HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: SOCS4 (Q8WXH5)
Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)
Gene: SOCS4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17997974
Identification Methods	isothermal titration calorimetry
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0019221 - cytokine-mediated signaling pathway GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Hs			1 440
+	Mm
		236702 JAK2_MOUSE (1-1129): 0: 1103: 93.89		SOCS5_MOUSE (7-436): 1.24e-130: 389: 52.26
+	Hs
		253386 JAK2_HUMAN (1-1132): 0: 1116: 100.00		CISH_HUMAN (212-425): 5.47e-51: 174: 22.93
+	Rn
		108118 JAK2_RAT (1-1131): 0: 1119: 94.70		G3V6B4_RAT (260-425): 5.97e-46: 159: 22.29
+	Hs
		253283 JAK2_HUMAN (1-1132): 0: 1116: 100.00		SRC_HUMAN (134-389): 9.3e-44: 162: 12.50
+	Hs
		193159 JAK2_HUMAN (1-1132): 0: 1116: 100.00		SOCS1_HUMAN (260-425): 3.01e-46: 160: 22.29
+	Hs
		253271 JAK2_HUMAN (1-1132): 0: 1116: 100.00		FYN_HUMAN (201-387): 5.13e-42: 157: 17.53
+	Mm
		1048195 JAK2_MOUSE (1-1129): 0: 1103: 93.89		YES_MOUSE (151-429): 2.77e-45: 166: 15.39
+	Mm
		431356 JAK2_MOUSE (1-1129): 0: 1103: 93.89		SRC_MOUSE (171-389): 7.65e-45: 165: 12.45
+	Hs
		253273 JAK2_HUMAN (1-1132): 0: 1116: 100.00		LYN_HUMAN (163-433): 8.16e-40: 151: 16.43
+	Mm
		205433 JAK2_MOUSE (1-1129): 0: 1103: 93.89		SOCS1_MOUSE (260-425): 6.64e-46: 159: 22.29
+	Hs
		155885 JAK2_HUMAN (1-1132): 0: 1116: 100.00		SOCS3_HUMAN (250-422): 1.63e-37: 138: 20.09
+	Mm
		205468 JAK2_MOUSE (1-1129): 0: 1103: 93.89		SOCS3_MOUSE (250-422): 8.03e-39: 141: 20.09
+	Hs
		253291 JAK2_HUMAN (1-1132): 0: 1116: 100.00		PLCG2_HUMAN (258-399): 9.79e-23: 103: 18.88
+	Hs
		253293 JAK2_HUMAN (1-1132): 0: 1116: 100.00		PLCG1_HUMAN (271-379): 4.45e-22: 101: 18.18
+	Hs
		253301 JAK2_HUMAN (1-1132): 0: 1116: 100.00		P85A_HUMAN (175-392): 1.31e-15: 81: 14.66
+	Mm
		686971 JAK2_MOUSE (1-1129): 0: 1103: 93.89		P85A_MOUSE (175-392): 1.74e-15: 80.6: 14.66
+	Hs
		155081 TYK2_HUMAN (38-1132): 0: 861: 35.49		SOCS2_HUMAN (234-425): 1.65e-46: 160: 25.85
+	Hs
		193213 TYK2_HUMAN (38-1132): 0: 861: 35.49		SOCS1_HUMAN (260-425): 3.01e-46: 160: 22.29
+	Hs
		440395 TYK2_HUMAN (38-1132): 0: 861: 35.49		FYN_HUMAN (201-387): 5.13e-42: 157: 17.53
+	Hs
		463362 TYK2_HUMAN (38-1132): 0: 861: 35.49		LYN_HUMAN (163-433): 8.16e-40: 151: 16.43