HitPredict

Interactor 1: MMP1 (P03956)
Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]
Gene: MMP1

Interactor 2: CO1A2 (P08123)
Collagen alpha-2(I) chain (Alpha-2 type I collagen)
Gene: COL1A2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19010413
Identification Methods	protease assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 469 Hs			1 1366
+	Hs
		465927 MMP3_HUMAN (1-466): 0: 629: 52.93		CO1A2_HUMAN (1-1366): 0: 739: 100.00
+	Hs
		465939 MMP8_HUMAN (16-467): 0: 604: 58.15		CO1A2_HUMAN (1-1366): 0: 739: 100.00
+	Hs
		465954 MMP16_HUMAN (1-466): 0: 544: 33.52		CO1A2_HUMAN (1-1366): 0: 739: 100.00
+	Hs
		465953 MMP15_HUMAN (34-468): 0: 528: 33.07		CO1A2_HUMAN (1-1366): 0: 739: 100.00
+	Hs
		465926 MMP2_HUMAN (6-206): 3.1e-83: 271: 41.91		CO1A2_HUMAN (1-1366): 0: 739: 100.00
+	Hs
		465931 MMP9_HUMAN (20-206): 5.22e-71: 240: 48.13		CO1A2_HUMAN (1-1366): 0: 739: 100.00
+	Hs
		384090 MMP2_HUMAN (6-206): 3.1e-83: 271: 41.91		CO1A1_HUMAN (14-1018): 1.23e-93: 334: 43.06
+	Hs
		469662 MMP2_HUMAN (6-206): 3.1e-83: 271: 41.91		CO5A1_HUMAN (11-863): 9.04e-61: 232: 42.22
+	Hs
		575778 MMP9_HUMAN (20-206): 5.22e-71: 240: 48.13		CO5A1_HUMAN (11-863): 9.04e-61: 232: 42.22
+	Hs
		384297 MMP2_HUMAN (6-206): 3.1e-83: 271: 41.91		CO4A1_HUMAN (520-1182): 1.05e-43: 176: 33.20
+	Hs
		384231 MMP2_HUMAN (6-206): 3.1e-83: 271: 41.91		CO2A1_HUMAN (713-1173): 8.99e-38: 157: 33.39
+	Hs
		384300 MMP9_HUMAN (20-206): 5.22e-71: 240: 48.13		CO4A1_HUMAN (520-1182): 1.05e-43: 176: 33.20
+	Hs
		469690 MMP2_HUMAN (6-206): 3.1e-83: 271: 41.91		COMA1_HUMAN (6-539): 1.12e-30: 134: 35.52
+	Hs
		384239 MMP9_HUMAN (20-206): 5.22e-71: 240: 48.13		CO2A1_HUMAN (713-1173): 8.99e-38: 157: 33.39
+	Hs
		469654 MMP2_HUMAN (6-206): 3.1e-83: 271: 41.91		CO4A2_HUMAN (1-294): 1.63e-27: 123: 28.23
+	Hs
		469674 MMP2_HUMAN (6-206): 3.1e-83: 271: 41.91		COGA1_HUMAN (3-638): 1.12e-26: 121: 33.55
+	Hs
		469677 MMP2_HUMAN (6-206): 3.1e-83: 271: 41.91		CO4A6_HUMAN (1-291): 9.11e-27: 121: 30.51
+	Hs
		438023 MMP2_HUMAN (6-206): 3.1e-83: 271: 41.91		CO5A2_HUMAN (806-1172): 2.29e-25: 116: 29.96
+	Hs
		469655 MMP2_HUMAN (6-206): 3.1e-83: 271: 41.91		COBA1_HUMAN (815-1170): 4.73e-23: 109: 26.54
+	Hs
		471579 MMP9_HUMAN (20-206): 5.22e-71: 240: 48.13		CO4A2_HUMAN (1-294): 1.63e-27: 123: 28.23