Protein: RNR
Ribonuclease R (RNase R) (EC 3.1.13.1) (Protein VacB)

Gene: RNR
Organism: Escherichia coli K-12
Interactions: 68
UniProt ID: P21499

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0003723 - RNA binding
GO:0004540 - RNA nuclease activity
GO:0005829 - cytosol
GO:0006397 - mRNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

493312

RS11
Small ribosomal subunit protein uS11

2

1

High-throughput

0.759

High

382583

RS6
Small ribosomal subunit protein bS6

2

0

High-throughput

0.748

High

382709

RS7
Small ribosomal subunit protein uS7

2

0

High-throughput

0.748

High

638573

RNE
Ribonuclease E

2

0

High-throughput

0.748

High

493541

RS18
Small ribosomal subunit protein bS18

2

0

High-throughput

0.720

High

638582

RL24
Large ribosomal subunit protein uL24

2

0

High-throughput

0.720

High

496289

CSPE
Cold shock-like protein CspE

3

5

High-throughput

0.643

High

497419

CSPC
Cold shock-like protein CspC

3

5

High-throughput

0.643

High

501380

RS1
Small ribosomal subunit protein bS1

1

2

High-throughput

0.625

High

493778

RS2
Small ribosomal subunit protein uS2

1

2

High-throughput

0.618

High

638579

RLUB
Ribosomal large subunit pseudouridine synthase B

2

2

High-throughput

0.611

High

490934

IHFA
Integration host factor subunit alpha

2

1

High-throughput

0.588

High

492749

RL1
Large ribosomal subunit protein uL1

2

3

High-throughput

0.588

High

493401

RS13
Small ribosomal subunit protein uS13

2

1

High-throughput

0.588

High

493932

RS3
Small ribosomal subunit protein uS3

2

2

High-throughput

0.588

High

494381

RS8
Small ribosomal subunit protein uS8

2

2

High-throughput

0.588

High

494459

RS9
Small ribosomal subunit protein uS9

2

2

High-throughput

0.588

High

496263

CSPD
Cold shock-like protein CspD

2

5

High-throughput

0.588

High

499070

DBHA
DNA-binding protein HU-alpha

2

1

High-throughput

0.588

High

499974

RS15
Small ribosomal subunit protein uS15

2

1

High-throughput

0.588

High

638580

RL2
Large ribosomal subunit protein uL2

2

2

High-throughput

0.588

High

638591

RLMI
Ribosomal RNA large subunit methyltransferase I

2

1

High-throughput

0.584

High

491505

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

2

0

High-throughput

0.563

High

491945

RPPH
RNA pyrophosphohydrolase

2

0

High-throughput

0.563

High

492840

RL20
Large ribosomal subunit protein bL20

2

0

High-throughput

0.563

High

494120

RS4
Small ribosomal subunit protein uS4

2

0

High-throughput

0.563

High

501237

RL21
Large ribosomal subunit protein bL21

2

0

High-throughput

0.563

High

501278

RL6
Large ribosomal subunit protein uL6

2

0

High-throughput

0.563

High

638587

RS21
Small ribosomal subunit protein bS21

2

0

High-throughput

0.563

High

497631

RLUC
Ribosomal large subunit pseudouridine synthase C

1

2

High-throughput

0.561

High

384036

RL15
Large ribosomal subunit protein uL15

2

1

High-throughput

0.558

High

569566

SELB
Selenocysteine-specific elongation factor

2

1

High-throughput

0.558

High

638574

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase PssA

1

0

High-throughput

0.537

High

638578

RLMN
Dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.537

High

494303

RS5
Small ribosomal subunit protein uS5

1

3

High-throughput

0.536

High

638577

PGM
Phosphoglucomutase

1

1

High-throughput

0.536

High

638581

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.536

High

638590

RLMKL
Ribosomal RNA large subunit methyltransferase K/L [Includes: 23S rRNA m2G2445 methyltransferase

1

1

High-throughput

0.536

High

449911

CCA
Multifunctional CCA protein [Includes: CCA-adding enzyme

1

1

High-throughput

0.489

High

494893

TGT
Queuine tRNA-ribosyltransferase

1

1

High-throughput

0.484

High

497104

DEAD
ATP-dependent RNA helicase DeaD

1

5

High-throughput

0.484

High

497509

RL13
Large ribosomal subunit protein uL13

1

3

High-throughput

0.484

High

499873

RL14
Large ribosomal subunit protein uL14

1

1

High-throughput

0.484

High

638584

RL22
Large ribosomal subunit protein uL22

1

3

High-throughput

0.484

High

500334

FKBX
FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.479

High

490895

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.464

High

493165

RL9
Large ribosomal subunit protein bL9

1

0

High-throughput

0.464

High

493635

RS20
Small ribosomal subunit protein bS20

1

0

High-throughput

0.464

High

496730

PHOL
PhoH-like protein

1

0

High-throughput

0.464

High

497992

YBCJ
Putative RNA-binding protein YbcJ

1

0

High-throughput

0.464

High

500485

SKP
Chaperone protein Skp

1

0

High-throughput

0.464

High

501602

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

1

0

High-throughput

0.464

High

638583

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.464

High

495578

TMAR
Pole-localizer protein TmaR

1

0

High-throughput

0.458

High

495980

YFBU
UPF0304 protein YfbU

1

0

High-throughput

0.458

High

638586

GMHBB
D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase

1

0

High-throughput

0.458

High

638588

CSRA
Carbon storage regulator

1

0

High-throughput

0.458

High

498306

PCNB
Poly(A) polymerase I

1

1

Small-scale

0.445

High

638585

ISPF
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

1

1

High-throughput

0.417

High

638589

YBJX
Uncharacterized protein YbjX

2

0

High-throughput

0.318

High

493495

RS16
Small ribosomal subunit protein bS16

2

0

High-throughput

0.307

High

499895

RL16
Large ribosomal subunit protein uL16

2

0

High-throughput

0.307

High

499929

RL23
Large ribosomal subunit protein uL23

2

0

High-throughput

0.307

High

638575

3PASE
Inorganic triphosphatase

1

0

High-throughput

0.279

Low

501328

RS14
Small ribosomal subunit protein uS14

1

0

High-throughput

0.253

Low

501072

SOHB
Probable protease SohB

1

0

High-throughput

0.249

Low

638592

YNCE
Uncharacterized protein YncE

1

0

High-throughput

0.249

Low

638576

INTA
Prophage integrase IntA

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025