HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: CEA21 (Q3KPI0)
Cell adhesion molecule CEACAM21 (Carcinoembryonic antigen-related cell adhesion molecule 21) (CEA cell adhesion molecule 21)
Gene: CEACAM21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.80	0.770

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Sema~V-set, TIG~V-set
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1390 Hs			1 293
+	Hs
		472116 MET_HUMAN (1-1390): 0: 1275: 100.00		LRIG1_HUMAN (12-289): 1.23e-45: 166: 15.14
+	Mm
		591103 MET_MOUSE (1-1378): 0: 1242: 89.70		VGFR2_MOUSE (40-240): 6.64e-25: 106: 18.10
+	Hs
		1049179 RON_HUMAN (23-1390): 0: 931: 32.93		TITIN_HUMAN (152-259): 8.53e-09: 58.7: 16.22
+	Hs
		710633 EPHA3_HUMAN (584-1377): 1.43e-176: 553: 18.30		CEA21_HUMAN (1-293): 1.94e-71: 223: 100.00
+	Hs
		932081 EPHA4_HUMAN (555-1389): 5.38e-174: 546: 17.20		CEA21_HUMAN (1-293): 1.94e-71: 223: 100.00
+	Hs
		773347 TIE1_HUMAN (519-1343): 2.99e-158: 509: 20.00		PSG5_HUMAN (2-242): 9.92e-25: 103: 15.73
+	Hs
		731832 EPHB4_HUMAN (736-1342): 4.54e-129: 426: 21.72		CEAM8_HUMAN (12-260): 1.23e-19: 89.1: 14.62
+	Hs
		731828 PLXA3_HUMAN (381-1038): 4.99e-111: 389: 17.62		CEAM8_HUMAN (12-260): 1.23e-19: 89.1: 14.62
+	Hs
		761235 RYK_HUMAN (1078-1334): 2.55e-59: 218: 39.47		CEA21_HUMAN (1-293): 1.94e-71: 223: 100.00
+	Dm
		355880 O96681_DROME (459-1022): 2e-80: 295: 20.87		PTK7_DROME (80-286): 4.77e-19: 89: 21.83
+	Hs
		1145766 ERBB4_HUMAN (1082-1338): 4.99e-52: 203: 42.75		LRIG1_HUMAN (12-289): 1.23e-45: 166: 15.14
+	Hs
		761243 RYK_HUMAN (1078-1334): 2.55e-59: 218: 39.47		CD276_HUMAN (14-254): 1.34e-18: 87.5: 19.01
+	Dm
		1174395 ROR1_DROME (1054-1337): 4.71e-56: 209: 39.18		PTK7_DROME (80-286): 4.77e-19: 89: 21.83
+	Hs
		1145744 ERBB4_HUMAN (1082-1338): 4.99e-52: 203: 42.75		LRIG3_HUMAN (143-281): 3.4e-14: 74.8: 18.42
+	Dm
		1071103 Q0KIF1_DROME (438-555): 3.9e-27: 122: 26.45		PTK7_DROME (80-286): 4.77e-19: 89: 21.83