Protein: K2C78
Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40)

Gene: K2C78, KRT78
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q8N1N4

Gene Ontology (top 5):
GO:0005615 - extracellular space
GO:0005829 - cytosol
GO:0030280 - structural constituent of skin epidermis
GO:0031424 - keratinization
GO:0045095 - keratin filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1127661

KT33B
Keratin, type I cuticular Ha3-II

2

20

High-throughput

0.794

High

1323678

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.794

High

300421

KRT34
Keratin, type I cuticular Ha4

2

20

High-throughput

0.783

High

300589

KRT36
Keratin, type I cuticular Ha6

2

20

High-throughput

0.783

High

385139

K1C14
Keratin, type I cytoskeletal 14

2

20

High-throughput

0.783

High

475632

K1C19
Keratin, type I cytoskeletal 19

2

20

High-throughput

0.783

High

476356

K1C16
Keratin, type I cytoskeletal 16

2

20

High-throughput

0.783

High

618071

K1C15
Keratin, type I cytoskeletal 15

2

20

High-throughput

0.783

High

1146038

K1H1
Keratin, type I cuticular Ha1

2

20

High-throughput

0.783

High

1230332

K1C39
Keratin, type I cytoskeletal 39

2

20

High-throughput

0.783

High

1277574

K1C27
Keratin, type I cytoskeletal 27

2

20

High-throughput

0.783

High

1277674

K1C25
Keratin, type I cytoskeletal 25

2

20

High-throughput

0.783

High

1157230

AINX
Alpha-internexin

1

20

High-throughput

0.691

High

300670

KRT37
Keratin, type I cuticular Ha7

1

20

High-throughput

0.621

High

300793

KRT38
Keratin, type I cuticular Ha8

1

20

High-throughput

0.621

High

566291

K1C13
Keratin, type I cytoskeletal 13

1

20

High-throughput

0.621

High

1127794

K1H2
Keratin, type I cuticular Ha2

1

20

High-throughput

0.621

High

1178741

K1C24
Keratin, type I cytoskeletal 24

1

20

High-throughput

0.621

High

1230130

K1C40
Keratin, type I cytoskeletal 40

1

20

High-throughput

0.621

High

1277663

K1C26
Keratin, type I cytoskeletal 26

1

20

High-throughput

0.621

High

1047447

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.618

High

537501

HSP7C
Heat shock cognate 71 kDa protein

2

3

High-throughput

0.611

High

1323694

CN119
Uncharacterized protein C14orf119

2

1

High-throughput

0.606

High

1323684

TRI54
Tripartite motif-containing protein 54

2

20

High-throughput

0.553

High

164012

NDC80
Kinetochore protein NDC80 homolog

1

20

High-throughput

0.536

High

322425

HAUS5
HAUS augmin-like complex subunit 5

1

1

High-throughput

0.536

High

904334

BRCA2
Breast cancer type 2 susceptibility protein

1

1

High-throughput

0.536

High

945820

EPIPL
Epiplakin

1

20

High-throughput

0.536

High

1049546

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

1086790

BPTF
Nucleosome-remodeling factor subunit BPTF

1

4

High-throughput

0.536

High

1112912

CUL2
Cullin-2

1

20

High-throughput

0.536

High

1113668

CUL3
Cullin-3

1

20

High-throughput

0.536

High

1134641

NUMA1
Nuclear mitotic apparatus protein 1

1

10

High-throughput

0.536

High

1143189

PLEC
Plectin

1

20

High-throughput

0.536

High

1323680

CSN5
COP9 signalosome complex subunit 5

1

17

High-throughput

0.536

High

1312348

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

4

High-throughput

0.515

High

977754

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.513

High

1149329

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.513

High

1323676

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

High-throughput

0.513

High

1323689

DSN1
Kinetochore-associated protein DSN1 homolog

1

0

High-throughput

0.513

High

1006540

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.501

High

1323697

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

10

Small-scale

0.501

High

1068848

IFFO1
Non-homologous end joining factor IFFO1

1

20

High-throughput

0.489

High

1136467

FL2D
Pre-mRNA-splicing regulator WTAP

1

7

High-throughput

0.489

High

1178136

QSER1
Glutamine and serine-rich protein 1

1

2

High-throughput

0.489

High

1253901

FA83H
Protein FAM83H

1

6

High-throughput

0.489

High

1323690

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

15

High-throughput

0.489

High

