Protein: SLT2
Mitogen-activated protein kinase SLT2/MPK1 (MAP kinase MPK1) (EC 2.7.11.24)

Gene: SLT2
Organism: Saccharomyces cerevisiae S288C
Interactions: 243
UniProt ID: Q00772

Gene Ontology (top 5):
GO:0000196 - cell wall integrity MAPK cascade
GO:0000425 - pexophagy
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

691208

MKK1
MAP kinase kinase MKK1/SSP32

10

20

Small-scale

0.977

High

750799

MSG5
Tyrosine-protein phosphatase MSG5

8

20

Small-scale

0.976

High

691238

MKK2
MAP kinase kinase MKK2/SSP33

7

20

Small-scale

0.970

High

774392

SDP1
Dual-specificity protein phosphatase SDP1

6

20

Small-scale

0.957

High

366740

HSP82
ATP-dependent molecular chaperone HSP82

6

20

Small-scale

0.949

High

961900

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

5

20

Small-scale

0.929

High

628887

SWI4
Regulatory protein SWI4

3

6

Small-scale

0.891

High

457059

SWI6
Regulatory protein SWI6

2

8

Small-scale

0.825

High

767307

PTP3
Tyrosine-protein phosphatase 3

2

20

Small-scale

0.825

High

526290

KIN2
Serine/threonine-protein kinase KIN2

2

3

High-throughput

0.811

High

752269

KIC1
Serine/threonine-protein kinase KIC1

2

20

High-throughput

0.811

High

863044

SSK2
MAP kinase kinase kinase SSK2

2

20

High-throughput

0.793

High

628365

SIS1
Protein SIS1

2

10

High-throughput

0.789

High

961924

SKG3
Protein SKG3

2

0

High-throughput

0.770

High

339792

CDK1
Cyclin-dependent kinase 1

2

16

Small-scale

0.767

High

961899

SLT2
Mitogen-activated protein kinase SLT2/MPK1

2

17

Small-scale

0.754

High

814149

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

6

Small-scale

0.747

High

961941

RLM1
Transcription factor RLM1

6

15

Small-scale

0.733

High

689372

ARP2
Actin-related protein 2

1

8

High-throughput

0.691

High

784316

SMK1
Sporulation-specific mitogen-activated protein kinase SMK1

1

19

High-throughput

0.691

High

819480

DSK2
Ubiquitin domain-containing protein DSK2

1

5

High-throughput

0.691

High

961953

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

9

High-throughput

0.691

High

375473

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

4

Small-scale

0.667

High

744083

PP2C4
Protein phosphatase 2C homolog 4

1

12

Small-scale

0.647

High

752183

KSP1
Serine/threonine-protein kinase KSP1

1

20

High-throughput

0.647

High

765758

PP2C2
Protein phosphatase 2C homolog 2

1

13

Small-scale

0.647

High

961911

STE20
Serine/threonine-protein kinase STE20

1

14

Small-scale

0.647

High

961920

AVO2
Target of rapamycin complex 2 subunit AVO2

1

4

Small-scale

0.647

High

629024

SCJ1
DnaJ-related protein SCJ1

1

11

High-throughput

0.646

High

633486

MAS5
Mitochondrial protein import protein MAS5

1

12

High-throughput

0.646

High

715840

MDJ1
DnaJ homolog 1, mitochondrial

1

13

High-throughput

0.646

High

887648

ACT
Actin

1

8

High-throughput

0.646

High

667364

PTP2
Tyrosine-protein phosphatase 2

2

20

Small-scale

0.639

High

613078

SPA2
Protein SPA2

3

9

Small-scale

0.637

High

409671

KAPC
cAMP-dependent protein kinase type 3

1

20

High-throughput

0.621

High

412840

KAPA
cAMP-dependent protein kinase type 1

1

18

High-throughput

0.621

High

516820

SST2
Protein SST2

1

2

High-throughput

0.621

High

624709

CG22
G2/mitotic-specific cyclin-2

1

4

High-throughput

0.621

High

701664

STE5
Protein STE5

1

2

High-throughput

0.621

High

743177

BOB1
Protein BOB1

1

9

High-throughput

0.621

High

760584

SSN3
Meiotic mRNA stability protein kinase SSN3

1

19

High-throughput

0.621

High

866099

TEP1
Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1

1

3

High-throughput

0.621

High

866756

CRZ1
Transcriptional regulator CRZ1

1

2

High-throughput

0.621

High

961923

FAR10
Factor arrest protein 10

1

1

High-throughput

0.621

High

961949

ARP6
Actin-like protein ARP6

1

9

High-throughput

0.621

High

961950

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

