Protein: PDK2
[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial (PDK 2) (Pyruvate dehydrogenase kinase 2) (EC 2.7.11.2) (Protein kinase of PDH protein 2) (Pyruvate dehydrogenase complex kinase 2) (PDC kinase 2) ([Pyruvate dehydrogenase [lipoamide]] kinase 2)

Gene: PDK2, PKP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 100
UniProt ID: P53170

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004740 - pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

825962

PDK1
[Pyruvate dehydrogenase

3

13

Small-scale

0.855

High

393065

HSP82
ATP-dependent molecular chaperone HSP82

1

9

High-throughput

0.501

High

416267

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.501

High

437942

KAPC
cAMP-dependent protein kinase type 3

1

7

High-throughput

0.501

High

441196

KAPA
cAMP-dependent protein kinase type 1

1

8

High-throughput

0.501

High

441386

KAPB
cAMP-dependent protein kinase type 2

1

7

High-throughput

0.501

High

649646

KCC2
Calcium/calmodulin-dependent protein kinase II

1

2

High-throughput

0.501

High

704693

PRR1
Serine/threonine-protein kinase PRR1

1

1

High-throughput

0.501

High

739417

ZUO1
Zuotin

1

2

High-throughput

0.501

High

778912

NNK1
Nitrogen network kinase 1

1

2

High-throughput

0.501

High

792726

YPK3
Serine/threonine-protein kinase YPK3

1

5

High-throughput

0.501

High

801876

KSP1
Serine/threonine-protein kinase KSP1

1

5

High-throughput

0.501

High

805494

TOM71
Protein TOM71

1

3

High-throughput

0.501

High

817549

ICP55
Intermediate cleaving peptidase 55

1

1

High-throughput

0.501

High

825750

MAM33
Mitochondrial acidic protein MAM33

1

2

High-throughput

0.501

High

917127

ATG1
Serine/threonine-protein kinase ATG1

1

1

High-throughput

0.501

High

599666

STF2
ATPase-stabilizing factor 15 kDa protein

1

0

High-throughput

0.480

High

638037

UTR1
NAD(+) kinase

1

0

High-throughput

0.480

High

659161

MBR1
Mitochondrial biogenesis regulation protein 1

1

0

High-throughput

0.480

High

735650

SMY1
Kinesin-related protein SMY1

1

0

High-throughput

0.480

High

746743

KPR1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.480

High

793181

AKL1
Serine/threonine-protein kinase AKL1

1

0

High-throughput

0.480

High

793502

MAK5
ATP-dependent RNA helicase MAK5

1

0

High-throughput

0.480

High

823331

YJH0
Inactive deaminase YJL070C

1

0

High-throughput

0.480

High

824494

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.480

High

865509

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

0

High-throughput

0.480

High

917930

MTM1
Mitochondrial carrier protein MTM1

1

0

High-throughput

0.480

High

917931

YG5L
Uncharacterized protein YGR266W

1

0

High-throughput

0.480

High

917958

FMP16
Protein FMP16, mitochondrial

1

0

High-throughput

0.480

High

510663

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.479

High

752534

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.479

High

881393

TOM22
Mitochondrial import receptor subunit TOM22

1

1

High-throughput

0.479

High

382957

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

567697

ACOX
Acyl-coenzyme A oxidase

1

7

High-throughput

0.457

High

617966

DAP2
Dipeptidyl aminopeptidase B

1

1

High-throughput

0.457

High

692518

GYS2
Glycogen [starch] synthase isoform 2

1

1

High-throughput

0.457

High

732036

MLF3
Protein MLF3

1

1

High-throughput

0.457

High

754226

MSN4
Zinc finger protein MSN4

1

1

High-throughput

0.457

High

776413

MNR2
Manganese resistance protein MNR2

1

1

High-throughput

0.457

High

820821

RUXG
Small nuclear ribonucleoprotein G

1

2

High-throughput

0.457

High

824966

VHS2
Protein VHS2

1

1

High-throughput

0.457

High

849621

ALR2
Magnesium transporter ALR2

1

1

High-throughput

0.457

High

916830

MGA1
Protein MGA1

1

1

High-throughput

0.457

High

917941

SNX41
Sorting nexin-41

1

1

High-throughput

0.457

High

917948

FRA1
Putative Xaa-Pro aminopeptidase FRA1

1

1

High-throughput

0.457

High

917937

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.438

High

575558

NMT
Glycylpeptide N-tetradecanoyltransferase

1

0

