Protein: TOP3
DNA topoisomerase 3 (EC 5.6.2.1) (DNA topoisomerase III)

Gene: TOP3
Organism: Saccharomyces cerevisiae S288C
Interactions: 30
UniProt ID: P13099

Gene Ontology (top 5):
GO:0000018 - regulation of DNA recombination
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination
GO:0003677 - DNA binding
GO:0003916 - DNA topoisomerase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

560234

SGS1
ATP-dependent helicase SGS1

18

11

Small-scale

0.987

High

560244

RMI1
RecQ-mediated genome instability protein 1

8

0

Small-scale

0.925

High

560242

HFM1
ATP-dependent DNA helicase MER3

1

1

Small-scale

0.740

High

560245

MSH6
DNA mismatch repair protein MSH6

3

1

High-throughput

0.643

High

560235

NSE2
E3 SUMO-protein ligase MMS21

2

0

Small-scale

0.577

High

560236

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

1

3

Small-scale

0.515

High

560248

ESC2
Protein ESC2

1

0

Small-scale

0.480

High

560227

HSP26
Heat shock protein 26

1

1

High-throughput

0.479

High

560229

RCC1
Guanine nucleotide exchange factor SRM1

1

2

High-throughput

0.479

High

560232

SP110
Spindle pole body component 110

1

1

High-throughput

0.479

High

560243

H3
Histone H3

1

2

High-throughput

0.479

High

560249

SMC5
Structural maintenance of chromosomes protein 5

1

2

Small-scale

0.479

High

560252

CMR1
DNA damage-binding protein CMR1

1

2

High-throughput

0.479

High

560230

KPC1
Protein kinase C-like 1

1

0

Small-scale

0.460

High

560233

TFB1
General transcription and DNA repair factor IIH subunit TFB1

1

0

High-throughput

0.458

High

560237

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.458

High

560239

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

560240

RRT5
Regulator of rDNA transcription protein 5

1

0

High-throughput

0.458

High

560246

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

560247

YM04
Abasic site processing protein YMR114C

1

0

High-throughput

0.458

High

560251

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

560238

DUN1
DNA damage response protein kinase DUN1

1

1

High-throughput

0.457

High

392123

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

560231

SIS1
Protein SIS1

1

2

High-throughput

0.445

High

560241

MET5
Sulfite reductase [NADPH] subunit beta

1

1

High-throughput

0.437

High

525780

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

543638

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

560250

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

560228

ATE1
Arginyl-tRNA--protein transferase 1

1

0

Small-scale

0.288

High

560226

KIN2
Serine/threonine-protein kinase KIN2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025