11

High-throughput

0.621

High

416321

SIR3
Regulatory protein SIR3

2

2

Small-scale

0.619

High

851031

ROM2
RHO1 GDP-GTP exchange protein 2

2

9

Small-scale

0.619

High

434776

PBS2
MAP kinase kinase PBS2

1

20

Small-scale

0.618

High

605575

DBF2
Cell cycle protein kinase DBF2

1

11

High-throughput

0.618

High

649916

CDC15
Cell division control protein 15

1

20

High-throughput

0.618

High

687592

DBF20
Serine/threonine-protein kinase DBF20

1

11

High-throughput

0.618

High

691103

HOG1
Mitogen-activated protein kinase HOG1

1

18

Small-scale

0.618

High

961457

CDC14
Tyrosine-protein phosphatase CDC14

1

20

High-throughput

0.618

High

693417

SMI1
Cell wall assembly regulator SMI1

2

0

Small-scale

0.615

High

961938

RCN2
Regulator of calcineurin 2

2

0

Small-scale

0.602

High

772729

MPM1
Mitochondrial peculiar membrane protein 1

2

0

High-throughput

0.592

High

699804

KPR1
Ribose-phosphate pyrophosphokinase 1

2

9

Small-scale

0.586

High

749000

PAF1
RNA polymerase II-associated protein 1

1

1

Small-scale

0.573

High

695309

HSP7F
Heat shock protein homolog SSE1

2

20

Small-scale

0.571

High

625982

PTP1
Tyrosine-protein phosphatase 1

1

15

Small-scale

0.561

High

634894

MRC1
Mediator of replication checkpoint protein 1

1

1

Small-scale

0.561

High

751497

SIC1
Protein SIC1

1

1

Small-scale

0.561

High

530020

STE12
Protein STE12

1

4

High-throughput

0.554

High

758691

TEM1
Protein TEM1

1

3

High-throughput

0.553

High

666276

BEM1
Bud emergence protein 1

1

5

High-throughput

0.552

High

697325

GLRX4
Monothiol glutaredoxin-4

1

7

Small-scale

0.552

High

961914

GLRX3
Monothiol glutaredoxin-3

1

6

Small-scale

0.552

High

524416

CAF20
Cap-associated protein CAF20

1

1

Small-scale

0.536

High

393607

PMA1
Plasma membrane ATPase 1

1

6

High-throughput

0.536

High

424229

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

3

High-throughput

0.536

High

439537

SYFM
Phenylalanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

439559

GAL7
Galactose-1-phosphate uridylyltransferase

1

1

High-throughput

0.536

High

485805

IF4A
ATP-dependent RNA helicase eIF4A

1

11

High-throughput

0.536

High

640760

PDC6
Pyruvate decarboxylase isozyme 3

1

2

High-throughput

0.536

High

660931

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

4

High-throughput

0.536

High

703840

PRS6B
26S proteasome regulatory subunit 6B homolog

1

4

High-throughput

0.536

High

731133

LHS1
Heat shock protein 70 homolog LHS1

1

19

High-throughput

0.536

High

742938

GBLP
Small ribosomal subunit protein RACK1

1

14

High-throughput

0.536

High

753240

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

1

High-throughput

0.536

High

756705

NACA
Nascent polypeptide-associated complex subunit alpha

1

2

High-throughput

0.536

High

774659

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

6

High-throughput

0.536

High

777134

MKT1
Post-transcriptional regulator MKT1

1

1

High-throughput

0.536

High

858753

ROM1
RHO1 GDP-GTP exchange protein 1

1

10

High-throughput

0.536

High

864170

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

3

High-throughput

0.536

High

961907

DIG1
Down-regulator of invasive growth 1

1

3

High-throughput

0.536

High

961913

OYE2
NADPH dehydrogenase 2

1

1

High-throughput

0.536

High

961936

SOG2
Leucine-rich repeat-containing protein SOG2

1

12

High-throughput

0.536

High

858837

RTF1
RNA polymerase-associated protein RTF1

1

1

Small-scale

0.529

High

953676

CTR9
RNA polymerase-associated protein CTR9

1

1

Small-scale

0.529

High

961903

ADA2
Transcriptional adapter 2

1

5

Small-scale

0.529

High

961930

CYK3
Cytokinesis protein 3

1

0

Small-scale

0.518

High

866355

NST1
Stress response protein NST1

1

8

Small-scale

0.515

High

961925

GGA1
ADP-ribosylation factor-binding protein GGA1

1

0

Small-scale

0.513

High

341828

