Protein: HPSE2
Inactive heparanase-2 (Hpa2)

Gene: HPSE2
Organism: Homo sapiens
Interactions: 23
UniProt ID: Q8WWQ2

Gene Ontology (top 5):
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0008283 - cell population proliferation
GO:0008284 - positive regulation of cell population proliferation
GO:0030198 - extracellular matrix organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

535344

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

1294364

FRAS1
Extracellular matrix organizing protein FRAS1

1

1

High-throughput

0.536

High

1359736

AGRV1
Adhesion G-protein coupled receptor V1

1

1

High-throughput

0.536

High

1055335

APLP2
Amyloid beta precursor like protein 2

1

0

High-throughput

0.513

High

220511

RNF13
E3 ubiquitin-protein ligase RNF13

1

1

High-throughput

0.489

High

231744

PEX1
Peroxisomal ATPase PEX1

1

1

High-throughput

0.489

High

274206

ANR17
Ankyrin repeat domain-containing protein 17

1

1

High-throughput

0.489

High

1112258

PEX6
Peroxisomal ATPase PEX6

1

1

High-throughput

0.489

High

1311353

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

1

High-throughput

0.489

High

1358807

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

1

High-throughput

0.489

High

1359737

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.470

High

951782

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

451550

CENPB
Major centromere autoantigen B

1

0

High-throughput

0.279

Low

1150672

TRBP2
RISC-loading complex subunit TARBP2

1

0

High-throughput

0.279

Low

1359738

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.279

Low

1359739

ZN496
Zinc finger protein 496

1

0

High-throughput

0.279

Low

1359740

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.279

Low

1359741

IFT22
Intraflagellar transport protein 22 homolog

1

0

High-throughput

0.279

Low

1359743

DICER
Endoribonuclease Dicer

1

0

High-throughput

0.279

Low

1359744

DCAF1
DDB1- and CUL4-associated factor 1

1

0

High-throughput

0.279

Low

1359745

T10B
Mitochondrial import inner membrane translocase subunit Tim10 B

1

0

High-throughput

0.279

Low

1359742

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

1211077

PR15B
Protein phosphatase 1 regulatory subunit 15B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025