High-throughput

0.261

Low

613803

SPO7
Sporulation-specific protein SPO7

1

0

High-throughput

0.261

Low

655489

RS3A2
Small ribosomal subunit protein eS1B

1

0

High-throughput

0.261

Low

664321

SSD1
Protein SSD1

1

0

High-throughput

0.261

Low

670305

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.261

Low

703839

LAC1
Ceramide synthase LAC1

1

0

High-throughput

0.261

Low

723623

MLS1
Malate synthase 1

1

0

High-throughput

0.261

Low

740307

PAH1
Phosphatidic acid phosphohydrolase 1

1

0

High-throughput

0.261

Low

740739

SRP40
Suppressor protein SRP40

1

0

High-throughput

0.261

Low

751530

RE104
Meiotic recombination protein REC104

1

0

High-throughput

0.261

Low

754440

NPL4
Nuclear protein localization protein 4

1

0

High-throughput

0.261

Low

760307

BMH2
Protein BMH2

1

0

High-throughput

0.261

Low

782657

PXL1
Paxillin-like protein 1

1

0

High-throughput

0.261

Low

782680

SKG1
Suppressor of lethality of KEX2 GAS1 double null mutant protein 1

1

0

High-throughput

0.261

Low

789807

SOL2
6-phosphogluconolactonase-like protein 2

1

0

High-throughput

0.261

Low

791975

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

0

High-throughput

0.261

Low

797359

ICS2
Increased copper sensitivity protein 2

1

0

High-throughput

0.261

Low

805281

YPT35
Endosomal/vacuolar adapter protein YPT35

1

0

High-throughput

0.261

Low

806268

ADY1
Prospore formation at selected spindle poles protein 1

1

0

High-throughput

0.261

Low

806890

SET5
Histone-lysine N-methyltransferase SET5

1

0

High-throughput

0.261

Low

820883

SIP5
Protein SIP5

1

0

High-throughput

0.261

Low

835522

AZF1
Transcription factor AZF1

1

0

High-throughput

0.261

Low

835542

BUD6
Bud site selection protein 6

1

0

High-throughput

0.261

Low

850404

IGD1
Inhibitor of glycogen debranching 1

1

0

High-throughput

0.261

Low

858277

ARC1
tRNA-aminoacylation cofactor ARC1

1

0

High-throughput

0.261

Low

864265

ALY2
Arrestin-related trafficking adapter 3

1

0

High-throughput

0.261

Low

865135

AVT1
Vacuolar amino acid transporter 1

1

0

High-throughput

0.261

Low

904463

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.261

Low

917928

ORM1
Protein ORM1

1

0

High-throughput

0.261

Low

917929

CENPQ
Inner kinetochore subunit OKP1

1

0

High-throughput

0.261

Low

917932

ZRG17
Protein ZRG17

1

0

High-throughput

0.261

Low

917933

YIF1
Protein transport protein YIF1

1

0

High-throughput

0.261

Low

917934

CWC25
Pre-mRNA-splicing factor CWC25

1

0

High-throughput

0.261

Low

917935

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

High-throughput

0.261

Low

917936

DOS2
Protein DOS2

1

0

High-throughput

0.261

Low

917938

LCL1
Long chronological lifespan protein 1

1

0

High-throughput

0.261

Low

917939

YP077
Uncharacterized protein YPL077C

1

0

High-throughput

0.261

Low

917940

YD042
Uncharacterized protein YDR042C

1

0

High-throughput

0.261

Low

917942

SEG1
Eisosome protein SEG1

1

0

High-throughput

0.261

Low

917943

YM54
Uncharacterized protein YMR196W

1

0

High-throughput

0.261

Low

917944

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.261

Low

917946

HBT1
Protein HBT1

1

0

High-throughput

0.261

Low

917947

TPO1
Polyamine transporter 1

1

0

High-throughput

0.261

Low

917949

ENT4
Epsin-4

1

0

High-throughput

0.261

Low

917950

CMS1
Protein CMS1

1

0

High-throughput

0.261

Low

917951

NBA1
Protein NBA1

1

0

High-throughput

0.261

Low

917952

ALG6
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

0

High-throughput

0.261

Low

917953

BAG7
Rho-GTPase-activating protein BAG7

1

0

High-throughput

0.261

Low

917954

NPC1
NPC intracellular sterol transporter 1-related protein 1

1

0

High-throughput

0.261

Low

917955

SCM3
Protein SCM3

1

0

High-throughput

0.261

Low

917956

WHI5
G1-specific transcriptional repressor WHI5

1

0

High-throughput

0.261

Low

917957

OSH2
Oxysterol-binding protein homolog 2

1

0

High-throughput

0.261

Low

826682

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

917945

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025