1157327

NKAP1
Uncharacterized protein NKAPD1

2

1

High-throughput

0.574

High

1157362

FRMD6
FERM domain-containing protein 6

1

2

High-throughput

0.573

High

841775

CDK9
Cyclin-dependent kinase 9

1

8

Small-scale

0.561

High

1056426

IRF3
Interferon regulatory factor 3

1

1

Small-scale

0.561

High

1157366

RNF5
E3 ubiquitin-protein ligase RNF5

1

1

Small-scale

0.561

High

201604

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

1

High-throughput

0.536

High

225388

MED14
Mediator of RNA polymerase II transcription subunit 14

1

8

High-throughput

0.536

High

508572

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

559430

H13
Histone H1.3

1

3

High-throughput

0.536

High

577657

SON
Protein SON

1

1

High-throughput

0.536

High

720711

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.536

High

934245

CSK21
Casein kinase II subunit alpha

1

11

High-throughput

0.536

High

960140

CDKL1
Cyclin-dependent kinase-like 1

1

8

High-throughput

0.536

High

1049818

UBP2L
Ubiquitin-associated protein 2-like

1

6

High-throughput

0.536

High

1083180

U1SBP
U11/U12 small nuclear ribonucleoprotein 35 kDa protein

1

5

High-throughput

0.536

High

1157367

BUD13
BUD13 homolog

1

1

High-throughput

0.536

High

1157372

SETD2
Histone-lysine N-methyltransferase SETD2

1

3

High-throughput

0.536

High

1157383

PKHA2
Pleckstrin homology domain-containing family A member 2

1

1

High-throughput

0.536

High

1157393

RBM27
RNA-binding protein 27

1

1

High-throughput

0.536

High

1157399

DDX41
Probable ATP-dependent RNA helicase DDX41

1

4

High-throughput

0.536

High

48685

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.513

High

204681

E41L2
Band 4.1-like protein 2

1

0

High-throughput

0.513

High

235381

ADCY9
Adenylate cyclase type 9

1

0

High-throughput

0.513

High

242494

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

High-throughput

0.513

High

334358

AL1A1
Aldehyde dehydrogenase 1A1

1

0

High-throughput

0.513

High

828793

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

834490

HINT1
Adenosine 5'-monophosphoramidase HINT1

1

0

High-throughput

0.513

High

905661

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.513

High

1063145

SEPT2
Septin-2

1

0

High-throughput

0.513

High

1074858

TAF7
Transcription initiation factor TFIID subunit 7

1

0

High-throughput

0.513

High

1113944

RABL6
Rab-like protein 6

1

0

High-throughput

0.513

High

1157340

SYT2
Synaptotagmin-2

1

0

High-throughput

0.513

High

1157342

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.513

High

1157388

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.513

High

1157391

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.513

High

1157405

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.513

High

420845

H2B1J
Histone H2B type 1-J

1

7

High-throughput

0.508

High

906862

PRS4
26S proteasome regulatory subunit 4

1

2

High-throughput

0.508

High

1060308

NFIX
Nuclear factor 1 X-type

1

8

High-throughput

0.508

High

1116323

LARP7
La-related protein 7

1

7

High-throughput

0.508

High

1157323

AEBP2
Zinc finger protein AEBP2

1

3

High-throughput

0.508

High

1157334

SLN12
Ribonuclease SLFN12

1

3

High-throughput

0.508

High

1157361

STAC3
SH3 and cysteine-rich domain-containing protein 3

1

2

High-throughput

0.508

High

1157390

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

2

High-throughput

0.508

High

1157407

ZN451
E3 SUMO-protein ligase ZNF451

1

1

High-throughput

0.508

High

174967

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

917449

H4
Histone H4

1

6

Small-scale

0.501

High

934886

H31
Histone H3.1

1

20

Small-scale

0.501

High

609917

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

Small-scale

0.500

High

259452

NIPS2
Protein NipSnap homolog 2

1

1

High-throughput

0.489

High

312936

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.486

High

325967

GNA14
Guanine nucleotide-binding protein subunit alpha-14

1

0

High-throughput

0.486

High

1057888

DIP2A
Disco-interacting protein 2 homolog A

1

0

High-throughput

0.486

High

1075323

TAF1A
TATA box-binding protein-associated factor RNA polymerase I subunit A

1

0

High-throughput

0.486

High

1157324

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

0

High-throughput

0.486

High

1157325

LIAT1
Protein LIAT1

1

0

High-throughput

0.486

High

1157336

CENPL
Centromere protein L

1

0

High-throughput

0.486

High

1157331

CARM1
Histone-arginine methyltransferase CARM1

1

0

Small-scale

0.479

High

236778

CCNT1
Cyclin-T1

1

3

Small-scale

0.479

High

681488

DNJA1
DnaJ homolog subfamily A member 1

1

2

Small-scale

0.479

High

790679

WASP
Actin nucleation-promoting factor WAS

1

2

Small-scale

0.479

High

824111

