HitPredict

Interactor 1: ARHG6 (Q15052)
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Gene: ARHGEF6

Interactor 2: SPN90 (Q9NZQ3)
NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein)
Gene: NCKIPSD

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1, RhoGEF~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 776 Hs			1 722
+	Hs
		1049739 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		SPN90_HUMAN (1-722): 0: 1137: 100.00
+	Hs
		1078920 ITSN1_HUMAN (18-575): 4.42e-86: 300: 15.88		SPN90_HUMAN (1-722): 0: 1137: 100.00
+	Hs
		1349276 ITSN2_HUMAN (17-575): 4.43e-83: 291: 16.67		SPN90_HUMAN (1-722): 0: 1137: 100.00