HitPredict

Interactor 1: CO1A2 (P08123)
Collagen alpha-2(I) chain (Alpha-2 type I collagen)
Gene: COL1A2

Interactor 2: MMP15 (P51511)
Matrix metalloproteinase-15 (MMP-15) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP-2)
Gene: MMP15

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19010413
Identification Methods	protease assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1366 Hs			1 669
+	Hs
		465954 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP16_HUMAN (32-669): 0: 758: 52.35
+	Hs
		465951 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP14_HUMAN (37-669): 0: 665: 51.34
+	Hs
		465927 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP3_HUMAN (30-559): 0: 560: 33.95
+	Hs
		399260 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP1_HUMAN (46-562): 0: 547: 33.14
+	Hs
		465939 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP8_HUMAN (44-560): 0: 538: 33.97
+	Hs
		465926 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP2_HUMAN (25-244): 2.02e-80: 270: 33.48
+	Hs
		465931 CO1A2_HUMAN (1-1366): 0: 739: 100.00		MMP9_HUMAN (48-244): 1.16e-61: 220: 37.06
+	Hs
		384090 CO1A1_HUMAN (14-1018): 1.23e-93: 334: 43.06		MMP2_HUMAN (25-244): 2.02e-80: 270: 33.48
+	Hs
		469662 CO5A1_HUMAN (11-863): 9.04e-61: 232: 42.22		MMP2_HUMAN (25-244): 2.02e-80: 270: 33.48
+	Hs
		575778 CO5A1_HUMAN (11-863): 9.04e-61: 232: 42.22		MMP9_HUMAN (48-244): 1.16e-61: 220: 37.06
+	Hs
		384297 CO4A1_HUMAN (520-1182): 1.05e-43: 176: 33.20		MMP2_HUMAN (25-244): 2.02e-80: 270: 33.48
+	Hs
		384231 CO2A1_HUMAN (713-1173): 8.99e-38: 157: 33.39		MMP2_HUMAN (25-244): 2.02e-80: 270: 33.48
+	Hs
		469690 COMA1_HUMAN (6-539): 1.12e-30: 134: 35.52		MMP2_HUMAN (25-244): 2.02e-80: 270: 33.48
+	Hs
		384300 CO4A1_HUMAN (520-1182): 1.05e-43: 176: 33.20		MMP9_HUMAN (48-244): 1.16e-61: 220: 37.06
+	Hs
		469654 CO4A2_HUMAN (1-294): 1.63e-27: 123: 28.23		MMP2_HUMAN (25-244): 2.02e-80: 270: 33.48
+	Hs
		469674 COGA1_HUMAN (3-638): 1.12e-26: 121: 33.55		MMP2_HUMAN (25-244): 2.02e-80: 270: 33.48
+	Hs
		469677 CO4A6_HUMAN (1-291): 9.11e-27: 121: 30.51		MMP2_HUMAN (25-244): 2.02e-80: 270: 33.48
+	Hs
		384239 CO2A1_HUMAN (713-1173): 8.99e-38: 157: 33.39		MMP9_HUMAN (48-244): 1.16e-61: 220: 37.06
+	Hs
		471579 CO4A2_HUMAN (1-294): 1.63e-27: 123: 28.23		MMP9_HUMAN (48-244): 1.16e-61: 220: 37.06
+	Hs
		391119 CO4A2_HUMAN (1-294): 1.63e-27: 123: 28.23		HEMO_HUMAN (306-559): 6.71e-21: 98.3: 17.03