Protein: DCTN3
Dynactin subunit 3 (Dynactin complex subunit 22 kDa subunit) (p22)

Gene: DCTN3
Organism: Homo sapiens
Interactions: 136
UniProt ID: O75935

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000776 - kinetochore
GO:0005198 - structural molecule activity
GO:0005730 - nucleolus
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

298168

DCTN2
Dynactin subunit 2

11

0

High-throughput

0.927

High

298170

DCTN1
Dynactin subunit 1

5

1

High-throughput

0.720

High

298148

CAZA2
F-actin-capping protein subunit alpha-2

5

1

High-throughput

0.716

High

298147

ACTY
Beta-centractin

3

3

High-throughput

0.667

High

298155

ACTZ
Alpha-centractin

3

3

High-throughput

0.650

High

298164

GPS2
G protein pathway suppressor 2

3

0

High-throughput

0.638

High

133329

DCTN6
Dynactin subunit 6

3

0

High-throughput

0.634

High

298149

CAPZB
F-actin-capping protein subunit beta

3

0

High-throughput

0.634

High

298239

MS18A
Protein Mis18-alpha

3

0

High-throughput

0.634

High

298196

AROS
Active regulator of SIRT1

2

0

High-throughput

0.602

High

298221

DCTN5
Dynactin subunit 5

2

1

High-throughput

0.601

High

298152

ATX1
Ataxin-1

2

0

High-throughput

0.593

High

298131

KLHL2
Kelch-like protein 2

2

0

High-throughput

0.585

High

298166

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

2

0

High-throughput

0.585

High

298178

CSPP1
Centrosome and spindle pole-associated protein 1

2

0

High-throughput

0.585

High

298129

KRT34
Keratin, type I cuticular Ha4

2

0

High-throughput

0.580

High

298247

POMP
Proteasome maturation protein

2

0

High-throughput

0.576

High

298184

ACTBL
Beta-actin-like protein 2

2

2

High-throughput

0.574

High

290279

KS6A4
Ribosomal protein S6 kinase alpha-4

1

1

High-throughput

0.536

High

298151

CAZA1
F-actin-capping protein subunit alpha-1

1

1

High-throughput

0.536

High

298156

ACTA
Actin, aortic smooth muscle

1

2

High-throughput

0.536

High

298158

ACTG
Actin, cytoplasmic 2

1

2

High-throughput

0.536

High

298172

KS6A2
Ribosomal protein S6 kinase alpha-2

1

1

High-throughput

0.536

High

298212

NACC2
Nucleus accumbens-associated protein 2

1

1

High-throughput

0.536

High

217236

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.513

High

298128

RAD17
Cell cycle checkpoint protein RAD17

1

0

High-throughput

0.513

High

298130

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

0

High-throughput

0.513

High

298134

SNP29
Synaptosomal-associated protein 29

1

0

High-throughput

0.513

High

298138

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

298141

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

298144

CLIP1
CAP-Gly domain-containing linker protein 1

1

0

High-throughput

0.513

High

298157

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.513

High

298161

TF65
Transcription factor p65

1

0

High-throughput

0.513

High

298167

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

0

High-throughput

0.513

High

298169

RIN1
Ras and Rab interactor 1

1

0

High-throughput

0.513

High

298171

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

0

High-throughput

0.513

High

298173

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.513

High

298176

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

298182

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

0

High-throughput

0.513

High

298193

SEP14
Septin-14

1

0

High-throughput

0.513

High

298195

CLAP1
CLIP-associating protein 1

1

0

High-throughput

0.513

High

298204

NEDD1
Protein NEDD1

1

0

High-throughput

0.513

High

298207

CTF18
Chromosome transmission fidelity protein 18 homolog

1

0

High-throughput

0.513

High

298210

SYMPK
Symplekin

1

0

High-throughput

0.513

High

298222

THUM3
tRNA

1

0

High-throughput

0.513

High

298226

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

298229

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

0

High-throughput

0.513

High

298232

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

0

High-throughput

0.513

High

298243

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

298246

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

0

High-throughput

0.513

High

298249

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.513

High

298250

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.513

High

167206

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

298150

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.486

High

169861

AURKA
Aurora kinase A

1

1

High-throughput

0.479

High

298200

NIN
Ninein

1

1

High-throughput

0.479

High

298217

SCLT1
Sodium channel and clathrin linker 1

1

1

High-throughput

0.479

High

298248

NINL
Ninein-like protein

1

1

High-throughput

0.479

High

128681

MEN1
Menin

1

0

High-throughput

0.458

High

168481

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

0

High-throughput

0.458

High

298153

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

298154

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

298165

NMI
N-myc-interactor

1

0

High-throughput

0.458

High

298191

LMTK1
Serine/threonine-protein kinase LMTK1

1

0

High-throughput

0.458

High

298209

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

298242

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

298245

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.458

