HitPredict

Interactor 1: CO1A2 (P08123)
Collagen alpha-2(I) chain (Alpha-2 type I collagen)
Gene: COL1A2

Interactor 2: MMP16 (P51512)
Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)
Gene: MMP16

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19010413
Identification Methods	protease assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001501 - skeletal system development GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1366 Hs			1 607
+	Hs
		465951 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP14_HUMAN (30-607): 0: 694: 54.75
+	Hs
		465953 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP15_HUMAN (34-607): 0: 682: 52.24
+	Hs
		465927 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP3_HUMAN (26-532): 0: 560: 34.42
+	Hs
		399260 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP1_HUMAN (30-535): 0: 544: 35.16
+	Hs
		465939 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP8_HUMAN (31-532): 0: 537: 34.71
+	Hs
		465926 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP2_HUMAN (30-231): 1.31e-77: 260: 36.14
+	Hs
		465931 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP9_HUMAN (23-231): 1.53e-62: 221: 36.19
+	Hs
		384090 CO1A1_HUMAN (14-1018): 1.23e-93: 334: 43.06		MMP2_HUMAN (30-231): 1.31e-77: 260: 36.14
+	Hs
		469662 CO5A1_HUMAN (11-863): 9.04e-61: 232: 42.22		MMP2_HUMAN (30-231): 1.31e-77: 260: 36.14
+	Hs
		575778 CO5A1_HUMAN (11-863): 9.04e-61: 232: 42.22		MMP9_HUMAN (23-231): 1.53e-62: 221: 36.19
+	Hs
		384297 CO4A1_HUMAN (520-1182): 1.05e-43: 176: 33.20		MMP2_HUMAN (30-231): 1.31e-77: 260: 36.14
+	Hs
		384231 CO2A1_HUMAN (713-1173): 8.99e-38: 157: 33.39		MMP2_HUMAN (30-231): 1.31e-77: 260: 36.14
+	Hs
		384300 CO4A1_HUMAN (520-1182): 1.05e-43: 176: 33.20		MMP9_HUMAN (23-231): 1.53e-62: 221: 36.19
+	Hs
		469690 COMA1_HUMAN (6-539): 1.12e-30: 134: 35.52		MMP2_HUMAN (30-231): 1.31e-77: 260: 36.14
+	Hs
		469654 CO4A2_HUMAN (1-294): 1.63e-27: 123: 28.23		MMP2_HUMAN (30-231): 1.31e-77: 260: 36.14
+	Hs
		469674 COGA1_HUMAN (3-638): 1.12e-26: 121: 33.55		MMP2_HUMAN (30-231): 1.31e-77: 260: 36.14
+	Hs
		469677 CO4A6_HUMAN (1-291): 9.11e-27: 121: 30.51		MMP2_HUMAN (30-231): 1.31e-77: 260: 36.14
+	Hs
		384239 CO2A1_HUMAN (713-1173): 8.99e-38: 157: 33.39		MMP9_HUMAN (23-231): 1.53e-62: 221: 36.19
+	Hs
		471579 CO4A2_HUMAN (1-294): 1.63e-27: 123: 28.23		MMP9_HUMAN (23-231): 1.53e-62: 221: 36.19
+	Hs
		391119 CO4A2_HUMAN (1-294): 1.63e-27: 123: 28.23		HEMO_HUMAN (295-532): 4.81e-32: 131: 15.97