136934

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.479

High

1140107

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

16

High-throughput

0.479

High

141569

DDX3X
ATP-dependent RNA helicase DDX3X

1

7

Small-scale

0.479

High

302580

RNF8
E3 ubiquitin-protein ligase RNF8

1

16

High-throughput

0.479

High

320722

UBXN7
UBX domain-containing protein 7

1

5

High-throughput

0.479

High

346062

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

349156

LATS1
Serine/threonine-protein kinase LATS1

1

8

High-throughput

0.479

High

390099

ALBU
Albumin

1

4

High-throughput

0.479

High

414193

P53
Cellular tumor antigen p53

1

9

Small-scale

0.479

High

485266

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

8

High-throughput

0.479

High

564044

CFTR
Cystic fibrosis transmembrane conductance regulator

1

18

High-throughput

0.479

High

855683

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

904923

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

907496

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

10

High-throughput

0.479

High

970767

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

10

High-throughput

0.479

High

990485

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

1246880

RICTR
Rapamycin-insensitive companion of mTOR

1

6

High-throughput

0.479

High

1323681

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

8

Small-scale

0.479

High

1323682

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

Small-scale

0.479

High

1323683

ACE2
Angiotensin-converting enzyme 2

1

7

High-throughput

0.479

High

1323687

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.479

High

1323688

RN208
RING finger protein 208

1

20

Small-scale

0.479

High

1323691

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

11

High-throughput

0.479

High

1323692

ANLN
Anillin

1

12

High-throughput

0.479

High

1323693

RNF12
E3 ubiquitin-protein ligase RLIM

1

18

High-throughput

0.479

High

1323696

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

1323698

MRCKB
Serine/threonine-protein kinase MRCK beta

1

3

High-throughput

0.479

High

396491

ESR1
Estrogen receptor

1

16

High-throughput

0.445

High

952241

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

1023830

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

7

High-throughput

0.445

High

1063810

LG3BP
Galectin-3-binding protein

1

9

High-throughput

0.445

High

1209380

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

1310996

SULF2
Extracellular sulfatase Sulf-2

1

10

High-throughput

0.445

High

1323685

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

20

High-throughput

0.445

High

294002

CD123
Translation initiation factor eIF2 assembly protein

1

9

High-throughput

0.437

High

372557

MYC
Myc proto-oncogene protein

1

14

High-throughput

0.437

High

406382

MYCN
N-myc proto-oncogene protein

1

14

High-throughput

0.437

High

606912

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.437

High

1088444

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.437

High

1118093

DX39B
Spliceosome RNA helicase DDX39B

1

20

High-throughput

0.437

High

1132824

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.437

High

1250168

LRC31
Leucine-rich repeat-containing protein 31

1

10

High-throughput

0.437

High

1254609

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1294205

GOLI
E3 ubiquitin-protein ligase RNF130

1

7

High-throughput

0.437

High

1323679

HDAC2
Histone deacetylase 2

1

13

High-throughput

0.437

High

1323686

DDX24
ATP-dependent RNA helicase DDX24

1

20

High-throughput

0.437

High

1081

SIM26
Small integral membrane protein 26

1

7

High-throughput

0.407

High

653432

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.407

High

1119203

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.407

High

1323674

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.407

High

1323675

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.407

High

1323677

ESR2
Estrogen receptor beta

1

16

High-throughput

0.407

High

1323695

Q9NZ47
HCG1811444

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025