HitPredict

Interactor 1: LHX4 (Q969G2)
LIM/homeobox protein Lhx4 (LIM homeobox protein 4)
Gene: LHX4

Interactor 2: ISL2 (Q96A47)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.947

Property	Details
Experiments	24981860, 26186194, 28514442, 33961781, 35140242, 27820671
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain, LIM~LIM
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:1990837 - sequence-specific double-stranded DNA binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 390 Hs			1 359
+	Hs
		899929 LHX4_HUMAN (1-390): 1.1e-107: 323: 100.00		ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91
+	Mm
		864805 LHX4_MOUSE (1-390): 8.46e-108: 323: 98.97		ISL2_MOUSE (1-359): 3.88e-85: 263: 98.61
+	Hs
		899935 LHX3_HUMAN (1-390): 1.94e-87: 271: 60.25		ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91
+	Hs
		1283500 LHX3_HUMAN (1-390): 1.94e-87: 271: 60.25		ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00
+	Mm
		839895 LHX3_MOUSE (6-390): 7.2e-82: 257: 60.41		ISL1_MOUSE (14-358): 6.97e-87: 268: 73.91
+	Hs
		903763 LHX4_HUMAN (1-390): 1.1e-107: 323: 100.00		LMO4_HUMAN (15-165): 1.69e-54: 178: 38.13
+	Hs
		899927 LMX1A_HUMAN (2-347): 2.28e-68: 222: 27.90		ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91
+	Dm
		114751 M9PD53_DROME (26-384): 1.23e-68: 227: 49.59		P92031_DROME (6-345): 6.08e-63: 211: 51.61
+	Dm
		1368258 Q9VJ00_DROME (26-384): 2.84e-68: 225: 49.59		Q9VJ37_DROME (6-345): 3.2e-63: 212: 52.15
+	Dm
		112552 M9NCY1_DROME (26-384): 5.18e-69: 224: 49.59		Q9VJ37_DROME (6-345): 3.2e-63: 212: 52.15
+	Hs
		1251418 LHX4_HUMAN (1-390): 1.1e-107: 323: 100.00		LMO3_HUMAN (27-148): 1.53e-26: 104: 40.16
+	Hs
		1281195 LHX4_HUMAN (1-390): 1.1e-107: 323: 100.00		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Hs
		1255791 LHX3_HUMAN (1-390): 1.94e-87: 271: 60.25		LMX1A_HUMAN (7-83): 2.7e-17: 84.3: 20.78
+	Hs
		822689 LHX3_HUMAN (1-390): 1.94e-87: 271: 60.25		LHX1_HUMAN (7-81): 9.53e-14: 73.9: 19.74
+	Hs
		1251463 LHX5_HUMAN (29-388): 8.66e-64: 210: 32.68		LMO3_HUMAN (27-148): 1.53e-26: 104: 40.16
+	Hs
		238113 LMX1B_HUMAN (10-347): 2.11e-62: 207: 28.00		LMO3_HUMAN (27-148): 1.53e-26: 104: 40.16
+	Hs
		238099 LMX1B_HUMAN (10-347): 2.11e-62: 207: 28.00		RBTN1_HUMAN (27-143): 3.27e-26: 103: 40.83
+	Hs
		1255789 LMX1A_HUMAN (2-347): 2.28e-68: 222: 27.90		LMX1A_HUMAN (7-83): 2.7e-17: 84.3: 20.78