HitPredict

Interactor 1: WIPF1 (O43516)
WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein)
Gene: WIPF1

Interactor 2: HCLS1 (P14317)
Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75)
Gene: HCLS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	21398607
Identification Methods	pull down, far western blotting
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 503 Hs			1 486
+	Hs
		219553 WIPF1_HUMAN (1-503): 1.73e-30: 126: 100.00		SRC8_HUMAN (1-486): 1.09e-127: 383: 39.86
+	Hs
		1124751 ASAP1_HUMAN (12-437): 3.97e-27: 117: 19.59		SRC8_HUMAN (1-486): 1.09e-127: 383: 39.86
+	Mm
		1221188 WIPF1_MOUSE (1-503): 1.09e-25: 111: 85.52		SRC8_MOUSE (1-486): 8.97e-129: 386: 40.88
+	Hs
		571698 PCLO_HUMAN (19-424): 2.36e-09: 62.6: 12.20		HCLS1_HUMAN (1-486): 1.88e-143: 422: 100.00
+	Hs
		619131 ASAP1_HUMAN (12-437): 3.97e-27: 117: 19.59		PLCG1_HUMAN (55-485): 3.93e-41: 159: 17.41
+	Hs
		1060676 SOS1_HUMAN (134-459): 2.54e-23: 106: 16.77		SPTN1_HUMAN (32-486): 2.51e-44: 169: 14.41
+	Mm
		1223508 SOS1_MOUSE (134-459): 1.69e-22: 103: 21.47		PLCG1_MOUSE (55-485): 3.9e-43: 165: 18.30
+	Hs
		619037 SOS1_HUMAN (134-459): 2.54e-23: 106: 16.77		PLCG1_HUMAN (55-485): 3.93e-41: 159: 17.41
+	Hs
		635521 SOS1_HUMAN (134-459): 2.54e-23: 106: 16.77		NEBU_HUMAN (145-485): 2.78e-35: 142: 16.03
+	Hs
		1408400 ASAP1_HUMAN (12-437): 3.97e-27: 117: 19.59		SH3G2_HUMAN (180-485): 1.02e-31: 126: 15.74
+	Rn
		93231 D4A3T0_RAT (134-459): 4.96e-23: 105: 19.94		PACN1_RAT (138-485): 8.35e-35: 137: 15.82
+	Hs
		635544 TITIN_HUMAN (144-368): 6.93e-11: 67.5: 18.33		NEBU_HUMAN (145-485): 2.78e-35: 142: 16.03
+	Hs
		1045040 PRB3_HUMAN (269-503): 8.57e-15: 77.6: 17.07		SH3G1_HUMAN (242-485): 1.26e-31: 126: 19.26
+	Hs
		219564 WIPF1_HUMAN (1-503): 1.73e-30: 126: 100.00		ABI2_HUMAN (269-485): 3.96e-14: 76.5: 22.22
+	Hs
		1368310 ASAP1_HUMAN (12-437): 3.97e-27: 117: 19.59		STAM1_HUMAN (358-482): 2.01e-13: 74.5: 21.60
+	Ce
		73269 G5EBN5_CAEEL (64-481): 3.48e-11: 68.2: 15.77		SH3GH_CAEEL (241-485): 1.58e-29: 121: 14.69
+	Hs
		250282 PHLB1_HUMAN (128-452): 2.91e-23: 105: 23.14		VINEX_HUMAN (344-485): 7.06e-14: 76.2: 18.75
+	Hs
		250300 WIPF2_HUMAN (10-503): 6.64e-24: 105: 32.60		VINEX_HUMAN (344-485): 7.06e-14: 76.2: 18.75
+	Hs
		1060677 SOS1_HUMAN (134-459): 2.54e-23: 106: 16.77		ITSN1_HUMAN (339-485): 2.85e-11: 68.1: 20.25
+	Hs
		176266 SYNJ2_HUMAN (11-464): 2.12e-21: 100: 15.09		ITSN1_HUMAN (339-485): 2.85e-11: 68.1: 20.25