Protein: YKK0
Probable intramembrane protease YKL100C (EC 3.4.23.-)

Gene: YKK0, YKL100C
Organism: Saccharomyces cerevisiae S288C
Interactions: 62
UniProt ID: P34248

Gene Ontology (top 5):
GO:0006465 - signal peptide processing
GO:0009267 - cellular response to starvation
GO:0033619 - membrane protein proteolysis
GO:0042500 - aspartic endopeptidase activity, intramembrane cleaving
GO:0051603 - proteolysis involved in protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

526334

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.552

High

544375

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.504

High

758451

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.504

High

510363

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.437

High

554332

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

1

High-throughput

0.437

High

554415

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

1

High-throughput

0.437

High

577090

SEC63
Protein translocation protein SEC63

1

1

High-throughput

0.437

High

672789

ELO2
Fatty acid elongase 2

1

2

High-throughput

0.437

High

679547

CDC48
Cell division control protein 48

1

1

High-throughput

0.437

High

726074

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

2

High-throughput

0.437

High

745406

ZRT1
Zinc-regulated transporter 1

1

6

Small-scale

0.437

High

754673

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

2

High-throughput

0.437

High

758437

YET1
Endoplasmic reticulum transmembrane protein 1

1

2

High-throughput

0.437

High

758438

MCD4
GPI ethanolamine phosphate transferase 1

1

4

High-throughput

0.437

High

758439

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

758446

ERP2
Protein ERP2

1

7

High-throughput

0.437

High

758447

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

6

High-throughput

0.437

High

758452

ELO3
Fatty acid elongase 3

1

2

High-throughput

0.437

High

758453

GPI7
GPI ethanolamine phosphate transferase 2

1

4

High-throughput

0.437

High

758457

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

2

High-throughput

0.437

High

758460

HLJ1
Protein HLJ1

1

1

High-throughput

0.437

High

758468

ERP1
Protein ERP1

1

5

High-throughput

0.437

High

758470

YET3
Endoplasmic reticulum transmembrane protein 3

1

2

High-throughput

0.437

High

758471

ERP4
Protein ERP4

1

8

High-throughput

0.437

High

758472

DFM1
DER1-like family member protein 1

1

2

Small-scale

0.437

High

675883

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

486120

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.407

High

523537

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.407

High

741299

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.407

High

742817

HSP79
Heat shock protein homolog SSE2

1

3

High-throughput

0.407

High

758448

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.407

High

758455

DJP1
DnaJ-like protein 1

1

1

High-throughput

0.407

High

758450

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.269

Low

758459

ALDH2
Aldehyde dehydrogenase [NAD(P)+] 1

1

0

High-throughput

0.269

Low

636297

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.249

Low

645238

GAS1
1,3-beta-glucanosyltransferase GAS1

1

0

High-throughput

0.249

Low

754609

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

0

High-throughput

0.249

Low

758440

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

758441

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.249

Low

758443

NSG1
Protein NSG1

1

0

High-throughput

0.249

Low

758444

STT3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

1

0

High-throughput

0.249

Low

758445

PO152
Nucleoporin POM152

1

0

High-throughput

0.249

Low

758454

SNL1
HSP70 co-chaperone SNL1

1

0

High-throughput

0.249

Low

758456

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.249

Low

758461

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.249

Low

758463

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

0

High-throughput

0.249

Low

758466

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

0

High-throughput

0.249

Low

758467

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.249

Low

758469

GPI11
Glycosylphosphatidylinositol anchor biosynthesis protein 11

1

0

High-throughput

0.249

Low

358180

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.232

Low

382009

H4
Histone H4

1

0

High-throughput

0.232

Low

392515

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.232

Low

394426

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

427213

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

661606

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.232

Low

684678

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.232

Low

758442

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.232

Low

758449

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.232

Low

758458

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

758462

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.232

Low

758464

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low

758465

ACT
Actin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025