Protein: LAS1
Protein LAS1

Gene: LAS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 85
UniProt ID: P36146

Gene Ontology (top 5):
GO:0000448 - cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000460 - maturation of 5.8S rRNA
GO:0000470 - maturation of LSU-rRNA
GO:0004519 - endonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

782187

GRC3
Polynucleotide 5'-hydroxyl-kinase GRC3

10

2

Small-scale

0.976

High

782177

XRN2
5'-3' exoribonuclease 2

4

2

Small-scale

0.676

High

782172

DXO
Decapping nuclease RAI1

3

0

Small-scale

0.613

High

782156

LAS1
Protein LAS1

1

0

Small-scale

0.586

High

721852

XPO1
Exportin-1

1

1

High-throughput

0.536

High

736511

SFP1
Transcription factor SFP1

1

0

High-throughput

0.513

High

484754

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

Small-scale

0.479

High

632553

DBP3
ATP-dependent RNA helicase DBP3

1

1

Small-scale

0.479

High

645371

XRN1
5'-3' exoribonuclease 1

1

2

Small-scale

0.479

High

666438

DBP2
ATP-dependent RNA helicase DBP2

1

1

Small-scale

0.479

High

694528

SPT5
Transcription elongation factor SPT5

1

1

Small-scale

0.479

High

727667

TPS2
Trehalose-phosphatase

1

1

Small-scale

0.479

High

782159

TSL1
Trehalose synthase complex regulatory subunit TSL1

1

1

Small-scale

0.479

High

782165

ARB1
ABC transporter ATP-binding protein ARB1

1

2

Small-scale

0.479

High

782169

GSHR
Glutathione reductase

1

1

Small-scale

0.479

High

782178

NOG1
Nucleolar GTP-binding protein 1

1

1

Small-scale

0.479

High

782179

HAS1
ATP-dependent RNA helicase HAS1

1

1

Small-scale

0.479

High

782184

ERB1
Ribosome biogenesis protein ERB1

1

1

Small-scale

0.479

High

782188

NEW1
[NU+] prion formation protein 1

1

2

Small-scale

0.479

High

368234

TRP
Tryptophan synthase

1

0

Small-scale

0.458

High

417080

VDAC1
Non-selective voltage-gated ion channel 1

1

0

Small-scale

0.458

High

432318

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

Small-scale

0.458

High

433183

RL17A
Large ribosomal subunit protein uL22A

1

0

Small-scale

0.458

High

438670

SC160
Protein SCP160

1

0

Small-scale

0.458

High

512057

RS4A
Small ribosomal subunit protein eS4A

1

0

Small-scale

0.458

High

515240

RL35A
Large ribosomal subunit protein uL29A

1

0

Small-scale

0.458

High

517983

SSBP1
Single-stranded nucleic acid-binding protein

1

0

Small-scale

0.458

High

534252

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

0

Small-scale

0.458

High

569972

RL3
Large ribosomal subunit protein uL3

1

0

Small-scale

0.458

High

577104

SEC63
Protein translocation protein SEC63

1

0

Small-scale

0.458

High

601020

RL8A
Large ribosomal subunit protein eL8A

1

0

Small-scale

0.458

High

613560

ADT2
ADP,ATP carrier protein 2

1

0

Small-scale

0.458

High

635954

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

0

Small-scale

0.458

High

639005

VPS1
Vacuolar protein sorting-associated protein 1

1

0

Small-scale

0.458

High

642137

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

Small-scale

0.458

High

644909

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

Small-scale

0.458

High

670582

SIS1
Protein SIS1

1

0

Small-scale

0.458

High

674551

RS2
Small ribosomal subunit protein uS5

1

0

Small-scale

0.458

High

676913

SRO9
RNA-binding protein SRO9

1

0

Small-scale

0.458

High

688864

RS5
Small ribosomal subunit protein uS7

1

0

Small-scale

0.458

High

692553

NSR1
Nuclear localization sequence-binding protein

1

0

Small-scale

0.458

High

706811

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

735820

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

Small-scale

0.458

High

743185

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

Small-scale

0.458

High

746268

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

Small-scale

0.458

High

750629

PRS6A
26S proteasome regulatory subunit 6A

1

0

Small-scale

0.458

High

751375

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

Small-scale

0.458

High

782157

SYG
Glycine--tRNA ligase 1, mitochondrial

1

0

Small-scale

0.458

High

782158

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

0

Small-scale

0.458

High

782160

SSF1
Ribosome biogenesis protein SSF1

1

0

Small-scale

0.458

High

782161

RIX1
Pre-rRNA-processing protein RIX1

1

0

Small-scale

0.458

High

782162

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

Small-scale

0.458

High

782163

IF2P
Eukaryotic translation initiation factor 5B

1

0

Small-scale

0.458

High

782167

MGDP1
Putative magnesium-dependent phosphatase YER134C

1

0

High-throughput

0.458

High

782168

NOP2
25S rRNA

1

0

Small-scale

0.458

High

782170

RS7B
Small ribosomal subunit protein eS7B

1

0

Small-scale

0.458

High

782171

ACS2
Acetyl-coenzyme A synthetase 2

1

0

Small-scale

0.458

High

782173

NSA1
Ribosome biogenesis protein NSA1

1

0

Small-scale

0.458

High

782174

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

782176

YNE6
Uncharacterized endoplasmic reticulum membrane protein YNL046W

1

0

High-throughput

0.458

High

782180

ARX1
Probable metalloprotease ARX1

1

0

Small-scale

0.458

High

782185

RRP5
rRNA biogenesis protein RRP5

1

0

Small-scale

0.458

High

782186

YL271
Uncharacterized protein YLR271W

1

0

High-throughput

0.458

High

782189

MDN1
Midasin

1

0

Small-scale

0.458

High

782190

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

782191

RRP12
Ribosomal RNA-processing protein 12

1

0

Small-scale

0.458

High

523637

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

526423

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

741373

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

782175

COPA
Coatomer subunit alpha

1

1

Small-scale

0.437

High

544502

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

782164

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.426

High

782183

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.426

High

383638

RS17A
Small ribosomal subunit protein eS17A

1

0

Small-scale

0.249

Low

454997

RS19A
Small ribosomal subunit protein eS19A

1

0

Small-scale

0.249

Low

511652

RS23B
Small ribosomal subunit protein uS12B

1

0

High-throughput

0.249

Low

513483

RL1A
Large ribosomal subunit protein uL1A

1

0

Small-scale

0.249

Low

514265

RL12B
Large ribosomal subunit protein uL11B

1

0

Small-scale

0.249

Low

582446

SEC23
Protein transport protein SEC23

1

0

Small-scale

0.249

Low

613763

MDM10
Mitochondrial distribution and morphology protein 10

1

0

High-throughput

0.249

Low

673463

RHEB
GTP-binding protein RHB1

1

0

High-throughput

0.249

Low

782166

TMN3
Transmembrane 9 superfamily member 3

1

0

Small-scale

0.249

Low

782181

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

Small-scale

0.249

Low

782182

GPI19
Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI19

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025