HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: ARHGH (Q96PE2)
Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4)
Gene: ARHGEF17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	RhoGEF~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 2063
+	Hs
		594071 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		ARHG2_HUMAN (938-1740): 2.49e-105: 364: 15.50
+	Hs
		222084 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		ARHG6_HUMAN (1070-1382): 7.72e-70: 253: 21.20
+	Hs
		594104 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		ECT2_HUMAN (984-1451): 4.23e-72: 263: 21.08
+	Hs
		594004 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		ARHG6_HUMAN (1070-1382): 7.72e-70: 253: 21.20
+	Hs
		1154182 ITSN2_HUMAN (5-273): 6.53e-36: 141: 19.27		ITSN1_HUMAN (565-1518): 1.17e-99: 359: 14.74
+	Hs
		1453434 ITSN2_HUMAN (5-273): 6.53e-36: 141: 19.27		ITSN2_HUMAN (587-1518): 1.18e-93: 339: 13.15
+	Hs
		1154087 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		ITSN1_HUMAN (565-1518): 1.17e-99: 359: 14.74
+	Hs
		699767 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		ITSN1_HUMAN (565-1518): 1.17e-99: 359: 14.74
+	Hs
		540015 GRAP_HUMAN (5-169): 9.9e-28: 110: 15.74		BCR_HUMAN (688-1499): 1.68e-94: 338: 19.82
+	Hs
		539948 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		BCR_HUMAN (688-1499): 1.68e-94: 338: 19.82
+	Hs
		136273 P85B_HUMAN (21-380): 2.06e-23: 104: 12.80		BCR_HUMAN (688-1499): 1.68e-94: 338: 19.82
+	Hs
		473357 HCK_HUMAN (2-184): 1.58e-23: 103: 21.74		BCR_HUMAN (688-1499): 1.68e-94: 338: 19.82
+	Hs
		584478 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		VAV_HUMAN (973-1660): 2.17e-95: 331: 14.77
+	Hs
		299586 ITSN2_HUMAN (5-273): 6.53e-36: 141: 19.27		TRIO_HUMAN (1051-1752): 1.63e-76: 286: 15.46
+	Hs
		174220 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		ARHGA_HUMAN (1727-2021): 2.62e-81: 298: 24.75
+	Hs
		1154138 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		PREX1_HUMAN (1039-1418): 2.96e-76: 284: 23.93
+	Hs
		699788 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		FGD2_HUMAN (964-1421): 1.17e-82: 288: 18.34
+	Hs
		699860 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		ECT2_HUMAN (984-1451): 4.23e-72: 263: 21.08
+	Hs
		699889 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		VAV3_HUMAN (1046-1323): 6.44e-18: 92.8: 27.72