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.513

High

410824

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.513

High

592963

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.513

High

704402

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.513

High

847973

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.513

High

860571

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.513

High

961910

EBS1
Nonsense-mediated mRNA decay factor EBS1

1

0

High-throughput

0.513

High

961935

DIA2
Protein DIA2

1

0

High-throughput

0.513

High

961947

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.513

High

750631

LEO1
RNA polymerase-associated protein LEO1

1

0

Small-scale

0.506

High

961928

CDC73
Cell division control protein 73

1

0

Small-scale

0.506

High

961908

GCN5
Histone acetyltransferase GCN5

1

9

Small-scale

0.506

High

767534

TSC11
Target of rapamycin complex 2 subunit TSC11

1

2

Small-scale

0.501

High

797986

IRC5
Uncharacterized ATP-dependent helicase IRC5

1

2

High-throughput

0.501

High

342091

ATPB
ATP synthase subunit beta, mitochondrial

1

12

High-throughput

0.500

High

342378

CISY1
Citrate synthase, mitochondrial

1

2

High-throughput

0.500

High

343670

PMG1
Phosphoglycerate mutase 1

1

2

High-throughput

0.500

High

378385

LEU3
3-isopropylmalate dehydrogenase

1

6

High-throughput

0.500

High

381475

GAL1
Galactokinase

1

1

High-throughput

0.500

High

389320

HXKA
Hexokinase-1

1

3

High-throughput

0.500

High

423895

ATPA
ATP synthase subunit alpha, mitochondrial

1

12

High-throughput

0.500

High

424664

PYR1
Multifunctional protein URA2

1

10

High-throughput

0.500

High

498574

METK1
S-adenosylmethionine synthase 1

1

5

High-throughput

0.500

High

521035

G6PI
Glucose-6-phosphate isomerase

1

2

High-throughput

0.500

High

554719

HSP26
Heat shock protein 26

1

7

High-throughput

0.500

High

562422

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

12

High-throughput

0.500

High

570715

HXKG
Glucokinase-1

1

3

High-throughput

0.500

High

581313

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.500

High

583250

METK2
S-adenosylmethionine synthase 2

1

5

High-throughput

0.500

High

604457

CLH
Clathrin heavy chain

1

2

High-throughput

0.500

High

619625

MPCP
Mitochondrial phosphate carrier protein

1

13

High-throughput

0.500

High

630823

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

6

High-throughput

0.500

High

636713

CDC48
Cell division control protein 48

1

6

High-throughput

0.500

High

785164

MPG1
Mannose-1-phosphate guanyltransferase

1

4

High-throughput

0.500

High

961901

PRS8
26S proteasome regulatory subunit 8 homolog

1

6

High-throughput

0.500

High

961933

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.500

High

961943

HSP42
Heat shock protein 42

1

7

High-throughput

0.500

High

961945

RPN6
26S proteasome regulatory subunit RPN6

1

2

High-throughput

0.489

High

514585

BIK1
Nuclear fusion protein BIK1

1

2

High-throughput

0.481

High

514645

FUS1
Nuclear fusion protein FUS1

1

2

High-throughput

0.481

High

599984

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

1

High-throughput

0.481

High

629346

MSH3
DNA mismatch repair protein MSH3

1

2

High-throughput

0.481

High

630371

SED4
Putative guanine nucleotide-exchange factor SED4

1

2

High-throughput

0.481

High

639283

MSH2
DNA mismatch repair protein MSH2

1

2

High-throughput

0.481

High

653817

PEP3
Vacuolar membrane protein PEP3

1

1

High-throughput

0.481

High

675808

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.481

High

698246

CACP
Carnitine O-acetyltransferase, mitochondrial

1

1

High-throughput

0.481

High

703167

UFD4
Ubiquitin fusion degradation protein 4

1

3

High-throughput

0.481

High

704931

PACC
pH-response transcription factor pacC/RIM101

1

9

High-throughput

0.481

High

731429

MID2
Cell wall integrity sensor MID2

1

1

