Protein: CUE4
CUE domain-containing protein CUE4 (Coupling of ubiquitin conjugation to ER degradation protein 4)

Gene: CUE4
Organism: Saccharomyces cerevisiae S288C
Interactions: 51
UniProt ID: Q04201

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0043130 - ubiquitin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

866132

ILM1
Protein ILM1

3

0

High-throughput

0.626

High

1045193

GET3
ATPase GET3

2

0

High-throughput

0.594

High

580018

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.584

High

438548

UBC2
Ubiquitin-conjugating enzyme E2 2

1

0

High-throughput

0.493

High

393285

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

726115

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

2

High-throughput

0.479

High

754721

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

2

High-throughput

0.479

High

776389

YET1
Endoplasmic reticulum transmembrane protein 1

1

1

High-throughput

0.479

High

863383

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

2

High-throughput

0.479

High

1045189

YET3
Endoplasmic reticulum transmembrane protein 3

1

1

High-throughput

0.479

High

449177

CALM
Calmodulin

1

0

High-throughput

0.458

High

577210

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.458

High

636345

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.458

High

641395

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

672175

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

0

High-throughput

0.458

High

677118

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

678023

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

748535

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.458

High

754415

SEC66
Translocation protein SEC66

1

0

High-throughput

0.458

High

754657

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

0

High-throughput

0.458

High

763262

SQT1
Ribosome assembly protein SQT1

1

0

High-throughput

0.458

High

780362

MCD4
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.458

High

797051

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

809033

STT3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

1

0

High-throughput

0.458

High

812900

SOP4
Protein SOP4

1

0

High-throughput

0.458

High

816213

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.458

High

822336

ELO3
Fatty acid elongase 3

1

0

High-throughput

0.458

High

826151

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

828318

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

835067

OST1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

850939

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.458

High

864075

SFH5
Phosphatidylinositol transfer protein SFH5

1

0

High-throughput

0.458

High

865892

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

916931

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

923872

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.458

High

924146

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

0

High-throughput

0.458

High

1042224

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.458

High

1045185

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.458

High

1045187

SPC2
Signal peptidase complex subunit 2

1

0

High-throughput

0.458

High

1045188

ERP1
Protein ERP1

1

0

High-throughput

0.458

High

1045191

EMC10
Endoplasmic reticulum membrane protein complex subunit 10

1

0

High-throughput

0.458

High

1045186

RTN1
Reticulon-like protein 1

1

0

High-throughput

0.438

High

546170

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

866009

VPS25
Vacuolar protein-sorting-associated protein 25

1

0

High-throughput

0.282

High

1045190

YO075
Uncharacterized ABC transporter ATP-binding protein/permease YOL075C

1

0

High-throughput

0.282

High

708098

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

713236

SEC65
Signal recognition particle subunit SEC65

1

0

High-throughput

0.249

Low

779982

EMC3
ER membrane protein complex subunit 3

1

0

High-throughput

0.249

Low

826275

SNL1
HSP70 co-chaperone SNL1

1

0

High-throughput

0.249

Low

1038800

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

0

High-throughput

0.249

Low

1045192

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025