Protein: SEC66
Translocation protein SEC66 (Protein HSS1) (Sec62/63 complex 31.5 kDa subunit)

Gene: SEC66
Organism: Saccharomyces cerevisiae S288C
Interactions: 60
UniProt ID: P33754

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0030447 - filamentous growth
GO:0030867 - rough endoplasmic reticulum membrane
GO:0031204 - post-translational protein targeting to membrane, translocation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

748317

SC61A
Protein transport protein SEC61

5

1

Small-scale

0.917

High

577083

SEC63
Protein translocation protein SEC63

14

0

Small-scale

0.727

High

754398

SEC72
Translocation protein SEC72

8

0

Small-scale

0.717

High

641360

SEC62
Translocation protein SEC62

5

0

Small-scale

0.684

High

754391

SSH1
Sec sixty-one protein homolog

1

1

Small-scale

0.647

High

754383

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

2

2

High-throughput

0.601

High

754385

YET1
Endoplasmic reticulum transmembrane protein 1

2

1

Small-scale

0.584

High

754384

SC61G
Protein transport protein SSS1

2

0

Small-scale

0.547

High

754408

SC6B1
Protein transport protein SBH1

1

0

Small-scale

0.546

High

754393

YHE2
Putative uncharacterized protein YHL042W

1

0

High-throughput

0.518

High

754402

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.518

High

754404

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

0

High-throughput

0.518

High

631886

SRP54
Signal recognition particle subunit SRP54

1

0

Small-scale

0.480

High

554328

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

1

High-throughput

0.479

High

554410

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

1

High-throughput

0.479

High

726071

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

2

High-throughput

0.479

High

754397

HPH2
Protein HPH2

1

1

Small-scale

0.479

High

754405

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

2

High-throughput

0.479

High

754411

TMEDA
Endoplasmic reticulum vesicle protein 25

1

1

High-throughput

0.479

High

754417

ERP1
Protein ERP1

1

1

High-throughput

0.479

High

754418

YET3
Endoplasmic reticulum transmembrane protein 3

1

1

High-throughput

0.479

High

754421

HPH1
Protein HPH1

1

1

Small-scale

0.479

High

506216

MPH3
Alpha-glucosides permease MPH3

1

0

High-throughput

0.460

High

754406

STE24
CAAX prenyl protease 1

1

0

Small-scale

0.460

High

597101

BIP
Endoplasmic reticulum chaperone BiP

1

0

Small-scale

0.458

High

636296

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.458

High

672145

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

0

High-throughput

0.458

High

676852

RER1
Protein RER1

1

0

Small-scale

0.458

High

677099

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

677998

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

751684

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.458

High

754382

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

0

High-throughput

0.458

High

754386

MCD4
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.458

High

754387

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

754389

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

754390

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.458

High

754392

LAG1
Ceramide synthase LAG1

1

0

High-throughput

0.458

High

754394

NSG1
Protein NSG1

1

0

High-throughput

0.458

High

754396

STT3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

1

0

High-throughput

0.458

High

754399

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.458

High

754401

ELO3
Fatty acid elongase 3

1

0

High-throughput

0.458

High

754403

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.458

High

754407

HLJ1
Protein HLJ1

1

0

High-throughput

0.458

High

754409

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

0

High-throughput

0.458

High

754413

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

0

High-throughput

0.458

High

754415

CUE4
CUE domain-containing protein CUE4

1

0

High-throughput

0.458

High

754416

SPC2
Signal peptidase complex subunit 2

1

0

High-throughput

0.458

High

754420

PGA3
Plasma membrane-associated coenzyme Q6 reductase PGA3

1

0

High-throughput

0.458

High

754412

SED5
Integral membrane protein SED5

1

0

Small-scale

0.426

High

754400

PIC2
Mitochondrial phosphate carrier protein 2

1

0

High-throughput

0.282

High

754395

TEM1
Protein TEM1

1

0

High-throughput

0.265

Low

713218

SEC65
Signal recognition particle subunit SEC65

1

0

Small-scale

0.261

Low

579135

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

706672

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

754388

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.249

Low

754414

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.249

Low

754419

YD157
Uncharacterized protein YDL157C, mitochondrial

1

0

Small-scale

0.249

Low

673398

PRTD
Saccharolysin

1

0

High-throughput

0.238

Low

544343

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.232

Low

754410

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025