High-throughput

0.481

High

732169

CAB3
Coenzyme A biosynthesis protein 3

1

1

High-throughput

0.481

High

741557

VRP1
Verprolin

1

7

High-throughput

0.481

High

743338

KPR4
Ribose-phosphate pyrophosphokinase 4

1

9

Small-scale

0.481

High

744588

PCH2
Pachytene checkpoint protein 2

1

12

High-throughput

0.481

High

744835

ERT1
Transcription activator of gluconeogenesis ERT1

1

1

High-throughput

0.481

High

750993

KPR2
Ribose-phosphate pyrophosphokinase 2

1

9

Small-scale

0.481

High

751175

PSB1
Proteasome subunit beta type-1

1

4

Small-scale

0.481

High

752081

KPR3
Ribose-phosphate pyrophosphokinase 3

1

9

Small-scale

0.481

High

773821

VTH1
VPS10 homolog 1

1

1

High-throughput

0.481

High

773870

BNR1
BNI1-related protein 1

1

1

High-throughput

0.481

High

775570

MPH1
ATP-dependent DNA helicase MPH1

1

7

High-throughput

0.481

High

778547

RTS2
Zinc finger protein RTS2

1

1

High-throughput

0.481

High

784494

OYE3
NADPH dehydrogenase 3

1

1

High-throughput

0.481

High

798001

SA155
SIT4-associating protein SAP155

1

1

High-throughput

0.481

High

809845

RSF2
Respiration factor 2

1

3

High-throughput

0.481

High

811662

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

2

High-throughput

0.481

High

961902

SKO1
CRE-binding bZIP protein SKO1

1

1

High-throughput

0.481

High

961905

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

3

High-throughput

0.481

High

961918

GRH1
GRASP65 homolog protein 1

1

5

High-throughput

0.481

High

961926

TUS1
Rho1 guanine nucleotide exchange factor TUS1

1

9

High-throughput

0.481

High

961929

SSK1
Osmolarity two-component system protein SSK1

1

2

High-throughput

0.481

High

961932

YAP7
AP-1-like transcription factor YAP7

1

1

High-throughput

0.481

High

961939

ULA1
NEDD8-activating enzyme E1 regulatory subunit

1

2

High-throughput

0.481

High

692054

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

Small-scale

0.480

High

810441

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.480

High

558665

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.479

High

431395

LTE1
Guanine nucleotide exchange factor LTE1

1

4

High-throughput

0.479

High

503126

ARF1
ADP-ribosylation factor 1

1

3

High-throughput

0.479

High

558201

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

Small-scale

0.479

High

605253

AFT1
Iron-regulated transcriptional activator AFT1

1

1

Small-scale

0.479

High

621175

FPS1
Glycerol uptake/efflux facilitator protein

1

1

Small-scale

0.479

High

774492

MOB1
DBF2 kinase activator protein MOB1

1

2

High-throughput

0.479

High

797529

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

7

High-throughput

0.479

High

865400

BNI4
Protein BNI4

1

1

Small-scale

0.479

High

425246

PHO2
Regulatory protein PHO2

1

0

High-throughput

0.460

High

608754

CHL1
ATP-dependent DNA helicase CHL1

1

0

High-throughput

0.460

High

622066

SSD1
Protein SSD1

1

0

High-throughput

0.460

High

623864

MNE1
Protein MNE1

1

0

High-throughput

0.460

High

688106

COX24
Small ribosomal subunit protein mS38

1

0

High-throughput

0.460

High

688662

MCM10
Minichromosome maintenance protein 10

1

0

High-throughput

0.460

High

697884

ALK2
Serine/threonine-protein kinase Haspin homolog ALK2

1

0

High-throughput

0.460

High

699138

SEC6
Exocyst complex component SEC6

1

0

High-throughput

0.460

High

703021

PDR3
Transcription factor PDR3

1

0

High-throughput

0.460

High

730452

FOLC
Probable folylpolyglutamate synthase

1

0

High-throughput

0.460

High

732203

SRX1
Sulfiredoxin

1

0

High-throughput

0.460

High

745468

SFT2
Protein transport protein SFT2

1

0

High-throughput

0.460

High

747224

EXO84
Exocyst complex component EXO84

1

0

High-throughput

0.460

High

747898

UBS1
Ubiquitin-conjugating enzyme suppressor 1

1

0

High-throughput

0.460

High

748333

YBP1
YAP1-binding protein 1

1

0

High-throughput

0.460

