Protein: FURIN
Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE)

Gene: FURIN
Organism: Homo sapiens
Interactions: 228
UniProt ID: P09958

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001825 - blastocyst formation
GO:0002020 - protease binding
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0004175 - endopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

456806

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

2

High-throughput

0.691

High

456789

FURIN
Furin

1

13

High-throughput

0.665

High

456827

MMP14
Matrix metalloproteinase-14

3

2

Small-scale

0.650

High

456946

ISK5
Serine protease inhibitor Kazal-type 5

1

1

Small-scale

0.647

High

456903

PXYP1
2-phosphoxylose phosphatase 1

3

0

High-throughput

0.638

High

397631

IPSP
Plasma serine protease inhibitor

2

2

High-throughput

0.628

High

456837

FCGRN
IgG receptor FcRn large subunit p51

2

4

High-throughput

0.628

High

456965

FND3A
Fibronectin type-III domain-containing protein 3A

1

2

High-throughput

0.618

High

155750

GDF8
Growth/differentiation factor 8

2

3

Small-scale

0.602

High

456822

5HT3A
5-hydroxytryptamine receptor 3A

2

0

High-throughput

0.602

High

456835

SNAA
Alpha-soluble NSF attachment protein

1

0

Small-scale

0.549

High

421251

GDN
Glia-derived nexin

1

3

High-throughput

0.536

High

456805

LSHR
Lutropin-choriogonadotropic hormone receptor

1

1

High-throughput

0.536

High

456814

BMR1A
Bone morphogenetic protein receptor type-1A

1

1

High-throughput

0.536

High

456855

ATP7A
Copper-transporting ATPase 1

1

1

High-throughput

0.536

High

456878

PRSS8
Prostasin

1

1

High-throughput

0.536

High

456888

BRID5
BRICHOS domain-containing protein 5

1

1

High-throughput

0.536

High

456892

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.536

High

456910

T106A
Transmembrane protein 106A

1

1

High-throughput

0.536

High

456913

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

4

High-throughput

0.536

High

456922

NEUS
Neuroserpin

1

3

High-throughput

0.536

High

456941

RISC
Retinoid-inducible serine carboxypeptidase

1

1

High-throughput

0.536

High

456973

ORNT1
Mitochondrial ornithine transporter 1

1

5

High-throughput

0.536

High

123467

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.515

High

385963

P53
Cellular tumor antigen p53

1

1

High-throughput

0.515

High

456799

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

1

High-throughput

0.515

High

456820

VDAC2
Voltage-dependent anion-selective channel protein 2

1

1

High-throughput

0.515

High

456829

SERPH
Serpin H1

1

5

High-throughput

0.515

High

456839

RAB10
Ras-related protein Rab-10

1

2

High-throughput

0.515

High

456853

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

1

High-throughput

0.515

High

456936

MMP28
Matrix metalloproteinase-28

1

2

Small-scale

0.515

High

456956

DJB11
DnaJ homolog subfamily B member 11

1

4

High-throughput

0.515

High

456958

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

3

High-throughput

0.515

High

48239

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.513

High

60282

POTEF
POTE ankyrin domain family member F

1

0

High-throughput

0.513

High

301172

RHBT3
Rho-related BTB domain-containing protein 3

1

0

High-throughput

0.513

High

456823

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.513

High

456848

SMAD3
Mothers against decapentaplegic homolog 3

1

0

High-throughput

0.513

High

456857

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.513

High

456898

NRSN1
Neurensin-1

1

0

High-throughput

0.513

High

456899

WDFY3
WD repeat and FYVE domain-containing protein 3

1

0

High-throughput

0.513

High

456906

ELYS
Protein ELYS

1

0

High-throughput

0.513

High

456907

LGAT1
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

1

0

High-throughput

0.513

High

456919

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.513

High

456942

S38AA
Solute carrier family 38 member 10

1

0

High-throughput

0.513

High

456961

KDIS
Kinase D-interacting substrate of 220 kDa

1

0

High-throughput

0.513

High

456964

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

0

High-throughput

0.513

High

456967

MAN1
Inner nuclear membrane protein Man1

1

0

High-throughput

0.513

High

456828

SPB8
Serpin B8

1

3

Small-scale

0.501

High

456856

RON
Macrophage-stimulating protein receptor

1

3

Small-scale

0.501

High

456912

AP2M1
AP-2 complex subunit mu

1

1

Small-scale

0.501

High

280189

CBPD
Carboxypeptidase D

