Protein: SMC5
Structural maintenance of chromosomes protein 5

Gene: SMC5
Organism: Saccharomyces cerevisiae S288C
Interactions: 63
UniProt ID: Q08204

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0000725 - recombinational repair
GO:0000781 - chromosome, telomeric region
GO:0003684 - damaged DNA binding
GO:0003697 - single-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

801142

NSE2
E3 SUMO-protein ligase MMS21

12

1

Small-scale

0.983

High

817312

KRE29
DNA repair protein KRE29

10

1

Small-scale

0.972

High

1062336

SMC6
Structural maintenance of chromosomes protein 6

10

17

Small-scale

0.972

High

845910

NSE4
Non-structural maintenance of chromosome element 4

9

11

Small-scale

0.971

High

1051547

NSE3
Non-structural maintenance of chromosome element 3

7

1

Small-scale

0.963

High

1043846

NSE5
Non-structural maintenance of chromosome element 5

5

1

Small-scale

0.925

High

1060818

NSE1
Non-structural maintenance of chromosomes element 1

5

1

Small-scale

0.925

High

826409

MPH1
ATP-dependent DNA helicase MPH1

6

18

Small-scale

0.742

High

805993

RT107
Regulator of Ty1 transposition protein 107

4

14

Small-scale

0.699

High

1062334

SMT3
Ubiquitin-like protein SMT3

4

12

Small-scale

0.685

High

763298

SGS1
ATP-dependent helicase SGS1

3

14

Small-scale

0.661

High

1044795

SCC2
Sister chromatid cohesion protein 2

1

10

High-throughput

0.618

High

815776

SAP1
Protein SAP1

2

9

High-throughput

0.595

High

1046721

SPC24
Kinetochore protein SPC24

2

1

High-throughput

0.595

High

1062338

CENPS
Inner kinetochore subunit MHF1

1

0

Small-scale

0.537

High

817969

IMB4
Importin subunit beta-4

1

5

High-throughput

0.515

High

486334

TBA1
Tubulin alpha-1 chain

1

19

Small-scale

0.501

High

850928

CHA4
Activatory protein CHA4

1

0

High-throughput

0.486

High

1054975

ATG17
Autophagy-related protein 17

1

0

High-throughput

0.486

High

557781

SRS2
ATP-dependent DNA helicase SRS2

1

5

Small-scale

0.481

High

646095

KIN3
Serine/threonine-protein kinase KIN3

1

20

High-throughput

0.481

High

755310

NUF2
Kinetochore protein NUF2

1

9

High-throughput

0.481

High

866073

NNF1
Kinetochore-associated protein NNF1

1

2

High-throughput

0.481

High

1062337

CENPX
Inner kinetochore subunit MHF2

1

0

Small-scale

0.480

High

560249

TOP3
DNA topoisomerase 3

1

2

Small-scale

0.479

High

642080

DPOE
DNA polymerase epsilon catalytic subunit A

1

3

Small-scale

0.479

High

708371

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.479

High

826890

DSN1
Kinetochore-associated protein DSN1

1

4

High-throughput

0.479

High

925103

APJ1
J domain-containing protein APJ1

1

10

High-throughput

0.479

High

1055778

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

665210

DPB2
DNA polymerase epsilon subunit B

1

0

Small-scale

0.458

High

795737

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.458

High

1062332

SLX4
Structure-specific endonuclease subunit SLX4

1

0

Small-scale

0.458

High

386885

TBB
Tubulin beta chain

1

13

Small-scale

0.457

High

393438

HSP82
ATP-dependent molecular chaperone HSP82

1

17

High-throughput

0.445

High

525359

HSP71
Heat shock protein SSA1

1

20

High-throughput

0.445

High

742540

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

804511

SSZ1
Ribosome-associated complex subunit SSZ1

1

15

High-throughput

0.445

High

816440

HSP7E
Heat shock protein SSC3, mitochondrial

1

20

High-throughput

0.445

High

819971

SSB2
Ribosome-associated molecular chaperone SSB2

1

20

High-throughput

0.445

High

916953

VID30
GID complex subunit 1

1

16

High-throughput

0.445

High

809237

END3
Actin cytoskeleton-regulatory complex protein END3

1

6

High-throughput

0.439

High

793634

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

2

High-throughput

0.437

High

792768

EDS1
Transcriptional regulatory protein EDS1

1

0

High-throughput

0.426

High

1044158

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.426

High

1053174

ECM22
Sterol regulatory element-binding protein ECM22

1

0

High-throughput

0.426

High

554973

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.407

High

609245

CLC1
Clathrin light chain

1

4

High-throughput

0.407

High

755183

GCN1
eIF-2-alpha kinase activator GCN1

1

10

High-throughput

0.407

High

813573

MET10
Sulfite reductase [NADPH] flavoprotein component

1

1

High-throughput

0.407

High

1062335

HSP42
Heat shock protein 42

1

3

High-throughput

0.407

High

751558

DHE2
NAD-specific glutamate dehydrogenase

1

0

High-throughput

0.269

Low

654805

URE2
Transcriptional regulator URE2

1

0

High-throughput

0.265

Low

763548

ATG19
Autophagy-related protein 19

1

0

High-throughput

0.265

Low

1039148

MUK1
Protein MUK1

1

0

High-throughput

0.265

Low

1053574

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.265

Low

1062333

HUA2
Protein HUA2

1

0

High-throughput

0.265

Low

814130

HPH2
Protein HPH2

1

0

High-throughput

0.251

Low

643216

KRE5
Killer toxin-resistance protein 5

1

0

High-throughput

0.232

Low

677013

ATG22
Autophagy-related protein 22

1

0

High-throughput

0.232

Low

806247

SVP26
Protein SVP26

1

0

High-throughput

0.232

Low

1060736

YL001
FAS1 domain-containing protein YLR001C

1

0

High-throughput

0.232

Low

1062331

FEX1
Fluoride export protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025