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

965541

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

1

Small-scale

0.479

High

986925

SUH
Recombining binding protein suppressor of hairless

1

2

High-throughput

0.479

High

1048861

BOP1
Ribosome biogenesis protein BOP1

1

4

Small-scale

0.479

High

1067736

PDIA6
Protein disulfide-isomerase A6

1

3

High-throughput

0.479

High

1146508

A16L1
Autophagy-related protein 16-1

1

6

Small-scale

0.479

High

1157326

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1157351

HS105
Heat shock protein 105 kDa

1

3

Small-scale

0.479

High

1157379

BRD9
Bromodomain-containing protein 9

1

10

High-throughput

0.479

High

1157384

WDR6
tRNA

1

7

Small-scale

0.479

High

1157396

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1157408

TRAF6
TNF receptor-associated factor 6

1

1

Small-scale

0.479

High

1157387

ANKE1
Ankyrin repeat and EF-hand domain-containing protein 1

1

14

High-throughput

0.464

High

1157397

HMGX4
HMG domain-containing protein 4

1

7

High-throughput

0.464

High

169097

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

Small-scale

0.458

High

178065

NCAM2
Neural cell adhesion molecule 2

1

0

Small-scale

0.458

High

279598

FLOT1
Flotillin-1

1

0

Small-scale

0.458

High

400336

RLA1
Large ribosomal subunit protein P1

1

0

Small-scale

0.458

High

564941

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.458

High

654437

CALX
Calnexin

1

0

Small-scale

0.458

High

875652

MFAP1
Microfibrillar-associated protein 1

1

0

Small-scale

0.458

High

896763

ARP3
Actin-related protein 3

1

0

Small-scale

0.458

High

1064405

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1157350

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1157357

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1157376

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1157381

UCK1
Uridine-cytidine kinase 1

1

0

Small-scale

0.458

High

517313

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.457

High

134087

DDX3X
ATP-dependent RNA helicase DDX3X

1

3

Small-scale

0.445

High

235913

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

Small-scale

0.445

High

442240

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

5

Small-scale

0.445

High

516559

PABP1
Polyadenylate-binding protein 1

1

2

Small-scale

0.445

High

523029

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

Small-scale

0.445

High

541045

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

3

Small-scale

0.445

High

571492

DDX5
Probable ATP-dependent RNA helicase DDX5

1

5

Small-scale

0.445

High

582341

NUCL
Nucleolin

1

2

Small-scale

0.445

High

613492

SFPQ
Splicing factor, proline- and glutamine-rich

1

5

Small-scale

0.445

High

726883

FUS
RNA-binding protein FUS

1

4

Small-scale

0.445

High

967235

EWS
RNA-binding protein EWS

1

2

Small-scale

0.445

High

1030297

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

Small-scale

0.445

High

1031365

PABP4
Polyadenylate-binding protein 4

1

2

Small-scale

0.445

High

1069710

NONO
Non-POU domain-containing octamer-binding protein

1

7

Small-scale

0.445

High

1157349

PSPC1
Paraspeckle component 1

1

7

Small-scale

0.445

High

1157353

TFG
Protein TFG

1

5

Small-scale

0.445

High

1157354

RBP56
TATA-binding protein-associated factor 2N

1

3

Small-scale

0.445

High

1157355

DDX17
Probable ATP-dependent RNA helicase DDX17

1

5

Small-scale

0.445

High

1157356

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

1

Small-scale

0.445

High

1157363

RBM14
RNA-binding protein 14

1

4

Small-scale

0.445

High

1157370

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

7

Small-scale

0.445

High

655398

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

Small-scale

0.426

High

903994

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

Small-scale

0.426

High

1074047

SC23B
Protein transport protein Sec23B

1

0

Small-scale

0.426

High

1077195

U2AFL
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1

1

2

High-throughput

0.407

High

1157378

CAAP1
Caspase activity and apoptosis inhibitor 1

2

0

High-throughput

0.328

High

1086425

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

High-throughput

0.279

Low

1157339

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

1157344

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1157322

RSPO2
R-spondin-2

1

0

High-throughput

0.265

Low

320101

CXL14
C-X-C motif chemokine 14

1

0

Small-scale

0.261

Low

1126321

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

Small-scale

0.249

Low

1157371

TMED9
Transmembrane emp24 domain-containing protein 9

1

0

Small-scale

0.249

Low

483697

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low

484548

GAL3A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024