1

0

High-throughput

0.493

High

299824

ERLN2
Erlin-2

1

0

High-throughput

0.493

High

456825

K2C6C
Keratin, type II cytoskeletal 6C

1

0

High-throughput

0.493

High

456832

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.493

High

456881

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.493

High

393987

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

456880

CL12B
C-type lectin domain family 12 member B

1

2

High-throughput

0.489

High

456947

HELLS
Lymphoid-specific helicase

1

1

High-throughput

0.489

High

456954

RAI14
Ankycorbin

1

2

High-throughput

0.489

High

309772

MRP6
ATP-binding cassette sub-family C member 6

1

1

High-throughput

0.481

High

117565

MYO1C
Unconventional myosin-Ic

1

2

High-throughput

0.479

High

204959

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

211469

ACTN4
Alpha-actinin-4

1

2

High-throughput

0.479

High

214478

MYO1B
Unconventional myosin-Ib

1

2

High-throughput

0.479

High

297275

MYO1D
Unconventional myosin-Id

1

2

High-throughput

0.479

High

302093

AP2A2
AP-2 complex subunit alpha-2

1

2

High-throughput

0.479

High

302244

SC31A
Protein transport protein Sec31A

1

3

High-throughput

0.479

High

315510

SC24A
Protein transport protein Sec24A

1

3

High-throughput

0.479

High

321469

AP2A1
AP-2 complex subunit alpha-1

1

2

High-throughput

0.479

High

382274

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

3

High-throughput

0.479

High

391312

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

2

High-throughput

0.479

High

397236

ADT2
ADP/ATP translocase 2

1

3

High-throughput

0.479

High

418854

TPM3
Tropomyosin alpha-3 chain

1

3

High-throughput

0.479

High

444651

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

2

High-throughput

0.479

High

456790

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

3

High-throughput

0.479

High

456792

SPTB1
Spectrin beta chain, erythrocytic

1

3

High-throughput

0.479

High

456793

ADT3
ADP/ATP translocase 3

1

3

High-throughput

0.479

High

456794

ACTN1
Alpha-actinin-1

1

2

High-throughput

0.479

High

456795

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

456796

XRCC5
X-ray repair cross-complementing protein 5

1

1

High-throughput

0.479

High

456798

ENPL
Endoplasmin

1

5

High-throughput

0.479

High

456800

ARF4
ADP-ribosylation factor 4

1

1

High-throughput

0.479

High

456803

RAB6A
Ras-related protein Rab-6A

1

2

High-throughput

0.479

High

456807

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

456813

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.479

High

456817

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

1

High-throughput

0.479

High

456818

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

1

High-throughput

0.479

High

456830

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.479

High

456831

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.479

High

456838

RAB8A
Ras-related protein Rab-8A

1

2

High-throughput

0.479

High

456840

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

456843

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

456844

AP2B1
AP-2 complex subunit beta

1

2

High-throughput

0.479

High

456845

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

2

High-throughput

0.479

High

456846

TPM4
Tropomyosin alpha-4 chain

1

3

High-throughput

0.479

High

456850

S25A3
Solute carrier family 25 member 3

1

4

High-throughput

0.479

High

456851

DHSO
Sorbitol dehydrogenase

1

1

High-throughput

0.479

High

456852

LAT1
Large neutral amino acids transporter small subunit 1

1

1

High-throughput

0.479

High

456854

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

6

High-throughput

0.479

High

456864

GOGA4
Golgin subfamily A member 4

1

1

High-throughput

0.479

High

456865

CUL3
Cullin-3

1

2

High-throughput

0.479

High

456866

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

4

High-throughput

0.479

High

456867

SAFB2
Scaffold attachment factor B2

1

1

High-throughput

0.479

High

456868

GOGB1
Golgin subfamily B member 1

1

1

High-throughput

0.479

High

456869

RB39A
Ras-related protein Rab-39A

1

2

High-throughput

0.479

High

456873

RCN1
Reticulocalbin-1

1

1

High-throughput

0.479

High

456875

SC23A
Protein transport protein Sec23A

1

3

High-throughput

0.479

High

456876

SC23B
Protein transport protein Sec23B

1

3

High-throughput

0.479

High

456877

TRIPB
Thyroid receptor-interacting protein 11

1

2

High-throughput

0.479