High

748588

DPH7
Diphthine methyltransferase

1

0

High-throughput

0.460

High

754310

FYV4
Small ribosomal subunit protein mS41

1

0

High-throughput

0.460

High

755109

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

High-throughput

0.460

High

756060

WSS1
DNA-dependent metalloprotease WSS1

1

0

High-throughput

0.460

High

756908

AIM46
Altered inheritance of mitochondria protein 46, mitochondrial

1

0

High-throughput

0.460

High

763610

PEX22
Peroxisome assembly protein 22

1

0

High-throughput

0.460

High

775130

SYG1
Protein SYG1

1

0

High-throughput

0.460

High

775488

URM1
Ubiquitin-related modifier 1

1

0

High-throughput

0.460

High

791245

STB1
Protein STB1

1

0

High-throughput

0.460

High

797084

FMP32
Protein FMP32, mitochondrial

1

0

High-throughput

0.460

High

809518

TRS85
Trafficking protein particle complex III-specific subunit 85

1

0

High-throughput

0.460

High

860003

PIB2
Glutamine sensor PIB2

1

0

High-throughput

0.460

High

860460

LST7
Protein LST7

1

0

High-throughput

0.460

High

961906

INA17
Inner membrane assembly complex subunit 17

1

0

High-throughput

0.460

High

961909

CWC21
Pre-mRNA-splicing factor CWC21

1

0

High-throughput

0.460

High

961912

GOT1
Protein transport protein GOT1

1

0

High-throughput

0.460

High

961915

LIC4
Protein ATC1/LIC4

1

0

High-throughput

0.460

High

961916

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.460

High

961919

RBA50
RNA polymerase II-associated protein RBA50

1

0

High-throughput

0.460

High

961922

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

0

High-throughput

0.460

High

961927

OMS1
Methyltransferase OMS1, mitochondrial

1

0

High-throughput

0.460

High

961937

GRE1
Protein GRE1

1

0

High-throughput

0.460

High

961940

TIP41
Type 2A phosphatase activator TIP41

1

0

High-throughput

0.460

High

961942

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.460

High

961944

SCM3
Protein SCM3

1

0

High-throughput

0.460

High

961948

RKM4
Ribosomal lysine N-methyltransferase 4

1

0

High-throughput

0.460

High

961951

HUG1
MEC1-mediated checkpoint protein HUG1

1

0

High-throughput

0.460

High

961952

SRN2
Protein SRN2

1

0

High-throughput

0.460

High

540006

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

Small-scale

0.458

High

747193

FES1
Hsp70 nucleotide exchange factor FES1

1

0

Small-scale

0.458

High

961946

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.458

High

696908

TCA17
TRAPP-associated protein TCA17

1

1

High-throughput

0.457

High

492139

HSP71
Heat shock protein SSA1

1

17

High-throughput

0.445

High

512364

SSB1
Ribosome-associated molecular chaperone SSB1

1

19

High-throughput

0.445

High

769189

SSB2
Ribosome-associated molecular chaperone SSB2

1

19

High-throughput

0.445

High

547990

DAL5
Allantoate permease

1

3

High-throughput

0.439

High

675033

ITR2
Myo-inositol transporter 2

1

4

High-throughput

0.439

High

753640

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

3

High-throughput

0.439

High

766770

BIM1
Protein BIM1

1

5

High-throughput

0.439

High

873332

HXT15
Hexose transporter HXT15

1

4

High-throughput

0.439

High

961917

UTP15
U3 small nucleolar RNA-associated protein 15

1

4

High-throughput

0.439

High

961921

NUP59
Nucleoporin ASM4

1

1

High-throughput

0.439

High

961934

VHS3
Phosphopantothenoylcysteine decarboxylase subunit VHS3

1

1

High-throughput

0.439

High

748377

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.438

High

859658

USE1
Protein transport protein USE1

1

0

High-throughput

0.261

Low

961904

YP077
Uncharacterized protein YPL077C

1

0

High-throughput

0.261

Low

748926

BIT2
Probable target of rapamycin complex 2 subunit BIT2

1

0

High-throughput

0.251

Low

797905

PTR3
SPS-sensor component PTR3

1

0

High-throughput

0.251

Low

961931

PAU23
Seripauperin-23

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024