Protein: PTPRN
Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]

Gene: PTPRN
Organism: Homo sapiens
Interactions: 125
UniProt ID: Q16849

Gene Ontology (top 5):
GO:0000302 - response to reactive oxygen species
GO:0001553 - luteinization
GO:0005634 - nucleus
GO:0005768 - endosome
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1164065

PTPR2
Receptor-type tyrosine-protein phosphatase N2

2

19

High-throughput

0.811

High

1102708

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

17

Small-scale

0.740

High

1164039

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

2

18

Small-scale

0.726

High

949246

MYPR
Myelin proteolipid protein

6

0

High-throughput

0.711

High

1164078

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

11

High-throughput

0.691

High

1164045

TM214
Transmembrane protein 214

3

1

High-throughput

0.667

High

155416

PTPRT
Receptor-type tyrosine-protein phosphatase T

1

19

Small-scale

0.653

High

1164064

SNX19
Sorting nexin-19

2

2

Small-scale

0.631

High

318989

MICA2
[F-actin]-monooxygenase MICAL2

2

7

High-throughput

0.628

High

719716

HLAF
HLA class I histocompatibility antigen, alpha chain F

2

2

High-throughput

0.628

High

1104828

SNTB2
Beta-2-syntrophin

2

14

Small-scale

0.625

High

1164050

FRMD5
FERM domain-containing protein 5

1

7

High-throughput

0.618

High

535122

BIP
Endoplasmic reticulum chaperone BiP

2

8

High-throughput

0.611

High

870719

CXA8
Gap junction alpha-8 protein

2

9

High-throughput

0.606

High

1093512

TRDN
Triadin

2

3

High-throughput

0.606

High

1164058

GP152
Probable G-protein coupled receptor 152

2

15

High-throughput

0.606

High

1131274

GANAB
Neutral alpha-glucosidase AB

2

4

High-throughput

0.584

High

1142283

PDIA6
Protein disulfide-isomerase A6

2

18

High-throughput

0.584

High

1164083

CC134
Coiled-coil domain-containing protein 134

2

0

High-throughput

0.580

High

207708

SGSM2
Small G protein signaling modulator 2

2

5

High-throughput

0.574

High

1164055

MFSD8
Major facilitator superfamily domain-containing protein 8

2

6

High-throughput

0.574

High

1164060

NEUFC
Neuferricin

2

5

High-throughput

0.574

High

986457

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

Small-scale

0.573

High

1164062

MADD
MAP kinase-activating death domain protein

1

6

Small-scale

0.573

High

1164082

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

5

Small-scale

0.573

High

1164071

TMM80
Transmembrane protein 80

2

2

High-throughput

0.553

High

1164086

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

2

1

High-throughput

0.553

High

125018

KCNK1
Potassium channel subfamily K member 1

1

1

High-throughput

0.536

High

161039

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

4

High-throughput

0.536

High

247515

FZD6
Frizzled-6

1

3

High-throughput

0.536

High

276242

SEM7A
Semaphorin-7A

1

1

High-throughput

0.536

High

1164041

HFE
Hereditary hemochromatosis protein

1

5

High-throughput

0.536

High

1164072

KI16B
Kinesin-like protein KIF16B

1

8

High-throughput

0.536

High

1164089

IMPA3
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

1

1

High-throughput

0.536

High

452274

PDIA1
Protein disulfide-isomerase

2

15

High-throughput

0.533

High

566691

PDIA4
Protein disulfide-isomerase A4

2

17

High-throughput

0.533

High

698703

CALX
Calnexin

2

10

High-throughput

0.533

High

1164087

UBQL4
Ubiquilin-4

1

6

High-throughput

0.508

High

269774

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

11

Small-scale

0.501

High

606002

CAN2
Calpain-2 catalytic subunit

1

2

Small-scale

0.501

High

1116990

LAMB3
Laminin subunit beta-3

1

6

High-throughput

0.489

High

1147523

UBE3C
Ubiquitin-protein ligase E3C

1

11

High-throughput

0.489

High

1164043

RETST
All-trans-retinol 13,14-reductase

1

1

High-throughput

0.489

High

1164075

CP2S1
Cytochrome P450 2S1

1

1

High-throughput

0.489

High

1164101

DJC16
DnaJ homolog subfamily C member 16

1

20

High-throughput

0.489

High

1164102

MAN1
Inner nuclear membrane protein Man1

1

3

High-throughput

0.489

High

134045

IPO5
Importin-5

1

10

High-throughput

0.479

High

211796

ZW10
Centromere/kinetochore protein zw10 homolog

1

1

High-throughput

0.479

High

229722

CALU
Calumenin

1

2

High-throughput

0.479

High

251217

RNBP6
Ran-binding protein 6

1

10

High-throughput

0.479

High

251902

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

4

High-throughput

0.479

High

273196

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

13

High-throughput

0.479

High

573495

ENPL
Endoplasmin

1

2

High-throughput

0.479

High

656140

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

High-throughput

0.479

High

697899

CALR
Calreticulin

1

10

High-throughput

0.479

High

717489

PDIA3
Protein disulfide-isomerase A3

1

16

High-throughput

0.479

High

813106

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.479

High

828370

PEX19
Peroxisomal biogenesis factor 19

1

1

High-throughput

0.479

High

934086

XPO2
Exportin-2

1

20

