Protein: ERG5
C-22 sterol desaturase ERG5 (EC 1.14.19.41) (Cytochrome P450 61) (Ergosterol biosynthetic protein 5)

Gene: ERG5
Organism: Saccharomyces cerevisiae S288C
Interactions: 32
UniProt ID: P54781

Gene Ontology (top 5):
GO:0000249 - C-22 sterol desaturase (NADPH) activity
GO:0004497 - monooxygenase activity
GO:0005506 - iron ion binding
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

528623

CP51
Lanosterol 14-alpha demethylase CYP51

1

12

High-throughput

0.698

High

636338

ACO1
Acyl-CoA desaturase 1

1

2

High-throughput

0.541

High

668945

ERG6
Sterol 24-C-methyltransferase ERG6

1

1

Small-scale

0.541

High

672171

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

1

Small-scale

0.541

High

916770

ERG25
C-4 methylsterol oxidase ERG25

1

1

Small-scale

0.541

High

932187

TMEDA
Endoplasmic reticulum vesicle protein 25

1

2

High-throughput

0.541

High

932190

ERP1
Protein ERP1

1

2

High-throughput

0.541

High

932193

ERG27
3-keto-steroid reductase ERG27

1

3

Small-scale

0.541

High

439535

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.518

High

737583

ERG1
Squalene epoxidase ERG1

1

0

Small-scale

0.518

High

800449

ERG7
Lanosterol synthase ERG7

1

0

Small-scale

0.518

High

477609

MYO1
Myosin-1

1

1

High-throughput

0.494

High

917363

YGO0
Uncharacterized membrane protein YGL140C

1

0

High-throughput

0.458

High

631981

SRP54
Signal recognition particle subunit SRP54

1

1

High-throughput

0.445

High

795486

ATG8
Autophagy-related protein 8

1

2

High-throughput

0.437

High

817923

IMB4
Importin subunit beta-4

1

1

High-throughput

0.437

High

850139

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.437

High

509675

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

6

High-throughput

0.407

High

524822

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.407

High

545880

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.407

High

819485

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.407

High

865034

TCPQ
T-complex protein 1 subunit theta

1

4

High-throughput

0.407

High

632194

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.282

High

932191

AYT1
Trichothecene 3-O-acetyltransferase

1

0

High-throughput

0.282

High

448776

SNF1
Carbon catabolite-derepressing protein kinase

1

0

High-throughput

0.261

Low

812556

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

922640

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.249

Low

932188

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

932189

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

932194

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.249

Low

924697

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.238

Low

932192

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025