High

456895

GCC2
GRIP and coiled-coil domain-containing protein 2

1

2

High-throughput

0.479

High

456896

MIRO1
Mitochondrial Rho GTPase 1

1

3

High-throughput

0.479

High

456900

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

2

High-throughput

0.479

High

456905

SMAP2
Stromal membrane-associated protein 2

1

2

High-throughput

0.479

High

456914

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

High-throughput

0.479

High

456924

AIF1L
Allograft inflammatory factor 1-like

1

1

High-throughput

0.479

High

456927

TBB6
Tubulin beta-6 chain

1

2

High-throughput

0.479

High

456930

AP1M1
AP-1 complex subunit mu-1

1

1

High-throughput

0.479

High

456933

LSG1
Large subunit GTPase 1 homolog

1

1

High-throughput

0.479

High

456935

RAB1B
Ras-related protein Rab-1B

1

1

High-throughput

0.479

High

456945

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

2

High-throughput

0.479

High

456951

DDX56
Probable ATP-dependent RNA helicase DDX56

1

1

High-throughput

0.479

High

456874

SAFB1
Scaffold attachment factor B1

1

1

High-throughput

0.470

High

456893

YTHD3
YTH domain-containing family protein 3

1

3

High-throughput

0.470

High

456971

YTHD2
YTH domain-containing family protein 2

1

3

High-throughput

0.470

High

127168

IPO5
Importin-5

1

0

High-throughput

0.458

High

169019

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

High-throughput

0.458

High

215095

LANC1
Glutathione S-transferase LANCL1

1

0

High-throughput

0.458

High

316558

ACSL3
Fatty acid CoA ligase Acsl3

1

0

High-throughput

0.458

High

363476

FETUA
Alpha-2-HS-glycoprotein

1

0

High-throughput

0.458

High

390029

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

390670

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

392992

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

398623

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

0

High-throughput

0.458

High

456791

CLUS
Clusterin

1

0

High-throughput

0.458

High

456797

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.458

High

456802

HXK1
Hexokinase-1

1

0

High-throughput

0.458

High

456804

MSH3
DNA mismatch repair protein Msh3

1

0

High-throughput

0.458

High

456808

PRDX6
Peroxiredoxin-6

1

0

High-throughput

0.458

High

456810

KCY
UMP-CMP kinase

1

0

High-throughput

0.458

High

456811

BASI
Basigin

1

0

High-throughput

0.458

High

456815

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.458

High

456819

NAMPT
Nicotinamide phosphoribosyltransferase

1

0

High-throughput

0.458

High

456834

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.458

High

456836

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.458

High

456841

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

0

High-throughput

0.458

High

456842

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.458

High

456847

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

High-throughput

0.458

High

456858

GOGA3
Golgin subfamily A member 3

1

0

High-throughput

0.458

High

456859

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.458

High

456870

SYK
Lysine--tRNA ligase

1

0

High-throughput

0.458

High

456871

PON2
Serum paraoxonase/arylesterase 2

1

0

High-throughput

0.458

High

456872

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.458

High

456879

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

456882

ZN326
DBIRD complex subunit ZNF326

1

0

High-throughput

0.458

High

456884

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.458

High

456891

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

0

High-throughput

0.458

High

456901

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

456902

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

456911

SYAP1
Synapse-associated protein 1

1

0

High-throughput

0.458

High

456915

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.458

High

456920

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.458

High

456925

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.458

High

456926

ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase

1

0

High-throughput

0.458

High

456934

DDX47
Probable ATP-dependent RNA helicase DDX47

1

0

High-throughput

0.458

High

456937

SPNS1
Protein spinster homolog 1

1

0

High-throughput

0.458

High

456938

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.458

High

456939

GORS2
Golgi reassembly-stacking protein 2

1

0

High-throughput

0.458

High

456943