High

298214

AURKB
Aurora kinase B

1

1

High-throughput

0.445

High

298225

TRI55
Tripartite motif-containing protein 55

1

1

High-throughput

0.439

High

227283

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.437

High

298192

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

298236

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

High-throughput

0.437

High

298132

PSMG1
Proteasome assembly chaperone 1

1

0

High-throughput

0.426

High

298140

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.426

High

298162

RHG01
Rho GTPase-activating protein 1

1

0

High-throughput

0.426

High

298189

TWF2
Twinfilin-2

1

0

High-throughput

0.426

High

298198

ASPM
Abnormal spindle-like microcephaly-associated protein

1

0

Small-scale

0.426

High

298208

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

0

High-throughput

0.426

High

298211

PSMG2
Proteasome assembly chaperone 2

1

0

High-throughput

0.426

High

298216

CI072
Guanine nucleotide exchange factor C9orf72

1

0

Small-scale

0.426

High

94300

D6R9G5
Kelch like family member 2

1

1

High-throughput

0.407

High

298136

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

2

0

High-throughput

0.328

High

298227

PDGFD
Platelet-derived growth factor D

2

0

High-throughput

0.328

High

298228

DB127
Beta-defensin 127

2

0

High-throughput

0.328

High

298142

C4BPB
C4b-binding protein beta chain

2

0

High-throughput

0.318

High

298233

CAH10
Carbonic anhydrase-related protein 10

2

0

High-throughput

0.318

High

298235

THAP1
THAP domain-containing protein 1

2

0

High-throughput

0.318

High

63161

VP37C
Vacuolar protein sorting-associated protein 37C

2

0

High-throughput

0.316

High

298159

PITX1
Pituitary homeobox 1

2

0

High-throughput

0.316

High

298175

PCH2
Pachytene checkpoint protein 2 homolog

2

0

High-throughput

0.316

High

298194

NUP54
Nucleoporin p54

2

0

High-throughput

0.316

High

298202

USBP1
Harmonin-binding protein USHBP1

2

0

High-throughput

0.316

High

66915

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.279

Low

298133

CXL14
C-X-C motif chemokine 14

1

0

High-throughput

0.279

Low

298135

CYTS
Cystatin-S

1

0

High-throughput

0.279

Low

298137

TSP1
Thrombospondin-1

1

0

High-throughput

0.279

Low

298160

FOXK2
Forkhead box protein K2

1

0

High-throughput

0.279

Low

298163

COASY
Bifunctional coenzyme A synthase

1

0

High-throughput

0.279

Low

298174

MED22
Mediator of RNA polymerase II transcription subunit 22

1

0

High-throughput

0.279

Low

298179

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

298180

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.279

Low

298181

INAVA
Innate immunity activator protein

1

0

High-throughput

0.279

Low

298185

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.279

Low

298187

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.279

Low

298188

N42L1
NEDD4-binding protein 2-like 1

1

0

High-throughput

0.279

Low

298190

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.279

Low

298197

I2BP1
Interferon regulatory factor 2-binding protein 1

1

0

High-throughput

0.279

Low

298201

LRA25
Leucine repeat adapter protein 25

1

0

High-throughput

0.279

Low

298203

PAF1
RNA polymerase II-associated factor 1 homolog

1

0

High-throughput

0.279

Low

298205

CC4L
C-C motif chemokine 4-like

1

0

High-throughput

0.279

Low

298206

ZN398
Zinc finger protein 398

1

0

High-throughput

0.279

Low

298213

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.279

Low

298215

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.279

Low

298218

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

0

High-throughput

0.279

Low

298220

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.279

Low

298224

SELO
Protein adenylyltransferase SelO, mitochondrial

1

0

High-throughput

0.279

Low

298231

RIC8A
Chaperone Ric-8A

1

0

High-throughput

0.279

Low

298234

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.279

Low

298223

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.268

Low

298183

DUS28
Dual specificity phosphatase 28

1

0

High-throughput

0.249

Low

298186

PHF19
PHD finger protein 19

1

0

High-throughput

0.249

Low

298230

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.249

Low

298237

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.249

Low

298241

RN181
E3 ubiquitin-protein ligase RNF181

1

0

High-throughput

0.249

Low

298244

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.249

Low

298145

PBX2
Pre-B-cell leukemia transcription factor 2

1

0

Small-scale

0.238

Low

254686

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

261022

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

298139

ANFB
Natriuretic peptides B

1

0

High-throughput

0.232

Low

298143

ACKR3
Atypical chemokine receptor 3

1

0

High-throughput

0.232

Low

298146

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

0

High-throughput

0.232

Low

298177

F187B
Protein FAM187B

1

0

High-throughput

0.232

Low

298199

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

298219

SNAG
Gamma-soluble NSF attachment protein

1

0

High-throughput

0.232

Low

298238

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.232

Low

298240

LMCD1
LIM and cysteine-rich domains protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025