HitPredict

Interactor 1: HAIR (P14003)
Protein hairy
Gene: hry

Interactor 2: GROU (P16371)
Protein groucho (Enhancer of split m9/10 protein) (E(spl)m9/10)
Gene: gro

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	0.60	0.765

Property	Details
Experiments	21343912, 9524128, 9892668, 10433905, 10652276, 11598015, 12154126, 16762837, 17571073, 17898168, 19805071, 8001118, 8649374, 9367988, 9371806, unassigned4
Identification Methods	affinity chromatography technology, pull down, two hybrid, experimental interaction detection
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0007399 - nervous system development GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 337 Dm			1 730
+	Dm
		594691 DPN_DROME (7-298): 1.57e-57: 194: 33.22		GROU_DROME (1-730): 7.6e-174: 517: 100.00
+	Dm
		594684 ESMB_DROME (23-197): 1.47e-48: 163: 27.37		GROU_DROME (1-730): 7.6e-174: 517: 100.00
+	Dm
		594686 ESMD_DROME (17-197): 6.22e-48: 161: 30.60		GROU_DROME (1-730): 7.6e-174: 517: 100.00
+	Dm
		594685 ESMC_DROME (24-192): 9.82e-47: 159: 28.57		GROU_DROME (1-730): 7.6e-174: 517: 100.00
+	Dm
		560176 ESM7_DROME (24-161): 5.04e-43: 148: 33.10		GROU_DROME (1-730): 7.6e-174: 517: 100.00
+	Dm
		560201 ESM8_DROME (24-197): 3.31e-41: 143: 24.58		GROU_DROME (1-730): 7.6e-174: 517: 100.00
+	Dm
		594683 ESM3_DROME (23-142): 1.36e-38: 138: 24.63		GROU_DROME (1-730): 7.6e-174: 517: 100.00
+	Hs
		1047888 HEY1_HUMAN (7-301): 8.1e-54: 180: 21.82		TLE1_HUMAN (1-730): 2.45e-154: 468: 59.95
+	Hs
		1047816 HES1_HUMAN (8-259): 1.55e-53: 179: 33.33		TLE1_HUMAN (1-730): 2.45e-154: 468: 59.95
+	Hs
		1047904 HES1_HUMAN (8-259): 1.55e-53: 179: 33.33		TLE2_HUMAN (1-730): 3.36e-141: 433: 55.61
+	Hs
		1048173 HES6_HUMAN (27-226): 3.41e-40: 142: 23.04		TLE4_HUMAN (1-730): 1.65e-154: 469: 60.36
+	Hs
		1047854 HES6_HUMAN (27-226): 3.41e-40: 142: 23.04		TLE1_HUMAN (1-730): 2.45e-154: 468: 59.95
+	Hs
		1047867 HES4_HUMAN (9-218): 2.82e-37: 134: 33.33		TLE1_HUMAN (1-730): 2.45e-154: 468: 59.95
+	Mm
		1224205 HES6_MOUSE (14-226): 1.93e-39: 140: 20.74		TLE1_MOUSE (1-730): 4.49e-149: 455: 59.44
+	Hs
		1048062 HES6_HUMAN (27-226): 3.41e-40: 142: 23.04		TLE3_HUMAN (1-730): 1.79e-144: 443: 56.89
+	Hs
		154968 BHE40_HUMAN (24-302): 8.18e-51: 175: 17.49		TLE5_HUMAN (1-197): 4.9e-83: 263: 49.51
+	Hs
		65221 HELT_HUMAN (27-235): 4.18e-41: 145: 23.85		TLE5_HUMAN (1-197): 4.9e-83: 263: 49.51
+	Hs
		1061823 HES6_HUMAN (27-226): 3.41e-40: 142: 23.04		TLE5_HUMAN (1-197): 4.9e-83: 263: 49.51
+	Rn
		205554 BHE40_RAT (24-302): 4.7e-53: 181: 17.49		GBB2_RAT (506-728): 6.31e-51: 182: 17.39
+	Hs
		154956 BHE40_HUMAN (24-302): 8.18e-51: 175: 17.49		GBB2_HUMAN (506-728): 6.31e-51: 182: 17.39