HitPredict

Interactor 1: NCPR (P16435)
NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4)
Gene: POR

Interactor 2: CP2CJ (P33261)
Cytochrome P450 2C19 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase)
Gene: CYP2C19

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	9398194, 15680923
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Flavodoxin_1~p450
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0006805 - xenobiotic metabolic process GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 677 Hs			1 490
+	Hs
		514663 NCPR_HUMAN (1-677): 0: 975: 100.00		CP2C9_HUMAN (20-490): 0: 565: 91.72
+	Hs
		513728 NCPR_HUMAN (1-677): 0: 975: 100.00		CP2A6_HUMAN (3-489): 0: 530: 51.34
+	Hs
		398437 NCPR_HUMAN (1-677): 0: 975: 100.00		CP2E1_HUMAN (5-489): 0: 523: 57.53
+	Hs
		443995 NCPR_HUMAN (1-677): 0: 975: 100.00		CP3A4_HUMAN (1-487): 6.65e-151: 441: 22.76
+	Hs
		496154 NCPR_HUMAN (1-677): 0: 975: 100.00		CP2D6_HUMAN (5-489): 2.97e-150: 439: 39.59
+	Hs
		398427 NCPR_HUMAN (1-677): 0: 975: 100.00		CP1A2_HUMAN (3-472): 5.6e-56: 196: 28.89