Protein: HFQ
RNA-binding protein Hfq (HF-1) (Host factor-I protein) (HF-I)

Gene: HFQ
Organism: Escherichia coli K-12
Interactions: 80
UniProt ID: P0A6X3

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0003677 - DNA binding
GO:0003681 - bent DNA binding
GO:0003723 - RNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

490845

HFQ
RNA-binding protein Hfq

1

1

Small-scale

0.647

High

490872

CSPA
Cold shock protein CspA

2

3

High-throughput

0.601

High

490903

CSPB
Cold shock-like protein CspB

2

3

High-throughput

0.601

High

490868

CSPE
Cold shock-like protein CspE

2

3

High-throughput

0.588

High

490873

CSPC
Cold shock-like protein CspC

2

3

High-throughput

0.588

High

490878

DBHB
DNA-binding protein HU-beta

2

1

High-throughput

0.588

High

490890

EFTU1
Elongation factor Tu 1

2

1

High-throughput

0.588

High

490893

SELB
Selenocysteine-specific elongation factor

2

2

High-throughput

0.588

High

490897

LPXD
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

2

1

High-throughput

0.588

High

490886

RHO
Transcription termination factor Rho

2

0

Small-scale

0.586

High

490860

RS4
Small ribosomal subunit protein uS4

2

0

High-throughput

0.585

High

490907

RL2
Large ribosomal subunit protein uL2

2

0

High-throughput

0.585

High

490848

PGK
Phosphoglycerate kinase

2

0

High-throughput

0.563

High

490849

RL7
Large ribosomal subunit protein bL12

2

0

High-throughput

0.563

High

490850

RL19
Large ribosomal subunit protein bL19

2

0

High-throughput

0.563

High

490852

RL20
Large ribosomal subunit protein bL20

2

0

High-throughput

0.563

High

490853

RL28
Large ribosomal subunit protein bL28

2

0

High-throughput

0.563

High

490854

RL9
Large ribosomal subunit protein bL9

2

0

High-throughput

0.563

High

490857

RS18
Small ribosomal subunit protein bS18

2

0

High-throughput

0.563

High

490863

TGT
Queuine tRNA-ribosyltransferase

2

0

High-throughput

0.563

High

490870

LON
Lon protease

2

0

High-throughput

0.563

High

490874

RL13
Large ribosomal subunit protein uL13

2

0

High-throughput

0.563

High

490885

SPOT
Bifunctional

2

0

High-throughput

0.563

High

490909

RL24
Large ribosomal subunit protein uL24

2

0

High-throughput

0.563

High

490910

RL4
Large ribosomal subunit protein uL4

2

0

High-throughput

0.563

High

490912

NFI
Endonuclease V

2

0

High-throughput

0.563

High

490913

CSRA
Carbon storage regulator

2

0

High-throughput

0.563

High

444268

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

490879

ROB
Right origin-binding protein

1

0

High-throughput

0.513

High

490881

RL14
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

490882

ELAB
Protein ElaB

1

0

High-throughput

0.513

High

490899

FLIS
Flagellar secretion chaperone FliS

1

0

High-throughput

0.513

High

490900

PSUK
Pseudouridine kinase

1

0

High-throughput

0.513

High

421090

PNP
Polyribonucleotide nucleotidyltransferase

1

1

High-throughput

0.484

High

490847

LPXA
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

1

1

High-throughput

0.484

High

490869

RNG
Ribonuclease G

1

1

High-throughput

0.484

High

490877

DBHA
DNA-binding protein HU-alpha

1

1

High-throughput

0.484

High

490888

RS1
Small ribosomal subunit protein bS1

1

1

High-throughput

0.484

High

490896

RNE
Ribonuclease E

1

1

High-throughput

0.484

High

382540

RS6
Small ribosomal subunit protein bS6

1

0

High-throughput

0.464

High

382627

RS7
Small ribosomal subunit protein uS7

1

0

High-throughput

0.464

High

473241

DNAJ
Chaperone protein DnaJ

1

0

High-throughput

0.464

High

490571

ENO
Enolase

1

0

High-throughput

0.464

High

490846

DNAK
Chaperone protein DnaK

1

0

High-throughput

0.464

High

490851

RL1
Large ribosomal subunit protein uL1

1

0

High-throughput

0.464

High

490855

RS13
Small ribosomal subunit protein uS13

1

0

High-throughput

0.464

High

490859

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.464

High

490861

RS5
Small ribosomal subunit protein uS5

1

0

High-throughput

0.464

High

490862

RPOA
DNA-directed RNA polymerase subunit alpha

1

0

High-throughput

0.464

High

490864

TIG
Trigger factor

1

0

High-throughput

0.464

High

490866

RPOC
DNA-directed RNA polymerase subunit beta'

1

0

High-throughput

0.464

High

490867

RPOB
DNA-directed RNA polymerase subunit beta

1

0

High-throughput

0.464

High

490871

DEAD
ATP-dependent RNA helicase DeaD

1

0

High-throughput

0.464

High

490876

DPS
DNA protection during starvation protein

1

0

High-throughput

0.464

High

490883

SKP
Chaperone protein Skp

1

0

High-throughput

0.464

High

490887

RL21
Large ribosomal subunit protein bL21

1

0

High-throughput

0.464

High

490889

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

1

0

High-throughput

0.464

High

490892

SECA
Protein translocase subunit SecA

1

0

High-throughput

0.464

High

490895

RNR
Ribonuclease R

1

0

High-throughput

0.464

High

490902

AIDB
Putative acyl-CoA dehydrogenase AidB

1

0

High-throughput

0.464

High

490904

RLUB
Ribosomal large subunit pseudouridine synthase B

1

0

High-throughput

0.464

High

490906

HRPA
ATP-dependent RNA helicase HrpA

1

0

High-throughput

0.464

High

490908

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.464

High

490911

RL22
Large ribosomal subunit protein uL22

1

0

High-throughput

0.464

High

490914

RLMKL
Ribosomal RNA large subunit methyltransferase K/L [Includes: 23S rRNA m2G2445 methyltransferase

1

0

High-throughput

0.464

High

490891

EFTU2
Elongation factor Tu 2

1

1

High-throughput

0.445

High

490875

PCNB
Poly(A) polymerase I

1

0

Small-scale

0.426

High

383985

RL15
Large ribosomal subunit protein uL15

2

0

High-throughput

0.307

High

490856

RS16
Small ribosomal subunit protein bS16

2

0

High-throughput

0.307

High

490865

YACL
UPF0231 protein YacL

2

0

High-throughput

0.307

High

469354

YCIH
Uncharacterized protein YciH

1

0

High-throughput

0.279

Low

490880

YECF
Uncharacterized protein YecF

1

0

High-throughput

0.279

Low

490884

YJFI
Uncharacterized protein YjfI

1

0

High-throughput

0.279

Low

490894

AGP
Glucose-1-phosphatase

1

0

High-throughput

0.279

Low

490898

YGBA
Uncharacterized protein YgbA

1

0

High-throughput

0.279

Low

490905

USPG
Universal stress protein UP12

1

0

High-throughput

0.279

Low

490915

YOBB
Uncharacterized protein YobB

1

0

High-throughput

0.279

Low

490858

RS2
Small ribosomal subunit protein uS2

1

0

High-throughput

0.253

Low

490901

3PASE
Inorganic triphosphatase

1

0

High-throughput

0.253

Low


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Last updated: 11Aug2025