HitPredict

Interactor 1: LTBP2 (Q14767)
Latent-transforming growth factor beta-binding protein 2 (LTBP-2)
Gene: LTBP2

Interactor 2: EGFL7 (Q9UHF1)
Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)
Gene: EGFL7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	EGF~FXa_inhibition, EGF_CA~FXa_inhibition
Common GO terms	GO:0005509 - calcium ion binding GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1821 Hs			1 273
+	Hs
		1132132 LTBP2_HUMAN (1-1821): 0: 696: 100.00		EGFL8_HUMAN (14-273): 5.92e-38: 136: 34.44
+	Mm
		148549 LTBP2_MOUSE (1-1821): 0: 636: 78.84		FBLN5_MOUSE (70-176): 1.06e-15: 78.2: 30.17
+	Hs
		857580 NOTC1_HUMAN (172-1495): 1.28e-82: 305: 15.09		EGFL7_HUMAN (1-273): 3.18e-41: 144: 100.00
+	Mm
		728041 NOTC4_MOUSE (93-1360): 6.68e-68: 257: 13.69		EGFL7_MOUSE (1-272): 1.08e-38: 138: 78.10
+	Hs
		857407 NOTC1_HUMAN (172-1495): 1.28e-82: 305: 15.09		JAG1_HUMAN (66-168): 2.85e-10: 62.4: 28.57
+	Hs
		857370 NOTC1_HUMAN (172-1495): 1.28e-82: 305: 15.09		NOTC1_HUMAN (85-183): 3.37e-09: 59.4: 21.57
+	Hs
		565088 FBN1_HUMAN (648-1820): 1.81e-64: 246: 20.05		CSPG2_HUMAN (97-176): 3.7e-15: 77.5: 27.91
+	Hs
		1294393 FRAS1_HUMAN (373-1351): 7.93e-41: 168: 13.24		EGFL7_HUMAN (1-273): 3.18e-41: 144: 100.00
+	Hs
		772346 FBN2_HUMAN (274-1116): 2.17e-40: 167: 16.38		EGFL7_HUMAN (1-273): 3.18e-41: 144: 100.00
+	Dm
		95089 NOTCH_DROME (201-1277): 1.18e-58: 226: 13.61		E1JHA6_DROME (2-138): 3.41e-13: 71.4: 12.93
+	Hs
		1047772 NOTC2_HUMAN (1225-1821): 1.55e-35: 151: 13.10		EGFL7_HUMAN (1-273): 3.18e-41: 144: 100.00
+	Mm
		204911 NOTC2_MOUSE (1220-1821): 1.24e-35: 151: 13.49		EGFL7_MOUSE (1-272): 1.08e-38: 138: 78.10
+	Dm
		451712 NOTCH_DROME (201-1277): 1.18e-58: 226: 13.61		NOTCH_DROME (68-172): 2.45e-09: 59.8: 22.32
+	Dm
		451716 NOTCH_DROME (201-1277): 1.18e-58: 226: 13.61		DL_DROME (53-168): 3.56e-09: 59: 25.58
+	Mm
		1032094 NOTC1_MOUSE (207-1018): 1.01e-29: 132: 10.27		EGFL7_MOUSE (1-272): 1.08e-38: 138: 78.10
+	Hs
		317563 NOTC2_HUMAN (1225-1821): 1.55e-35: 151: 13.10		SLIT2_HUMAN (59-271): 1.73e-25: 107: 12.29
+	Hs
		452091 NOTC2_HUMAN (1225-1821): 1.55e-35: 151: 13.10		PROS_HUMAN (24-201): 7.76e-19: 87.9: 19.37
+	Hs
		1047591 NOTC2_HUMAN (1225-1821): 1.55e-35: 151: 13.10		NPNT_HUMAN (80-173): 3.93e-11: 64.8: 32.35
+	Hs
		1008015 NOTC2_HUMAN (1225-1821): 1.55e-35: 151: 13.10		JAG1_HUMAN (66-168): 2.85e-10: 62.4: 28.57
+	Hs
		857423 NOTC2_HUMAN (1225-1821): 1.55e-35: 151: 13.10		NOTC1_HUMAN (85-183): 3.37e-09: 59.4: 21.57