Protein: NOT4
General negative regulator of transcription subunit 4 (EC 2.3.2.27) (Modulator of transcription 2)

Gene: NOT4, MOT2
Organism: Saccharomyces cerevisiae S288C
Interactions: 75
UniProt ID: P34909

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening
GO:0003723 - RNA binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

549803

UBC4
Ubiquitin-conjugating enzyme E2 4

8

11

Small-scale

0.967

High

549854

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

4

11

Small-scale

0.881

High

636124

NOT1
General negative regulator of transcription subunit 1

18

1

Small-scale

0.764

High

713710

CAF40
Protein CAF40

14

2

Small-scale

0.758

High

680021

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

12

3

Small-scale

0.757

High

713728

NOT5
General negative regulator of transcription subunit 5

11

2

Small-scale

0.754

High

409979

NOT3
General negative regulator of transcription subunit 3

10

2

Small-scale

0.751

High

713691

POP2
Poly(A) ribonuclease POP2

9

3

Small-scale

0.748

High

409833

NOT2
General negative regulator of transcription subunit 2

8

3

Small-scale

0.745

High

713709

CF130
Protein CAF130

5

0

Small-scale

0.675

High

713702

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.624

High

713692

DHH1
ATP-dependent RNA helicase DHH1

2

2

Small-scale

0.614

High

713687

NOT4
General negative regulator of transcription subunit 4

2

1

Small-scale

0.595

High

713688

DEF1
RNA polymerase II degradation factor 1

2

0

High-throughput

0.588

High

490824

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.584

High

713717

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

2

Small-scale

0.581

High

645356

RS7A
Small ribosomal subunit protein eS7A

2

1

Small-scale

0.575

High

366082

HSP82
ATP-dependent molecular chaperone HSP82

2

0

High-throughput

0.559

High

700831

SMY2
Protein SMY2

2

0

Small-scale

0.559

High

635829

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

1

High-throughput

0.541

High

713282

WHI3
Protein WHI3

1

1

High-throughput

0.541

High

713705

JSN1
Protein JSN1

1

1

High-throughput

0.541

High

713707

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

Small-scale

0.537

High

710411

PIN4
RNA-binding protein PIN4

1

0

High-throughput

0.518

High

713713

NST1
Stress response protein NST1

1

0

High-throughput

0.518

High

713714

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

0

High-throughput

0.518

High

713716

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

Small-scale

0.512

High

597222

PSA7
Probable proteasome subunit alpha type-7

1

3

High-throughput

0.501

High

597308

PSA1
Proteasome subunit alpha type-1

1

2

High-throughput

0.501

High

619348

PSA3
Proteasome subunit alpha type-3

1

2

High-throughput

0.501

High

619444

PSA2
Proteasome subunit alpha type-2

1

3

High-throughput

0.501

High

689169

PSA5
Proteasome subunit alpha type-5

1

2

High-throughput

0.501

High

713695

PSA6
Proteasome subunit alpha type-6

1

2

High-throughput

0.501

High

713696

PSA4
Proteasome subunit alpha type-4

1

3

High-throughput

0.501

High

713706

JHD2
Histone demethylase JHD2

1

2

Small-scale

0.501

High

375347

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.480

High

425464

TFS2
Transcription elongation factor S-II

1

0

Small-scale

0.480

High

703575

PRS6A
26S proteasome regulatory subunit 6A

1

0

Small-scale

0.480

High

410350

SC160
Protein SCP160

1

1

High-throughput

0.479

High

498489

METK1
S-adenosylmethionine synthase 1

1

1

Small-scale

0.479

High

583214

METK2
S-adenosylmethionine synthase 2

1

1

Small-scale

0.479

High

713697

NACB2
Nascent polypeptide-associated complex subunit beta-2

1

2

High-throughput

0.479

High

713704

MTR4
ATP-dependent RNA helicase DOB1

1

1

Small-scale

0.479

High

713718

GIS1
Transcriptional activator/repressor GIS1

1

2

High-throughput

0.479

High

713727

RRP42
Exosome complex component RRP42

1

1

Small-scale

0.479

High

713729

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

2

Small-scale

0.479

High

608460

SAN1
Protein SAN1

1

0

Small-scale

0.460

High

557989

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

587839

AP1
AP-1-like transcription factor YAP1

1

0

Small-scale

0.458

High

644993

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.458

High

661846

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

713690

ECM29
Proteasome component ECM29

1

0

High-throughput

0.458

High

713693

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

Small-scale

0.458

High

713699

TM108
Protein TMA108

1

0

High-throughput

0.458

High

713701

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

713703

RRP41
Exosome complex component SKI6

1

0

Small-scale

0.458

High

713711

CA120
CCR4-NOT transcriptional complex subunit CAF120

1

0

Small-scale

0.458

High

713712

IGO1
mRNA stability protein IGO1

1

0

Small-scale

0.458

High

713715

H3
Histone H3

1

0

High-throughput

0.458

High

713719

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

713720

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.458

High

713721

HBT1
Protein HBT1

1

0

High-throughput

0.458

High

713724

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

713725

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

713726

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

713708

RS7B
Small ribosomal subunit protein eS7B

1

1

Small-scale

0.457

High

713722

WHI4
Protein WHI4

1

1

High-throughput

0.457

High

493618

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

510826

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

713694

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

713700

MET18
DNA repair/transcription protein MET18/MMS19

1

0

High-throughput

0.438

High

713723

RPN8
26S proteasome regulatory subunit RPN8

1

0

High-throughput

0.261

Low

713698

MLP2
Protein MLP2

1

0

Small-scale

0.249

Low

713689

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024