HitPredict

Interactor 1: ASH2L (Q9UBL3)
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)
Gene: ASH2L

Interactor 2: SET1B (Q9UPS6)
Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)
Gene: SETD1B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.978

Property	Details
Experiments	26496610, 27563068, 17998332, 26886794, 24981860, 34079125, 33961781, 23508102, 37974198, 20305087
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SET~SPRY
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0048188 - Set1C/COMPASS complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 628 Hs			1 1966
+	Hs
		1354085 ASH2L_HUMAN (1-628): 0: 790: 100.00		KMT2B_HUMAN (1069-1966): 4.68e-71: 268: 21.69
+	Hs
		975339 ASH2L_HUMAN (1-628): 0: 790: 100.00		KMT2A_HUMAN (1173-1966): 2.68e-66: 252: 21.73
+	Hs
		1080434 ASH2L_HUMAN (1-628): 0: 790: 100.00		EZH2_HUMAN (1464-1949): 9.8e-64: 235: 15.84
+	Hs
		1243848 ASH2L_HUMAN (1-628): 0: 790: 100.00		KMT2C_HUMAN (1759-1966): 1.32e-58: 227: 37.04
+	Hs
		165730 ASH2L_HUMAN (1-628): 0: 790: 100.00		SET1A_HUMAN (409-1966): 1e-54: 214: 22.13
+	Mm
		1207211 ASH2L_MOUSE (12-628): 0: 768: 96.11		KMT2C_MOUSE (1759-1966): 6.65e-58: 225: 36.57
+	Hs
		152695 ASH2L_HUMAN (1-628): 0: 790: 100.00		KMT2D_HUMAN (1826-1966): 3.07e-17: 91.3: 46.85
+	Dm
		1215700 ASH2_DROME (87-621): 0: 541: 48.07		TRR_DROME (1759-1966): 1.74e-65: 249: 35.62
+	Sp
		223858 ASH2_SCHPO (60-628): 3.47e-171: 504: 23.60		SET1_SCHPO (1461-1966): 2.02e-73: 267: 24.62
+	Dm
		594805 ASH2_DROME (87-621): 0: 541: 48.07		TRX_DROME (623-1966): 6.2e-59: 228: 12.77
+	Dm
		1129071 ASH2_DROME (87-621): 0: 541: 48.07		SET1_DROME (30-197): 5.94e-53: 208: 38.60
+	Hs
		198028 PHF1_HUMAN (85-398): 6.02e-85: 278: 14.91		EZH1_HUMAN (1610-1949): 1.07e-66: 243: 19.54
+	Hs
		203703 PHF19_HUMAN (85-327): 3.91e-83: 274: 16.80		SUV91_HUMAN (1686-1965): 2.95e-70: 244: 17.93
+	Hs
		1134176 PHF19_HUMAN (85-327): 3.91e-83: 274: 16.80		EZH1_HUMAN (1610-1949): 1.07e-66: 243: 19.54
+	Hs
		197991 PHF1_HUMAN (85-398): 6.02e-85: 278: 14.91		EZH2_HUMAN (1464-1949): 9.8e-64: 235: 15.84
+	Hs
		203819 MTF2_HUMAN (83-337): 3.42e-81: 269: 15.53		SUV91_HUMAN (1686-1965): 2.95e-70: 244: 17.93
+	Hs
		1134190 PHF19_HUMAN (85-327): 3.91e-83: 274: 16.80		SUV92_HUMAN (1717-1966): 9.97e-68: 237: 20.29
+	Mm
		1142302 PHF1_MOUSE (85-398): 2.25e-82: 271: 15.27		EZH2_MOUSE (1461-1949): 4.71e-65: 239: 15.18
+	Hs
		1080024 PHF19_HUMAN (85-327): 3.91e-83: 274: 16.80		EZH2_HUMAN (1464-1949): 9.8e-64: 235: 15.84
+	Hs
		1080516 MTF2_HUMAN (83-337): 3.42e-81: 269: 15.53		EZH2_HUMAN (1464-1949): 9.8e-64: 235: 15.84