HitPredict

Interactor 1: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Interactor 2: HES4 (Q9HCC6)
Transcription factor HES-4 (hHES4) (Class B basic helix-loop-helix protein 42) (bHLHb42) (Hairy and enhancer of split 4) (bHLH factor Hes4)
Gene: HES4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Hs			1 221
+	Hs
		1047816 TLE1_HUMAN (1-770): 0: 600: 100.00		HES1_HUMAN (1-219): 1.14e-62: 198: 46.76
+	Hs
		1047854 TLE1_HUMAN (1-770): 0: 600: 100.00		HES6_HUMAN (11-219): 1.62e-49: 162: 28.02
+	Hs
		1047888 TLE1_HUMAN (1-770): 0: 600: 100.00		HEY1_HUMAN (2-218): 1.57e-48: 162: 33.19
+	Hs
		1048173 TLE4_HUMAN (1-770): 0: 571: 86.53		HES6_HUMAN (11-219): 1.62e-49: 162: 28.02
+	Mm
		1224205 TLE1_MOUSE (1-770): 0: 573: 96.76		HES6_MOUSE (11-219): 1.32e-45: 152: 26.72
+	Hs
		1048062 TLE3_HUMAN (1-770): 1.2e-180: 537: 77.29		HES6_HUMAN (11-219): 1.62e-49: 162: 28.02
+	Hs
		1047904 TLE2_HUMAN (1-770): 5.33e-153: 465: 64.33		HES1_HUMAN (1-219): 1.14e-62: 198: 46.76
+	Dm
		594684 GROU_DROME (1-770): 3.06e-141: 434: 59.28		ESMB_DROME (25-219): 6.57e-55: 175: 29.76
+	Dm
		594685 GROU_DROME (1-770): 3.06e-141: 434: 59.28		ESMC_DROME (26-219): 4.06e-53: 171: 27.64
+	Dm
		594691 GROU_DROME (1-770): 3.06e-141: 434: 59.28		DPN_DROME (30-218): 1.58e-50: 171: 40.21
+	Dm
		560176 GROU_DROME (1-770): 3.06e-141: 434: 59.28		ESM7_DROME (24-219): 1.59e-49: 161: 27.55
+	Dm
		560201 GROU_DROME (1-770): 3.06e-141: 434: 59.28		ESM8_DROME (28-219): 7.47e-47: 154: 22.92
+	Dm
		594683 GROU_DROME (1-770): 3.06e-141: 434: 59.28		ESM3_DROME (27-219): 1.83e-45: 152: 22.87
+	Dm
		569351 GROU_DROME (1-770): 3.06e-141: 434: 59.28		HAIR_DROME (10-218): 6.25e-44: 151: 35.81
+	Dm
		594686 GROU_DROME (1-770): 3.06e-141: 434: 59.28		ESMD_DROME (28-175): 5.44e-44: 146: 29.94
+	Dm
		594724 GROU_DROME (1-770): 3.06e-141: 434: 59.28		Q9VWX7_DROME (14-154): 1.3e-43: 145: 28.97
+	Dm
		560163 GROU_DROME (1-770): 3.06e-141: 434: 59.28		ESM5_DROME (16-219): 1.1e-40: 138: 22.06
+	Dm
		594713 GROU_DROME (1-770): 3.06e-141: 434: 59.28		Q9VJ16_DROME (21-215): 2.53e-37: 137: 30.99
+	Hs
		65221 TLE5_HUMAN (1-200): 4.92e-91: 285: 64.50		HELT_HUMAN (28-217): 7.69e-40: 138: 28.64
+	Hs
		423 TLE5_HUMAN (1-200): 4.92e-91: 285: 64.50		A0A087WSW0_HUMAN (2-217): 2.14e-38: 136: 23.83