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

0

High-throughput

0.458

High

456944

TM9S3
Transmembrane 9 superfamily member 3

1

0

High-throughput

0.458

High

456949

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

456950

NSMA3
Sphingomyelin phosphodiesterase 4

1

0

High-throughput

0.458

High

456953

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.458

High

456960

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

0

High-throughput

0.458

High

456962

MYO6
Unconventional myosin-VI

1

0

High-throughput

0.458

High

456970

HYOU1
Hypoxia up-regulated protein 1

1

0

High-throughput

0.458

High

276991

STAM2
Signal transducing adapter molecule 2

1

4

High-throughput

0.437

High

315635

SC24B
Protein transport protein Sec24B

1

3

High-throughput

0.437

High

451178

TPM1
Tropomyosin alpha-1 chain

1

3

High-throughput

0.437

High

456812

DEK
Protein DEK

1

1

High-throughput

0.437

High

456816

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

2

High-throughput

0.437

High

456824

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.437

High

456861

CAF1B
Chromatin assembly factor 1 subunit B

1

2

High-throughput

0.437

High

456883

RABL3
Rab-like protein 3

1

4

High-throughput

0.437

High

456894

PABP2
Polyadenylate-binding protein 2

1

1

High-throughput

0.437

High

456908

TFG
Protein TFG

1

2

High-throughput

0.437

High

456909

STAM1
Signal transducing adapter molecule 1

1

3

High-throughput

0.437

High

456918

RBM14
RNA-binding protein 14

1

1

High-throughput

0.437

High

456928

RBM4
RNA-binding protein 4

1

1

High-throughput

0.437

High

456932

YTHD1
YTH domain-containing family protein 1

1

2

High-throughput

0.437

High

456940

WDR41
WD repeat-containing protein 41

1

1

High-throughput

0.437

High

456963

SNX6
Sorting nexin-6

1

1

High-throughput

0.437

High

309939

ATE1
Arginyl-tRNA--protein transferase 1

2

0

High-throughput

0.324

High

456890

MPRIP
Myosin phosphatase Rho-interacting protein

1

0

High-throughput

0.279

Low

456923

CDC6
Cell division control protein 6 homolog

1

0

High-throughput

0.279

Low

456968

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

High-throughput

0.279

Low

456889

PACS1
Phosphofurin acidic cluster sorting protein 1

1

0

Small-scale

0.275

Low

456860

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.269

Low

130413

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.249

Low

268379

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.249

Low

440307

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.249

Low

456801

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.249

Low

456809

ATPD
ATP synthase subunit delta, mitochondrial

1

0

High-throughput

0.249

Low

456821

CBX5
Chromobox protein homolog 5

1

0

High-throughput

0.249

Low

456826

DNLI3
DNA ligase 3

1

0

High-throughput

0.249

Low

456833

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

456849

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.249

Low

456862

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

0

High-throughput

0.249

Low

456863

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.249

Low

456886

RM14
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.249

Low

456887

SFXN4
Sideroflexin-4

1

0

High-throughput

0.249

Low

456897

M21D2
Nucleotidyltransferase MB21D2

1

0

High-throughput

0.249

Low

456904

SMCR8
Guanine nucleotide exchange protein SMCR8

1

0

High-throughput

0.249

Low

456916

ZFR
Zinc finger RNA-binding protein

1

0

High-throughput

0.249

Low

456917

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

456921

RBM15
RNA-binding protein 15

1

0

High-throughput

0.249

Low

456929

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.249

Low

456931

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.249

Low

456948

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.249

Low

456952

TMOD3
Tropomodulin-3

1

0

High-throughput

0.249

Low

456955

SAE1
SUMO-activating enzyme subunit 1

1

0

High-throughput

0.249

Low

456957

SAE2
SUMO-activating enzyme subunit 2

1

0

High-throughput

0.249

Low

456959

MRT4
mRNA turnover protein 4 homolog

1

0

High-throughput

0.249

Low

456966

TPPC8
Trafficking protein particle complex subunit 8

1

0

High-throughput

0.249

Low

456969

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.249

Low

456972

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

456885

PRAM5
PRAME family member 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024