HitPredict

Interactor 1: CO1A2 (P08123)
Collagen alpha-2(I) chain (Alpha-2 type I collagen)
Gene: COL1A2

Interactor 2: MMP3 (P08254)
Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1)
Gene: MMP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19010413
Identification Methods	protease assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0071230 - cellular response to amino acid stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1366 Hs			1 477
+	Hs
		399260 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP1_HUMAN (14-477): 0: 615: 53.55
+	Hs
		465939 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP8_HUMAN (12-477): 0: 599: 49.79
+	Hs
		465954 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP16_HUMAN (6-477): 0: 573: 35.37
+	Hs
		465951 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP14_HUMAN (34-477): 0: 558: 38.21
+	Hs
		465953 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP15_HUMAN (34-477): 0: 544: 34.77
+	Hs
		465926 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP2_HUMAN (4-204): 1.26e-84: 275: 47.34
+	Hs
		465931 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP9_HUMAN (13-204): 1.14e-70: 239: 45.77
+	Hs
		384090 CO1A1_HUMAN (14-1018): 1.23e-93: 334: 43.06		MMP2_HUMAN (4-204): 1.26e-84: 275: 47.34
+	Hs
		469662 CO5A1_HUMAN (11-863): 9.04e-61: 232: 42.22		MMP2_HUMAN (4-204): 1.26e-84: 275: 47.34
+	Hs
		575778 CO5A1_HUMAN (11-863): 9.04e-61: 232: 42.22		MMP9_HUMAN (13-204): 1.14e-70: 239: 45.77
+	Hs
		384297 CO4A1_HUMAN (520-1182): 1.05e-43: 176: 33.20		MMP2_HUMAN (4-204): 1.26e-84: 275: 47.34
+	Hs
		384231 CO2A1_HUMAN (713-1173): 8.99e-38: 157: 33.39		MMP2_HUMAN (4-204): 1.26e-84: 275: 47.34
+	Hs
		384300 CO4A1_HUMAN (520-1182): 1.05e-43: 176: 33.20		MMP9_HUMAN (13-204): 1.14e-70: 239: 45.77
+	Hs
		469690 COMA1_HUMAN (6-539): 1.12e-30: 134: 35.52		MMP2_HUMAN (4-204): 1.26e-84: 275: 47.34
+	Hs
		469654 CO4A2_HUMAN (1-294): 1.63e-27: 123: 28.23		MMP2_HUMAN (4-204): 1.26e-84: 275: 47.34
+	Hs
		384239 CO2A1_HUMAN (713-1173): 8.99e-38: 157: 33.39		MMP9_HUMAN (13-204): 1.14e-70: 239: 45.77
+	Hs
		469674 COGA1_HUMAN (3-638): 1.12e-26: 121: 33.55		MMP2_HUMAN (4-204): 1.26e-84: 275: 47.34
+	Hs
		469677 CO4A6_HUMAN (1-291): 9.11e-27: 121: 30.51		MMP2_HUMAN (4-204): 1.26e-84: 275: 47.34
+	Hs
		471579 CO4A2_HUMAN (1-294): 1.63e-27: 123: 28.23		MMP9_HUMAN (13-204): 1.14e-70: 239: 45.77
+	Hs
		391119 CO4A2_HUMAN (1-294): 1.63e-27: 123: 28.23		HEMO_HUMAN (280-477): 3.31e-16: 82.7: 18.22