HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.979

Property	Details
Experiments	24438103, 10882725, 10421843, 9344848, 11314018, 19543316, 22342841, 15514089, 14517242, 29752723, 36112698, 24354892
Identification Methods	enzymatic study, affinity chromatography technology, two hybrid, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0009898 - cytoplasmic side of plasma membrane GO:0019221 - cytokine-mediated signaling pathway GO:0035556 - intracellular signal transduction GO:0045597 - positive regulation of cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1132
+	Hs
		253369 SOCS4_HUMAN (16-221): 1.21e-53: 179: 20.29		JAK2_HUMAN (1-1132): 0: 1116: 100.00
+	Mm
		205468 SOCS3_MOUSE (1-225): 1.02e-54: 176: 96.89		JAK2_MOUSE (1-1129): 0: 1103: 93.89
+	Mm
		1048195 YES_MOUSE (30-223): 1.21e-50: 174: 15.11		JAK2_MOUSE (1-1129): 0: 1103: 93.89
+	Hs
		155888 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		ABL1_HUMAN (837-1126): 3.25e-96: 333: 33.68
+	Hs
		155151 SOCS7_HUMAN (13-221): 6.01e-51: 175: 24.17		YES_HUMAN (805-1125): 2.21e-97: 322: 27.02
+	Hs
		155896 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		YES_HUMAN (805-1125): 2.21e-97: 322: 27.02
+	Hs
		155893 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		LCK_HUMAN (827-1132): 1.51e-97: 321: 30.62
+	Hs
		462945 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		YES_HUMAN (805-1125): 2.21e-97: 322: 27.02
+	Hs
		439905 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		LCK_HUMAN (827-1132): 1.51e-97: 321: 30.62
+	Hs
		440300 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		FYN_HUMAN (800-1125): 1.21e-96: 319: 27.52
+	Hs
		155925 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		BLK_HUMAN (795-1124): 4.07e-93: 309: 29.52
+	Hs
		462946 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		LYN_HUMAN (807-1132): 4.35e-93: 309: 30.89
+	Hs
		462953 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		FGR_HUMAN (810-1131): 5.61e-91: 304: 26.32
+	Hs
		155941 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		PTK6_HUMAN (839-1126): 1.44e-87: 292: 29.07
+	Hs
		155926 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		JAK3_HUMAN (545-829): 4.69e-60: 227: 20.65
+	Hs
		155911 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		JAK1_HUMAN (793-1131): 9.56e-37: 153: 18.44
+	Mm
		73018 SOCS3_MOUSE (1-225): 1.02e-54: 176: 96.89		B1ASP2_MOUSE (830-1131): 3.32e-36: 151: 19.30
+	Hs
		1060799 SOCS4_HUMAN (16-221): 1.21e-53: 179: 20.29		ACK1_HUMAN (518-822): 4.53e-17: 89: 26.97
+	Hs
		155946 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		ERBB4_HUMAN (521-808): 2.54e-18: 93.2: 25.25
+	Hs
		462961 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		FGFR1_HUMAN (545-838): 5.98e-13: 75.5: 22.57