HitPredict

Interactor 1: SIN3 (P22579)
Transcriptional regulatory protein SIN3
Gene: SIN3

Interactor 2: RPD3 (P32561)
Histone deacetylase RPD3 (EC 3.5.1.98) (Transcriptional regulatory protein RPD3)
Gene: RPD3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 9150136, 9234741, 9512514, 11805826, 23878396, 11156977, 16429126, 16275642, 16286008, 16314178, 16286007, 19806189, 37968396, 36888706, 17101441, 22543816, 15141165, 11024051, 16554755, 26747610 and 3 others

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Identification Methods coimmunoprecipitation, affinity chromatography technology, two hybrid, tandem affinity purification, pull down, biochemical, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Hist_deacetyl~Sin3_corepress, Hist_deacetyl~Sin3a_C
Common GO terms GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
and 15 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 1536
Sc

1 433
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+ Sc
+ Sp
+ Ce
+ Ce
+ Hs
+ Mm
+ Dm
+ Hs
+ Mm
+ Hs
+ Mm
+ Sp
+ Hs
+ At
+ At
+ Hs
+ Dm
+ Mm

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Last updated: 11Aug2025