Protein: SSN8
RNA polymerase II holoenzyme cyclin-like subunit (Suppressor of RNA polymerase B 11)

Gene: SSN8
Organism: Saccharomyces cerevisiae S288C
Interactions: 81
UniProt ID: P47821

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000411 - positive regulation of transcription by galactose
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0005634 - nucleus
GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

760578

SSN3
Meiotic mRNA stability protein kinase SSN3

15

20

Small-scale

0.987

High

419919

SNF1
Carbon catabolite-derepressing protein kinase

2

0

Small-scale

0.791

High

412476

KIN28
Serine/threonine-protein kinase KIN28

2

20

Small-scale

0.781

High

565686

PHO85
Cyclin-dependent protein kinase PHO85

2

20

Small-scale

0.778

High

814149

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

6

Small-scale

0.747

High

635996

SRB8
Mediator of RNA polymerase II transcription subunit 12

6

7

Small-scale

0.735

High

758000

SSN2
Mediator of RNA polymerase II transcription subunit 13

7

0

Small-scale

0.715

High

548545

GCN2
eIF-2-alpha kinase GCN2

1

4

High-throughput

0.691

High

614718

KC11
Casein kinase I homolog 1

1

8

High-throughput

0.691

High

686855

MED16
Mediator of RNA polymerase II transcription subunit 16

3

0

High-throughput

0.616

High

814143

MED5
Mediator of RNA polymerase II transcription subunit 5

3

0

High-throughput

0.616

High

581371

MED14
Mediator of RNA polymerase II transcription subunit 14

2

2

High-throughput

0.601

High

693933

MED18
Mediator of RNA polymerase II transcription subunit 18

2

0

Small-scale

0.595

High

814153

MED10
Mediator of RNA polymerase II transcription subunit 10

2

2

Small-scale

0.595

High

381559

GAL4
Regulatory protein GAL4

2

3

Small-scale

0.594

High

680046

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

2

1

Small-scale

0.586

High

491741

HSP71
Heat shock protein SSA1

2

8

Small-scale

0.571

High

710269

MED20
Mediator of RNA polymerase II transcription subunit 20

2

0

Small-scale

0.569

High

693597

MED22
Mediator of RNA polymerase II transcription subunit 22

2

0

High-throughput

0.563

High

511903

SSB1
Ribosome-associated molecular chaperone SSB1

2

7

High-throughput

0.552

High

713707

NOT4
General negative regulator of transcription subunit 4

1

0

Small-scale

0.537

High

594341

PP11
Serine/threonine-protein phosphatase PP1-1

1

7

High-throughput

0.536

High

814145

YG5B
Uncharacterized RNA-binding protein YGR250C

1

4

High-throughput

0.536

High

649985

BUD14
Bud site selection protein 14

1

0

High-throughput

0.518

High

409851

NOT2
General negative regulator of transcription subunit 2

1

2

Small-scale

0.515

High

589552

SFL1
Flocculation suppression protein

1

1

Small-scale

0.515

High

389720

CDC25
Cell division control protein 25

1

0

High-throughput

0.513

High

423691

ADR1
Regulatory protein ADR1

1

0

High-throughput

0.513

High

777303

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.513

High

810628

MDV1
Mitochondrial division protein 1

1

5

Small-scale

0.504

High

814138

ASK10
Activator of SKN7 protein 10

1

1

Small-scale

0.504

High

666262

BEM1
Bud emergence protein 1

1

5

High-throughput

0.494

High

730572

MYO3
Myosin-3

1

2

High-throughput

0.494

High

811123

BBC1
Myosin tail region-interacting protein MTI1

1

7

High-throughput

0.494

High

814152

MYO5
Myosin-5

1

2

High-throughput

0.494

High

636156

NOT1
General negative regulator of transcription subunit 1

1

0

Small-scale

0.493

High

697182

PMD1
Negative regulator of sporulation PMD1

1

1

High-throughput

0.489

High

743161

BOB1
Protein BOB1

1

4

High-throughput

0.489

High

814142

MDS3
Negative regulator of sporulation MDS3

1

1

High-throughput

0.489

High

705895

IXR1
Intrastrand cross-link recognition protein

1

4

Small-scale

0.481

High

450098

HSP73
Heat shock protein SSA3

1

8

Small-scale

0.479

High

561887

TUP1
General transcriptional corepressor TUP1

1

5

Small-scale

0.479

High

586319

MED15
Mediator of RNA polymerase II transcription subunit 15

1

1

High-throughput

0.479

High

693553

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.479

High

748108

MED8
Mediator of RNA polymerase II transcription subunit 8

1

1

High-throughput

0.479

High

754281

MED6
Mediator of RNA polymerase II transcription subunit 6

1

2

High-throughput

0.479

High

814156

MED7
Mediator of RNA polymerase II transcription subunit 7

1

3

High-throughput

0.479

High

691824

EI2BB
Translation initiation factor eIF2B subunit beta

1

4

High-throughput

0.464

High

625825

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.458

High

626038

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.458

High

704157

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.458

High

772511

MED3
Mediator of RNA polymerase II transcription subunit 3

1

0

High-throughput

0.458

High

814137

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.458

High

814139

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.458

High

814157

MED2
Mediator of RNA polymerase II transcription subunit 2

1

0

High-throughput

0.458

High

814158

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.458

High

814159

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

814161

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

366553

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.445

High

376841

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

3

High-throughput

0.445

High

494369

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

633362

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

754533

SSZ1
Ribosome-associated complex subunit SSZ1

1

4

High-throughput

0.445

High

768858

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

814150

GCN5
Histone acetyltransferase GCN5

1

19

High-throughput

0.445

High

814141

APC10
Anaphase-promoting complex subunit DOC1

1

4

High-throughput

0.439

High

544043

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.437

High

762738

ACON2
Homocitrate dehydratase, mitochondrial

1

3

High-throughput

0.437

High

784617

BNI1
Protein BNI1

1

1

High-throughput

0.437

High

814140

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.437

High

775628

DJP1
DnaJ-like protein 1

1

3

High-throughput

0.407

High

814147

APP1
Phosphatidate phosphatase APP1

2

0

High-throughput

0.314

High

814148

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.282

High

751388

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.279

Low

814151

GIS4
Protein GIS4

1

0

High-throughput

0.279

Low

814154

PIG1
Serine/threonine-protein phosphatase 1 regulatory subunit PIG1

1

0

High-throughput

0.279

Low

586171

PMA2
Plasma membrane ATPase 2

1

0

High-throughput

0.249

Low

814155

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low

814160

PST1
Cell wall mannoprotein PST1

1

0

High-throughput

0.249

Low

814144

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.238

Low

814146

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024