HitPredict

Interactor 1: UBA1 (P22515)
Ubiquitin-activating enzyme E1 1 (EC 6.2.1.45)
Gene: UBA1

Interactor 2: UBC12 (P52491)
NEDD8-conjugating enzyme UBC12 (EC 2.3.2.34) (RUB1-conjugating enzyme) (Ubiquitin carrier protein 12)
Gene: UBC12

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21940857
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1024 Sc			1 188
+	Hs
		647626 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2E2_HUMAN (5-177): 1.47e-77: 232: 27.75
+	Hs
		647533 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2D2_HUMAN (28-177): 3.69e-78: 231: 28.67
+	Hs
		647684 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2D4_HUMAN (28-177): 4.8e-78: 231: 29.33
+	Hs
		647506 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2D1_HUMAN (28-177): 1.36e-77: 230: 29.33
+	Hs
		647521 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2D3_HUMAN (28-177): 1.22e-76: 227: 28.67
+	Hs
		647619 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2E3_HUMAN (10-177): 1.36e-75: 227: 26.79
+	Hs
		647508 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2E1_HUMAN (5-177): 3.34e-74: 223: 27.01
+	Hs
		647522 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UBC12_HUMAN (1-183): 2.85e-70: 212: 41.62
+	Hs
		647502 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UBE2A_HUMAN (25-175): 5.37e-69: 208: 33.78
+	Hs
		647537 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UBE2B_HUMAN (25-175): 6.73e-68: 205: 35.10
+	Sc
		585681 UBA1_YEAST (1-1024): 0: 1092: 100.00		UBC4_YEAST (27-177): 3.48e-76: 226: 27.82
+	Sp
		314596 UBA1_SCHPO (1-1024): 0: 1045: 58.19		UBC4_SCHPO (28-177): 7.65e-76: 225: 30.00
+	Hs
		647524 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UBE2N_HUMAN (66-169): 5.72e-19: 80.9: 37.50
+	Hs
		48351 UBA6_HUMAN (2-1024): 0: 974: 40.71		UB2D2_HUMAN (28-177): 3.69e-78: 231: 28.67
+	Hs
		48347 UBA6_HUMAN (2-1024): 0: 974: 40.71		UB2D1_HUMAN (28-177): 1.36e-77: 230: 29.33
+	Hs
		48349 UBA6_HUMAN (2-1024): 0: 974: 40.71		UB2D3_HUMAN (28-177): 1.22e-76: 227: 28.67
+	Sc
		438521 UBA1_YEAST (1-1024): 0: 1092: 100.00		UBC2_YEAST (26-172): 2.94e-21: 87.4: 34.90
+	Hs
		833587 UBA7_HUMAN (5-1024): 0: 913: 37.09		UB2E1_HUMAN (5-177): 3.34e-74: 223: 27.01
+	Sp
		314595 UBA1_SCHPO (1-1024): 0: 1045: 58.19		UBC2_SCHPO (26-172): 6.92e-20: 83.2: 33.33
+	Sp
		150903 UBA1_SCHPO (1-1024): 0: 1045: 58.19		UBC13_SCHPO (70-163): 1.7e-19: 82: 40.43