High-throughput

0.479

High

1038873

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

4

High-throughput

0.479

High

1140344

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

1164046

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

1164047

DYM
Dymeclin

1

1

High-throughput

0.479

High

1164057

CIP2A
Protein CIP2A

1

3

High-throughput

0.479

High

1164063

S39A7
Zinc transporter SLC39A7

1

12

High-throughput

0.479

High

1164066

TNPO1
Transportin-1

1

18

High-throughput

0.479

High

1164068

ASTRA
Protein Aster-A

1

3

High-throughput

0.479

High

1164069

SAAL1
Protein SAAL1

1

5

High-throughput

0.479

High

1164074

XPO6
Exportin-6

1

1

High-throughput

0.479

High

1164080

XPO4
Exportin-4

1

12

High-throughput

0.479

High

1164081

TTYH3
Protein tweety homolog 3

1

1

High-throughput

0.479

High

1164085

XPO5
Exportin-5

1

20

High-throughput

0.479

High

1164093

ATX10
Ataxin-10

1

2

High-throughput

0.479

High

1164094

NCDN
Neurochondrin

1

1

High-throughput

0.479

High

1164096

DJB11
DnaJ homolog subfamily B member 11

1

2

High-throughput

0.479

High

1164079

TMM43
Transmembrane protein 43

1

0

High-throughput

0.458

High

1164090

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

0

High-throughput

0.458

High

1164095

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.458

High

380547

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

5

High-throughput

0.445

High

1119152

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

12

High-throughput

0.445

High

1164052

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

2

High-throughput

0.445

High

220918

XPOT
Exportin-T

1

19

High-throughput

0.437

High

258290

TRI13
E3 ubiquitin-protein ligase TRIM13

1

4

High-throughput

0.437

High

317850

LTN1
E3 ubiquitin-protein ligase listerin

1

2

High-throughput

0.437

High

360426

COX2
Cytochrome c oxidase subunit 2

1

1

High-throughput

0.437

High

418164

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.437

High

571446

GLU2B
Glucosidase 2 subunit beta

1

3

High-throughput

0.437

High

963074

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

4

High-throughput

0.437

High

1164042

TGO1
Transport and Golgi organization protein 1 homolog

1

7

High-throughput

0.437

High

1164044

RINT1
RAD50-interacting protein 1

1

2

High-throughput

0.437

High

1164048

MON2
Protein MON2 homolog

1

4

High-throughput

0.437

High

1164049

HEAT3
HEAT repeat-containing protein 3

1

1

High-throughput

0.437

High

1164051

DAAF5
Dynein axonemal assembly factor 5

1

1

High-throughput

0.437

High

1164053

GT251
Procollagen galactosyltransferase 1

1

4

High-throughput

0.437

High

1164054

TXND5
Thioredoxin domain-containing protein 5

1

18

High-throughput

0.437

High

1164056

TBC15
TBC1 domain family member 15

1

5

High-throughput

0.437

High

1164059

PO210
Nuclear pore membrane glycoprotein 210

1

1

High-throughput

0.437

High

1164077

ERP44
Endoplasmic reticulum resident protein 44

1

18

High-throughput

0.437

High

1164084

S61A2
Protein transport protein Sec61 subunit alpha isoform 2

1

4

High-throughput

0.437

High

1164091

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

3

High-throughput

0.437

High

1164098

CS025
UPF0449 protein C19orf25

1

2

High-throughput

0.437

High

1164103

HYOU1
Hypoxia up-regulated protein 1

1

9

High-throughput

0.437

High

1164104

TNPO3
Transportin-3

1

20

High-throughput

0.437

High

1164105

5MP1
eIF5-mimic protein 1

1

2

High-throughput

0.437

High

222277

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

351683

SG1D1
Secretoglobin family 1D member 1

1

1

High-throughput

0.407

High

976808

LCN6
Epididymal-specific lipocalin-6

1

1

High-throughput

0.407

High

1164100

FBX2
F-box only protein 2

1

11

High-throughput

0.407

High

1094299

PAFA
Platelet-activating factor acetylhydrolase

3

0

High-throughput

0.345

High

1164070

MITOK
Mitochondrial potassium channel

2

0

High-throughput

0.328

High

1164076

ADPGK
ADP-dependent glucokinase

2

0

High-throughput

0.328

High

184991

SPTC2
Serine palmitoyltransferase 2

2

0

High-throughput

0.318

High

636221

MAL
Myelin and lymphocyte protein

1

0

High-throughput

0.299

High

590915

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.279

Low

1164040

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

0

High-throughput

0.279

Low

1164067

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

0

High-throughput

0.279

Low

1164073

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

1

0

High-throughput

0.279

Low

1164099

METRN
Meteorin

1

0

High-throughput

0.279

Low

1164097

CLN8
Protein CLN8

1

0

Small-scale

0.251

Low

228822

SCO2
Protein SCO2 homolog, mitochondrial

1

0

High-throughput

0.249

Low

1105465

OS9
Protein OS-9

1

0

High-throughput

0.249

Low

1164088

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.249

Low

1164092

CNIH4
Protein cornichon homolog 4

1

0

High-throughput

0.249

Low

1164061

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025